{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:16:16Z","timestamp":1789020976529,"version":"build-2803163510"},"posted":{"date-parts":[[2024,2,13]]},"group-title":"Neurology","reference-count":93,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,2,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Mild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer\u2019s Disease Neuroimaging Initiative participants with normal cognition or mild cognitive impairment, MBI status was determined alongside corresponding p-tau and A\n                  <jats:italic>\u03b2<\/jats:italic>\n                  . Two meta-regions of interest were generated to represent Braak I and III neuropathological stages. Multivariable linear regression modelled the association between MBI as independent variable and tau tracer uptake as dependent variable. Among A\n                  <jats:italic>\u03b2<\/jats:italic>\n                  positive individuals, MBI was associated with tau uptake in Braak I (\n                  <jats:italic>\u03b2<\/jats:italic>\n                  =0.45(0.15),\n                  <jats:italic>p&lt;.<\/jats:italic>\n                  01) and Braak III (\n                  <jats:italic>\u03b2<\/jats:italic>\n                  =0.24(0.07),\n                  <jats:italic>p&lt;.<\/jats:italic>\n                  01) regions. In A\n                  <jats:italic>\u03b2<\/jats:italic>\n                  negative individuals, MBI was not associated with tau in the Braak I region (p=.11) with a negative association in Braak III (\n                  <jats:italic>p=.<\/jats:italic>\n                  01). These findings suggest MBI may be a sequela of neurodegeneration, and can be implemented as a cost-effective framework to help improve screening efficiency for AD.\n                <\/jats:p>","DOI":"10.1101\/2024.02.11.24302665","type":"posted-content","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T13:50:18Z","timestamp":1707832218000},"source":"Crossref","is-referenced-by-count":1,"title":["Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive 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