{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:44:30Z","timestamp":1784763870986,"version":"3.55.0"},"posted":{"date-parts":[[2024,2,16]]},"group-title":"Microbiology","reference-count":68,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Sporotrichosis, the cutaneous mycosis most commonly reported in Latin America, is caused by the\n                  <jats:italic>Sporothrix<\/jats:italic>\n                  clinical clade species, including\n                  <jats:italic>Sporothrix brasiliensis<\/jats:italic>\n                  and\n                  <jats:italic>Sporothrix schenckii sensu stricto<\/jats:italic>\n                  . In Brazil,\n                  <jats:italic>S. brasiliensis<\/jats:italic>\n                  represents a vital health threat to humans and domestic animals due to its zoonotic transmission. Itraconazole, terbinafine, and amphotericin B are the most used antifungals for treating sporotrichosis. However, many strains of\n                  <jats:italic>S. brasiliensis<\/jats:italic>\n                  and\n                  <jats:italic>S. schenckii<\/jats:italic>\n                  have shown resistance to these agents, highlighting the importance of finding new therapeutic options. Here, we demonstrate that milteforan, a commercial veterinary product against dog leishmaniasis whose active principle is miltefosine, is a possible therapeutic alternative for the treatment of sporotrichosis, as observed by its fungicidal activity\n                  <jats:italic>in vitro<\/jats:italic>\n                  against different strains of\n                  <jats:italic>S. brasiliensis<\/jats:italic>\n                  and\n                  <jats:italic>S. schenckii<\/jats:italic>\n                  , and by its antifungal activity when used to treat infected epithelial cells and macrophages. Our results suggest milteforan as a possible alternative to treat feline sporotrichosis.\n                <\/jats:p>","DOI":"10.1101\/2024.02.14.580352","type":"posted-content","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T14:25:40Z","timestamp":1708093540000},"source":"Crossref","is-referenced-by-count":1,"title":["Milteforan, a promising veterinary commercial product against feline sporotrichosis"],"prefix":"10.64898","author":[{"given":"Laura C.","family":"Garc\u00eda Carnero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaila F.","family":"dos Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Alves","family":"de 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