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We found higher PGS for IFN\u03b3, IL-2, and TNF\u03b1 were predictive of higher post-vaccine IFN\u03b3 (p-value = 2e-6), IL-2 (p = 2e-7), and TNF\u03b1 (p = 0.004) levels, respectively. Control of immune responses after vaccination is complex and polygenic in nature. Our results suggest that the PGS-based approach enables better capture of the combined genetic effects that contribute to mumps vaccine-induced immunity, potentially offering a more comprehensive understanding than traditional single-variant GWAS. This approach will likely have broad utility in studying genetic control of immune responses to other vaccines and to infectious diseases.<\/jats:p>","DOI":"10.1101\/2024.02.23.24303277","type":"posted-content","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T13:55:21Z","timestamp":1709042121000},"source":"Crossref","is-referenced-by-count":0,"title":["Polygenic Prediction of Cellular Immune Responses to Mumps Vaccine"],"prefix":"10.64898","author":[{"given":"Brandon J.","family":"Coombes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna G.","family":"Ovsyannikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Schaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel D.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Poland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024022823501224000_2024.02.23.24303277v1.1","unstructured":"Centers for Disease Control and Prevention. 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