{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:42:30Z","timestamp":1768567350493,"version":"3.49.0"},"posted":{"date-parts":[[2024,2,27]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":46,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Lassa fever is a zoonotic disease identified by the World Health Organization (WHO) as having pandemic potential. This study estimates the health-economic burden of Lassa fever throughout West Africa and projects impacts of a series of vaccination campaigns. We also model the emergence of \u201cLassa-X\u201d \u2013 a hypothetical pandemic Lassa virus variant \u2013 and project impacts of achieving 100 Days Mission vaccination targets. Our model predicted 2.7M (95% uncertainty interval: 2.1M-3.4M) Lassa virus infections annually, resulting over ten years in 2.0M (793.8K-3.9M) disability-adjusted life years (DALYs). The most effective vaccination strategy was a population-wide preventive campaign primarily targeting WHO-classified \u201cendemic\u201d districts. Under conservative vaccine efficacy assumptions, this campaign averted $20.1M ($8.2M-$39.0M) in lost DALY value and $128.2M ($67.2M-$231.9M) in societal costs (International dollars 2021). Reactive vaccination in response to local outbreaks averted just one-tenth the health-economic burden of preventive campaigns. In the event of Lassa-X emerging, spreading throughout West Africa and causing approximately 1.2M DALYs within two years, 100 Days Mission vaccination averted 22% of DALYs given a vaccine 70% effective against disease, and 74% of DALYs given a vaccine 70% effective against both infection and disease. These findings suggest how vaccination could alleviate Lassa fever\u2019s burden and assist in pandemic preparedness.<\/jats:p>","DOI":"10.1101\/2024.02.26.24303394","type":"posted-content","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T15:25:36Z","timestamp":1709047536000},"source":"Crossref","is-referenced-by-count":2,"title":["Health and economic impacts of Lassa vaccination campaigns in West Africa"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-4262","authenticated-orcid":false,"given":"David R 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