{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:59:44Z","timestamp":1768510784560,"version":"3.49.0"},"posted":{"date-parts":[[2024,2,26]]},"group-title":"Molecular Biology","reference-count":106,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,2,26]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  <jats:italic>SELENON<\/jats:italic>\n                  -Related Myopathy (\n                  <jats:italic>SELENON<\/jats:italic>\n                  -RM) is a rare congenital myopathy caused by mutations of the\n                  <jats:italic>SELENON<\/jats:italic>\n                  gene characterized by axial muscle weakness and progressive respiratory insufficiency. Muscle histopathology commonly includes multiminicores or a dystrophic pattern but is often non-specific. The\n                  <jats:italic>SELENON<\/jats:italic>\n                  gene encodes selenoprotein N (SelN), a selenocysteine-containing redox enzyme located in the endo\/sarcoplasmic reticulum membrane where it colocalizes with mitochondria-associated membranes. However, the molecular mechanism(s) by which SelN deficiency causes\n                  <jats:italic>SELENON<\/jats:italic>\n                  -RM are undetermined. A hurdle is the lack of cellular and animal models that show assayable phenotypes. Here we report deep-phenotyping of SelN-deficient zebrafish and muscle cells. SelN-deficient zebrafish exhibit changes in embryonic muscle function and swimming activity in larvae. Analysis of single cell RNAseq data in a zebrafish embryo-atlas revealed coexpression between\n                  <jats:italic>selenon<\/jats:italic>\n                  and genes involved in glutathione redox pathway. SelN-deficient zebrafish and mouse myoblasts exhibit changes in glutathione and redox homeostasis, suggesting a direct relationship with SelN function. We report changes in metabolic function abnormalities in SelN-null myotubes when compared to WT. These results suggest that SelN has functional roles during zebrafish early development and myoblast metabolism.\n                <\/jats:p>","DOI":"10.1101\/2024.02.26.581979","type":"posted-content","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T12:29:12Z","timestamp":1709036952000},"source":"Crossref","is-referenced-by-count":1,"title":["Zebrafish and cellular models of\n                  <i>SELENON<\/i>\n                  -Related Myopathy exhibit novel embryonic and metabolic phenotypes"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9468-5757","authenticated-orcid":false,"given":"Pamela","family":"Barraza-Flores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-0106","authenticated-orcid":false,"given":"Behzad","family":"Moghadaszadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biju","family":"Isaac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily C.","family":"Troiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1490-592X","authenticated-orcid":false,"given":"Shira","family":"Rockowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6522-0835","authenticated-orcid":false,"given":"Piotr","family":"Sliz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8818-0568","authenticated-orcid":false,"given":"Alan H.","family":"Beggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024022806551045000_2024.02.26.581979v1.1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21644"},{"key":"2024022806551045000_2024.02.26.581979v1.2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00321.2016"},{"key":"2024022806551045000_2024.02.26.581979v1.3","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02336-z"},{"key":"2024022806551045000_2024.02.26.581979v1.4","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.1.197"},{"key":"2024022806551045000_2024.02.26.581979v1.5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-9-46"},{"key":"2024022806551045000_2024.02.26.581979v1.6","doi-asserted-by":"publisher","DOI":"10.3109\/10715761003709802"},{"key":"2024022806551045000_2024.02.26.581979v1.7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003847117"},{"key":"2024022806551045000_2024.02.26.581979v1.8","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1038\/s41596-023-00840-9","article-title":"Optimizing the Cell Painting assay for image-based profiling","volume":"18","year":"2023","journal-title":"Nat. Protoc"},{"key":"2024022806551045000_2024.02.26.581979v1.9","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20761"},{"key":"2024022806551045000_2024.02.26.581979v1.10","first-page":"119","article-title":"Tail coiling assay in zebrafish (Danio rerio) embryos: Stage of development, promising positive control candidates, and selection of an appropriate organic solvent for screening of developmental neurotoxicity (DNT)","volume":"13","year":"2021","journal-title":"Water (Switzerland"},{"key":"2024022806551045000_2024.02.26.581979v1.11","first-page":"235","article-title":"Late-onset myopathies: clinical features and diagnosis","volume":"39","year":"2020","journal-title":"Acta Myol. myopathies cardiomyopathies Off. J. Mediterr. Soc. Myol"},{"key":"2024022806551045000_2024.02.26.581979v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.10.005"},{"key":"2024022806551045000_2024.02.26.581979v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00075-8"},{"key":"2024022806551045000_2024.02.26.581979v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2019.11.008"},{"key":"2024022806551045000_2024.02.26.581979v1.15","doi-asserted-by":"publisher","DOI":"10.1086\/342719"},{"key":"2024022806551045000_2024.02.26.581979v1.16","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20077"},{"key":"2024022806551045000_2024.02.26.581979v1.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0587-z"},{"key":"2024022806551045000_2024.02.26.581979v1.18","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900140"},{"key":"2024022806551045000_2024.02.26.581979v1.19","doi-asserted-by":"crossref","first-page":"106101","DOI":"10.1016\/j.biocel.2021.106101","article-title":"It takes two to tango: The essential role of ER-mitochondrial contact sites in mitochondrial dynamics","volume":"141","year":"2021","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"2024022806551045000_2024.02.26.581979v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2013.06.001"},{"key":"2024022806551045000_2024.02.26.581979v1.21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806015105"},{"key":"2024022806551045000_2024.02.26.581979v1.22","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2013"},{"key":"2024022806551045000_2024.02.26.581979v1.23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-6-1"},{"key":"2024022806551045000_2024.02.26.581979v1.24","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017239"},{"key":"2024022806551045000_2024.02.26.581979v1.25","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20879"},{"key":"2024022806551045000_2024.02.26.581979v1.26","doi-asserted-by":"publisher","DOI":"10.1139\/y92-021"},{"key":"2024022806551045000_2024.02.26.581979v1.27","doi-asserted-by":"crossref","first-page":"83299","DOI":"10.7554\/eLife.83299","article-title":"Glycolytic flux-signaling controls mouse embryo mesoderm development","volume":"11","year":"2022","journal-title":"Elife"},{"key":"2024022806551045000_2024.02.26.581979v1.28","doi-asserted-by":"publisher","DOI":"10.1038\/ng713"},{"key":"2024022806551045000_2024.02.26.581979v1.29","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-212688"},{"key":"2024022806551045000_2024.02.26.581979v1.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.04.027"},{"key":"2024022806551045000_2024.02.26.581979v1.31","first-page":"1","article-title":"Role of mitochondria-associated endoplasmic reticulum membranes in insulin sensitivity, energy metabolism, and contraction of skeletal muscle","volume":"9","year":"2022","journal-title":"Front. Mol. Biosci"},{"key":"2024022806551045000_2024.02.26.581979v1.32","doi-asserted-by":"crossref","unstructured":"Peterson, S. M. and Freeman, J. L . (2009). RNA isolation from embryonic zebrafish and cDNA synthesis for gene expression analysis. J. Vis. Exp. 30,.","DOI":"10.3791\/1470"},{"key":"2024022806551045000_2024.02.26.581979v1.33","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg115"},{"key":"2024022806551045000_2024.02.26.581979v1.34","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg115"},{"key":"2024022806551045000_2024.02.26.581979v1.35","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.redox.2018.10.017","article-title":"A maladaptive ER stress response triggers dysfunction in highly active muscles of mice with SELENON loss","volume":"20","year":"2019","journal-title":"Redox Biol"},{"key":"2024022806551045000_2024.02.26.581979v1.36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023094"},{"key":"2024022806551045000_2024.02.26.581979v1.37","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62047"},{"key":"2024022806551045000_2024.02.26.581979v1.38","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s12098-018-2713-1","article-title":"SEPN1-related Rigid Spine Muscular Dystrophy","volume":"85","year":"2018","journal-title":"Indian J. Pediatr"},{"key":"2024022806551045000_2024.02.26.581979v1.39","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199812)37:4<622::AID-NEU10>3.0.CO;2-S"},{"key":"2024022806551045000_2024.02.26.581979v1.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2007.08.011"},{"key":"2024022806551045000_2024.02.26.581979v1.41","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2010"},{"key":"2024022806551045000_2024.02.26.581979v1.42","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821f467c"},{"key":"2024022806551045000_2024.02.26.581979v1.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2018.05.017"},{"key":"2024022806551045000_2024.02.26.581979v1.44","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1002\/acn3.51218","article-title":"Selenoprotein N-related myopathy: a retrospective natural history study to guide clinical trials","volume":"7","year":"2020","journal-title":"Ann. Clin. Transl. Neurol"},{"key":"2024022806551045000_2024.02.26.581979v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.11.004"},{"key":"2024022806551045000_2024.02.26.581979v1.46","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-133X(03)00054-1"},{"key":"2024022806551045000_2024.02.26.581979v1.47","doi-asserted-by":"crossref","first-page":"101176","DOI":"10.1016\/j.redox.2019.101176","article-title":"SELENON (SEPN1) protects skeletal muscle from saturated fatty acid-induced ER stress and insulin resistance","volume":"24","year":"2019","journal-title":"Redox Biol"},{"key":"2024022806551045000_2024.02.26.581979v1.48","first-page":"e1512","article-title":"The clinical, histologic, and genotypic spectrum of SEPN1-related myopathy: A case series","volume":"95","year":"2020","journal-title":"Neurology"},{"key":"2024022806551045000_2024.02.26.581979v1.49","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4362"},{"key":"2024022806551045000_2024.02.26.581979v1.50","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"2024022806551045000_2024.02.26.581979v1.51","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1212\/NXG.0000000000000140","article-title":"Phenotypes, genotypes, and prevalence of congenital myopathies older than 5 years in Denmark","volume":"3","year":"2017","journal-title":"Neurol. Genet"},{"key":"2024022806551045000_2024.02.26.581979v1.52","doi-asserted-by":"publisher","DOI":"10.1089\/OMI.2011.0118\/ASSET\/IMAGES\/LARGE\/FIGURE1.JPEG"},{"key":"2024022806551045000_2024.02.26.581979v1.53","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020479"},{"key":"2024022806551045000_2024.02.26.581979v1.54","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21644"},{"key":"2024022806551045000_2024.02.26.581979v1.55","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00321.2016"},{"key":"2024022806551045000_2024.02.26.581979v1.56","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02336-z"},{"key":"2024022806551045000_2024.02.26.581979v1.57","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.1.197"},{"key":"2024022806551045000_2024.02.26.581979v1.58","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-9-46"},{"key":"2024022806551045000_2024.02.26.581979v1.59","doi-asserted-by":"publisher","DOI":"10.3109\/10715761003709802"},{"key":"2024022806551045000_2024.02.26.581979v1.60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003847117"},{"key":"2024022806551045000_2024.02.26.581979v1.61","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1038\/s41596-023-00840-9","article-title":"Optimizing the Cell Painting assay for image-based profiling","volume":"18","year":"2023","journal-title":"Nat. Protoc"},{"key":"2024022806551045000_2024.02.26.581979v1.62","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20761"},{"key":"2024022806551045000_2024.02.26.581979v1.63","first-page":"119","article-title":"Tail coiling assay in zebrafish (Danio rerio) embryos: Stage of development, promising positive control candidates, and selection of an appropriate organic solvent for screening of developmental neurotoxicity (DNT)","volume":"13","year":"2021","journal-title":"Water (Switzerland"},{"key":"2024022806551045000_2024.02.26.581979v1.64","first-page":"235","article-title":"Late-onset myopathies: clinical features and diagnosis","volume":"39","year":"2020","journal-title":"Acta Myol. myopathies cardiomyopathies Off. J. Mediterr. Soc. Myol"},{"key":"2024022806551045000_2024.02.26.581979v1.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.10.005"},{"key":"2024022806551045000_2024.02.26.581979v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00075-8"},{"key":"2024022806551045000_2024.02.26.581979v1.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2019.11.008"},{"key":"2024022806551045000_2024.02.26.581979v1.68","doi-asserted-by":"publisher","DOI":"10.1086\/342719"},{"key":"2024022806551045000_2024.02.26.581979v1.69","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20077"},{"key":"2024022806551045000_2024.02.26.581979v1.70","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0587-z"},{"key":"2024022806551045000_2024.02.26.581979v1.71","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900140"},{"key":"2024022806551045000_2024.02.26.581979v1.72","doi-asserted-by":"crossref","first-page":"106101","DOI":"10.1016\/j.biocel.2021.106101","article-title":"It takes two to tango: The essential role of ER-mitochondrial contact sites in mitochondrial dynamics","volume":"141","year":"2021","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"2024022806551045000_2024.02.26.581979v1.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2013.06.001"},{"key":"2024022806551045000_2024.02.26.581979v1.74","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806015105"},{"key":"2024022806551045000_2024.02.26.581979v1.75","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2013"},{"key":"2024022806551045000_2024.02.26.581979v1.76","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-6-1"},{"key":"2024022806551045000_2024.02.26.581979v1.77","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017239"},{"key":"2024022806551045000_2024.02.26.581979v1.78","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20879"},{"key":"2024022806551045000_2024.02.26.581979v1.79","doi-asserted-by":"publisher","DOI":"10.1139\/y92-021"},{"key":"2024022806551045000_2024.02.26.581979v1.80","doi-asserted-by":"crossref","first-page":"83299","DOI":"10.7554\/eLife.83299","article-title":"Glycolytic flux-signaling controls mouse embryo mesoderm development","volume":"11","year":"2022","journal-title":"Elife"},{"key":"2024022806551045000_2024.02.26.581979v1.81","doi-asserted-by":"publisher","DOI":"10.1038\/ng713"},{"key":"2024022806551045000_2024.02.26.581979v1.82","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-212688"},{"key":"2024022806551045000_2024.02.26.581979v1.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.04.027"},{"key":"2024022806551045000_2024.02.26.581979v1.84","first-page":"1","article-title":"Role of mitochondria-associated endoplasmic reticulum membranes in insulin sensitivity, energy metabolism, and contraction of skeletal muscle","volume":"9","year":"2022","journal-title":"Front. Mol. Biosci"},{"key":"2024022806551045000_2024.02.26.581979v1.85","doi-asserted-by":"crossref","unstructured":"Peterson, S. M. and Freeman, J. L . (2009). RNA isolation from embryonic zebrafish and cDNA synthesis for gene expression analysis. J. Vis. Exp. 30,.","DOI":"10.3791\/1470"},{"key":"2024022806551045000_2024.02.26.581979v1.86","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg115"},{"key":"2024022806551045000_2024.02.26.581979v1.87","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg115"},{"key":"2024022806551045000_2024.02.26.581979v1.88","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.redox.2018.10.017","article-title":"A maladaptive ER stress response triggers dysfunction in highly active muscles of mice with SELENON loss","volume":"20","year":"2019","journal-title":"Redox Biol"},{"key":"2024022806551045000_2024.02.26.581979v1.89","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023094"},{"key":"2024022806551045000_2024.02.26.581979v1.90","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62047"},{"key":"2024022806551045000_2024.02.26.581979v1.91","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s12098-018-2713-1","article-title":"SEPN1-related Rigid Spine Muscular Dystrophy","volume":"85","year":"2018","journal-title":"Indian J. Pediatr"},{"key":"2024022806551045000_2024.02.26.581979v1.92","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199812)37:4<622::AID-NEU10>3.0.CO;2-S"},{"key":"2024022806551045000_2024.02.26.581979v1.93","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2007.08.011"},{"key":"2024022806551045000_2024.02.26.581979v1.94","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2010"},{"key":"2024022806551045000_2024.02.26.581979v1.95","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821f467c"},{"key":"2024022806551045000_2024.02.26.581979v1.96","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2018.05.017"},{"key":"2024022806551045000_2024.02.26.581979v1.97","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1002\/acn3.51218","article-title":"Selenoprotein N-related myopathy: a retrospective natural history study to guide clinical trials","volume":"7","year":"2020","journal-title":"Ann. Clin. Transl. Neurol"},{"key":"2024022806551045000_2024.02.26.581979v1.98","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.11.004"},{"key":"2024022806551045000_2024.02.26.581979v1.99","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-133X(03)00054-1"},{"key":"2024022806551045000_2024.02.26.581979v1.100","doi-asserted-by":"crossref","first-page":"101176","DOI":"10.1016\/j.redox.2019.101176","article-title":"SELENON (SEPN1) protects skeletal muscle from saturated fatty acid-induced ER stress and insulin resistance","volume":"24","year":"2019","journal-title":"Redox Biol"},{"key":"2024022806551045000_2024.02.26.581979v1.101","first-page":"e1512","article-title":"The clinical, histologic, and genotypic spectrum of SEPN1-related myopathy: A case series","volume":"95","year":"2020","journal-title":"Neurology"},{"key":"2024022806551045000_2024.02.26.581979v1.102","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4362"},{"key":"2024022806551045000_2024.02.26.581979v1.103","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"2024022806551045000_2024.02.26.581979v1.104","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1212\/NXG.0000000000000140","article-title":"Phenotypes, genotypes, and prevalence of congenital myopathies older than 5 years in Denmark","volume":"3","year":"2017","journal-title":"Neurol. Genet"},{"key":"2024022806551045000_2024.02.26.581979v1.105","doi-asserted-by":"publisher","DOI":"10.1089\/OMI.2011.0118\/ASSET\/IMAGES\/LARGE\/FIGURE1.JPEG"},{"key":"2024022806551045000_2024.02.26.581979v1.106","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020479"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2024.02.26.581979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:00:26Z","timestamp":1768456826000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2024.02.26.581979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":106,"URL":"https:\/\/doi.org\/10.1101\/2024.02.26.581979","relation":{},"subject":[],"published":{"date-parts":[[2024,2,26]]},"subtype":"preprint"}}