{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:18:28Z","timestamp":1779272308606,"version":"3.51.4"},"posted":{"date-parts":[[2024,2,27]]},"group-title":"Microbiology","reference-count":63,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFc\u03b3Rs) that counteract antibody-mediated activation\n                  <jats:italic>in vitro<\/jats:italic>\n                  , but their role in infection and pathogenesis is unknown. To examine the\n                  <jats:italic>in vivo<\/jats:italic>\n                  function of vFc\u03b3Rs in animal hosts closely related to humans, we identified and characterized vFc\u03b3Rs encoded by rhesus CMV (RhCMV). We demonstrate that Rh05, Rh152\/151 and Rh173 represent the complete set of RhCMV vFc\u03b3Rs, each displaying functional similarities to their respective HCMV orthologs with respect to antagonizing host Fc\u03b3R activation\n                  <jats:italic>in vitro<\/jats:italic>\n                  . When RhCMV-na\u00efve rhesus macaques were infected with vFc\u03b3R-deleted RhCMV, peak plasma viremia levels and anti-RhCMV antibody responses were comparable to wildtype infections. However, the duration of plasma viremia was significantly shortened in immunocompetent, but not in CD4+ T cell-depleted animals. Since vFc\u03b3Rs were not required for superinfection, we conclude that vFc\u03b3Rs delay control by virus-specific adaptive immune responses, particularly antibodies, during primary infection.\n                <\/jats:p>","DOI":"10.1101\/2024.02.27.582371","type":"posted-content","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:25:21Z","timestamp":1709079921000},"source":"Crossref","is-referenced-by-count":3,"title":["Rhesus Cytomegalovirus-encoded Fc\u03b3-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity"],"prefix":"10.64898","author":[{"given":"Claire 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