{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:01:35Z","timestamp":1768510895794,"version":"3.49.0"},"posted":{"date-parts":[[2024,3,3]]},"group-title":"Microbiology","reference-count":43,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  During major, recent yellow fever (YF) epidemics in Brazil, human cases were attributed only to spillover infections from sylvatic transmission with no evidence of human amplification. Furthermore, the historic absence of YF in Asia, despite abundant peridomestic\n                  <jats:italic>Aedes aegypti<\/jats:italic>\n                  and naive human populations, represents a longstanding enigma. We tested the hypothesis that immunity from dengue (DENV) and Zika (ZIKV) flaviviruses limits YF virus (YFV) viremia and transmission by\n                  <jats:italic>Ae. aegypti<\/jats:italic>\n                  . Prior DENV and ZIKV immunity consistently suppressed YFV viremia in experimentally infected macaques, leading to reductions in\n                  <jats:italic>Ae. aegypti<\/jats:italic>\n                  infection when mosquitoes were fed on infected animals. These results indicate that, in DENV- and ZIKV-endemic regions such as South America and Asia, flavivirus immunity suppresses YFV human amplification potential, reducing the risk of urban outbreaks.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>One-Sentence Summary<\/jats:title>\n                  <jats:p>Immunity from dengue and Zika viruses suppresses yellow fever viremia, preventing infection of mosquitoes and reducing the risk of epidemics.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2024.03.03.583168","type":"posted-content","created":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T22:00:12Z","timestamp":1709503212000},"source":"Crossref","is-referenced-by-count":1,"title":["Yellow Fever Emergence: Role of Heterologous Flavivirus Immunity in Preventing Urban Transmission"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-4071","authenticated-orcid":false,"given":"Divya P.","family":"Shinde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica A.","family":"Plante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionna","family":"Scharton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordyn","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasha R.","family":"Azar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael K.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia","family":"Sacchetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00e2nia P.","family":"Drumond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-3289","authenticated-orcid":false,"given":"Nikos","family":"Vasilakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth S.","family":"Plante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott C.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"issue":"12","key":"2024030515001150000_2024.03.03.583168v1.1","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3390\/v12121349","article-title":"The absence of yellow fever in Asia: History, hypotheses, vector dispersal, possibility of YF in Asia, and other enigmas","volume":"12","year":"2020","journal-title":"Viruses"},{"key":"2024030515001150000_2024.03.03.583168v1.2","doi-asserted-by":"crossref","unstructured":"Monath TP , Barrett ADT . Pathogenesis and pathophysiology of yellow fever. In: Advances in Virus Research [Internet]. Elsevier; 2003 [cited 2022 Feb 3]. p. 343\u201395. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065352703600096","DOI":"10.1016\/S0065-3527(03)60009-6"},{"key":"2024030515001150000_2024.03.03.583168v1.3","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072290"},{"key":"2024030515001150000_2024.03.03.583168v1.4","doi-asserted-by":"crossref","unstructured":"Gershman MD . Addressing a yellow fever vaccine shortage \u2014 United States, 2016\u20132017. MMWR Morb Mortal Wkly Rep [Internet]. 2017 [cited 2022 Apr 14];66. Available from: https:\/\/www.facebook.com\/CDCMMWR","DOI":"10.15585\/mmwr.mm6617e2"},{"key":"2024030515001150000_2024.03.03.583168v1.5","doi-asserted-by":"crossref","unstructured":"Hanley KA , Monath TP , Weaver SC , Rossi SL , Richman RL , Vasilakis N. Fever versus Fever: the role of host and vector susceptibility and interspecific competition in shaping the current and future distributions of the sylvatic cycles of dengue virus and yellow fever virus. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2013 Oct;0:292\u2013311.","DOI":"10.1016\/j.meegid.2013.03.008"},{"key":"2024030515001150000_2024.03.03.583168v1.6","unstructured":"Angola: Epidemic (Yellow Fever) Emergency Plan of Action Preliminary Final Report (MDRAO006) -Angola | ReliefWeb [Internet]. [cited 2022 Jun 30]. 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