{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:22:39Z","timestamp":1771978959880,"version":"3.50.1"},"posted":{"date-parts":[[2024,3,12]]},"group-title":"Evolutionary Biology","reference-count":95,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,3,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  <jats:italic>Aedes aegypti<\/jats:italic>\n                  is the main vector species of yellow fever, dengue, zika and chikungunya. The species is originally from Africa but has experienced a spectacular expansion in its geographic range to a large swath of the world, the demographic effects of which have remained largely understudied. In this report, we examine whole-genome sequences from 6 countries in Africa, North America, and South America to investigate the demographic history of the spread of\n                  <jats:italic>Ae. aegypti<\/jats:italic>\n                  into the Americas its impact on genomic diversity. In the Americas, we observe patterns of strong population structure consistent with relatively low (but probably non-zero) levels of gene flow but occasional long-range dispersal and\/or recolonization events. We also find evidence that the colonization of the Americas has resulted in introduction bottlenecks. However, while each sampling location shows evidence of a past population contraction and subsequent recovery, our results suggest that the bottlenecks in America have led to a reduction in genetic diversity of only \u223c35% relative to African populations, and the American samples have retained high levels of genetic diversity (expected heterozygosity of \u223c0.02 at synonymous sites) and have experienced only a minor reduction in the efficacy of selection. These results evoke the image of an invasive species that has expanded its range with remarkable genetic resilience in the face of strong eradication pressure.\n                <\/jats:p>","DOI":"10.1101\/2024.03.07.584008","type":"posted-content","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T11:50:12Z","timestamp":1710244212000},"source":"Crossref","is-referenced-by-count":1,"title":["Demographic history and the efficacy of selection in the globally invasive mosquito\n                  <i>Aedes aegypti<\/i>"],"prefix":"10.64898","author":[{"given":"Tyler V.","family":"Kent","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-4151","authenticated-orcid":false,"given":"Daniel R.","family":"Schrider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Matute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024031410300945000_2024.03.07.584008v1.1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.094052.109"},{"key":"2024031410300945000_2024.03.07.584008v1.2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13071-017-2096-6","article-title":"Combined target site (kdr) mutations play a primary role in highly pyrethroid resistant phenotypes of Aedes aegypti from Saudi Arabia","volume":"10","year":"2017","journal-title":"Parasit. 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