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This process can extend infections for up to a year; however, infections have been documented to last for over a decade, constituting an unseen reservoir of parasites that undermine eradication and control efforts. How parasites remain immunologically \u201cinvisible\u201d for such lengthy periods is entirely unknown. Here we show that in addition to the accepted paradigm of mono-allelic\n                  <jats:italic>var<\/jats:italic>\n                  gene expression, individual parasites can simultaneously express multiple\n                  <jats:italic>var<\/jats:italic>\n                  genes or enter a state in which little or no\n                  <jats:italic>var<\/jats:italic>\n                  gene expression is detectable. This unappreciated flexibility provides parasites with greater adaptive capacity than previously understood and challenges the dogma of mutually exclusive\n                  <jats:italic>var<\/jats:italic>\n                  gene expression. It also provides an explanation for the antigenically \u201cinvisible\u201d parasites observed in chronic asymptomatic infections.\n                <\/jats:p>","DOI":"10.1101\/2024.03.08.584127","type":"posted-content","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T23:55:11Z","timestamp":1710028511000},"source":"Crossref","is-referenced-by-count":3,"title":["Transcriptional plasticity of virulence genes provides malaria parasites with greater adaptive capacity for avoiding host immunity"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2579-3820","authenticated-orcid":false,"given":"Francesca","family":"Florini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Visone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evi","family":"Hadjimichael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivali","family":"Malpotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"N\u00f6tzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0089-1096","authenticated-orcid":false,"given":"Bj\u00f6rn F.C.","family":"Kafsack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk W.","family":"Deitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024031300451117000_2024.03.08.584127v1.1","unstructured":"WHO, World Malaria Report 2021. 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