{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:55:57Z","timestamp":1768510557815,"version":"3.49.0"},"posted":{"date-parts":[[2024,3,13]]},"group-title":"Developmental Biology","reference-count":97,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  The transitioning of neural stem cells (NSCs) between quiescent and proliferative states is fundamental for brain development and homeostasis. Defects in NSC reactivation are associated with neurodevelopmental disorders.\n                  <jats:italic>Drosophila<\/jats:italic>\n                  quiescent NSCs extend an actin-rich primary protrusion toward the neuropil. However, the function of the actin cytoskeleton during NSC reactivation is unknown. Here, we reveal the fine F-actin structures in the protrusions of quiescent NSCs by expansion and super-resolution microscopy. We show that F-actin polymerization promotes the nuclear translocation of Mrtf, a microcephaly-associated transcription factor, for NSC reactivation and brain development. F-actin polymerization is regulated by a signaling cascade composed of G-protein-coupled receptor (GPCR) Smog, G-protein \u03b1q subunit, Rho1 GTPase, and Diaphanous (Dia)\/Formin during NSC reactivation. Further, astrocytes secrete a Smog ligand Fog to regulate G\u03b1q-Rho1-Dia-mediated NSC reactivation. Together, we establish that the Smog-G\u03b1q-Rho1 signaling axis derived from astrocytes, a NSC niche, regulates Dia-mediated F-actin dynamics in NSC reactivation.\n                <\/jats:p>","DOI":"10.1101\/2024.03.11.584337","type":"posted-content","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T13:40:49Z","timestamp":1710337249000},"source":"Crossref","is-referenced-by-count":1,"title":["Astrocytes control quiescent NSC reactivation via GPCR signaling-mediated F-actin remodeling"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6197-3995","authenticated-orcid":false,"given":"Kun-Yang","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-4352","authenticated-orcid":false,"given":"Mahekta R.","family":"Gujar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-4456","authenticated-orcid":false,"given":"Jiaen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-0938","authenticated-orcid":false,"given":"Wei Yung","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-2770","authenticated-orcid":false,"given":"Jiawen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-7470","authenticated-orcid":false,"given":"Yang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4840-1853","authenticated-orcid":false,"given":"Ye Sing","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5533-0443","authenticated-orcid":false,"given":"Xiang","family":"Teng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-5874","authenticated-orcid":false,"given":"Low Siok Lan","family":"Christine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-3861","authenticated-orcid":false,"given":"Pakorn","family":"Kanchanawong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3230-1062","authenticated-orcid":false,"given":"Yusuke","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4623-1878","authenticated-orcid":false,"given":"Hongyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024031510002618000_2024.03.11.584337v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.01.001"},{"key":"2024031510002618000_2024.03.11.584337v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.10.009"},{"key":"2024031510002618000_2024.03.11.584337v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12551"},{"key":"2024031510002618000_2024.03.11.584337v1.4","doi-asserted-by":"crossref","first-page":"e1008653","DOI":"10.1371\/journal.pgen.1008653","article-title":"Waking 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