{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:59:06Z","timestamp":1768510746369,"version":"3.49.0"},"posted":{"date-parts":[[2024,3,11]]},"group-title":"Microbiology","reference-count":50,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,3,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  <jats:italic>Yersinia pestis<\/jats:italic>\n                  is a gram-negative bacterium and the causative agent for the plague.\n                  <jats:italic>Yersinia spp<\/jats:italic>\n                  . use effector proteins of the type III secretion system (T3SS) to skew the host immune response toward a bacterial advantage during infection. Previous work established that mice which lack the type I IFN receptor (IFNAR), exhibit resistance to pulmonary infection by\n                  <jats:italic>Y. pestis<\/jats:italic>\n                  . In this work, we addressed the efficacy of a single dose administration of neutralizing antibody to IFNAR (MAR1) as a preventive treatment for plague. We show that single dose administration of MAR1 provides protection from mortality due to secondary septicemic plague where it appears to reduce the production of serum TNF\u03b1 during the disease phase. We further demonstrate that the T3SS effector protein YopJ is necessary for MAR1-induced protection, however IFNAR-dependent serum TNF\u03b1 was observed independent of YopJ. We further define tissue-specific anti-bacterial roles of IFNAR that are blocked by YopJ activity indicating that YopJ and IFNAR work in parallel to promote disease. The combined data suggest that therapeutic targeting of IFNAR signaling may reduce the hyper-inflammatory response associated with plague.\n                <\/jats:p>","DOI":"10.1101\/2024.03.11.584497","type":"posted-content","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T23:50:12Z","timestamp":1710201012000},"source":"Crossref","is-referenced-by-count":0,"title":["Protection from plague via single dose administration of antibody to neutralize the type I interferon response"],"prefix":"10.64898","author":[{"given":"KD","family":"Marks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5878-3373","authenticated-orcid":false,"given":"DM","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024031404500843000_2024.03.11.584497v1.1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.1.35"},{"key":"2024031404500843000_2024.03.11.584497v1.2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02504-12"},{"key":"2024031404500843000_2024.03.11.584497v1.3","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2008\/017335-0"},{"key":"2024031404500843000_2024.03.11.584497v1.4","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1093\/cid\/ciz1226","article-title":"Antimicrobial treatment of human plague: A systematic review of the literature on individual cases, 1937-2019","volume":"70","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2024031404500843000_2024.03.11.584497v1.5","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7007e1"},{"key":"2024031404500843000_2024.03.11.584497v1.6","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0191"},{"key":"2024031404500843000_2024.03.11.584497v1.7","doi-asserted-by":"crossref","first-page":"985","DOI":"10.4269\/ajtmh.23-0331","article-title":"Plague gives surprises in the second decade of the twenty-first century","volume":"109","year":"2023","journal-title":"Am J Trop Med Hyg"},{"key":"2024031404500843000_2024.03.11.584497v1.8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000796"},{"key":"2024031404500843000_2024.03.11.584497v1.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709043371004"},{"key":"2024031404500843000_2024.03.11.584497v1.10","doi-asserted-by":"publisher","DOI":"10.3201\/eid0701.010106"},{"key":"2024031404500843000_2024.03.11.584497v1.11","doi-asserted-by":"crossref","unstructured":"Cabanel N , Bouchier C , Rajerison M , Carniel E. 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