{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:50:34Z","timestamp":1768510234306,"version":"3.49.0"},"posted":{"date-parts":[[2024,3,14]]},"group-title":"Neuroscience","reference-count":114,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,3,14]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>\n                  Temporal lobe epilepsy (TLE) causes pervasive and progressive memory impairments, yet the specific circuit changes that drive these deficits remain unclear. To investigate how hippocampal-entorhinal dysfunction contributes to progressive memory deficits in epilepsy, we performed simultaneous\n                  <jats:italic>in vivo<\/jats:italic>\n                  electrophysiology in hippocampus (HPC) and medial entorhinal cortex (MEC) of control and epileptic mice 3 or 8 weeks after pilocarpine-induced status epilepticus (Pilo-SE). We found that HPC synchronization deficits (including reduced theta power, coherence, and altered interneuron spike timing) emerged within 3 weeks of Pilo-SE, aligning with early-onset, relatively subtle memory deficits. In contrast, abnormal synchronization within MEC and between HPC-MEC emerged later, by 8 weeks after Pilo-SE, when spatial memory impairment was more severe. Furthermore, a distinct subpopulation of MEC layer 3 excitatory neurons (active at theta troughs) was specifically impaired in epileptic mice. Together, these findings suggest that hippocampal-entorhinal circuit dysfunction accumulates and shifts as cognitive impairment progresses in TLE.\n                <\/jats:p>","DOI":"10.1101\/2024.03.12.584697","type":"posted-content","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T19:40:11Z","timestamp":1710445211000},"source":"Crossref","is-referenced-by-count":0,"title":["Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9068-3746","authenticated-orcid":false,"given":"Yu","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keziah S.","family":"Diego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7366-8939","authenticated-orcid":false,"given":"Zhe","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-0140","authenticated-orcid":false,"given":"Zo\u00e9 Christenson","family":"Wick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Page-Harley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Page-Harley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Schnipper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia I.","family":"Lamsifer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary T.","family":"Pennington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren M.","family":"Vetere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9332-0342","authenticated-orcid":false,"given":"Paul A.","family":"Philipsberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-9282","authenticated-orcid":false,"given":"Ivan","family":"Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Jurkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christin J.","family":"Rosado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9671-8238","authenticated-orcid":false,"given":"Nadia N.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-0523","authenticated-orcid":false,"given":"Denise J.","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2310-6142","authenticated-orcid":false,"given":"Tristan","family":"Shuman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024031820452184000_2024.03.12.584697v1.1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2013.56.7.275"},{"key":"2024031820452184000_2024.03.12.584697v1.2","unstructured":"Jr, J. E. & Salamon, N . Temporal Lobe Epilepsy. BrainMapping:AnEncyclopedicReference (2015)."},{"key":"2024031820452184000_2024.03.12.584697v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.3"},{"key":"2024031820452184000_2024.03.12.584697v1.4","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20565"},{"key":"2024031820452184000_2024.03.12.584697v1.5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.11.1694"},{"key":"2024031820452184000_2024.03.12.584697v1.6","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.144003"},{"key":"2024031820452184000_2024.03.12.584697v1.7","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1999.1095"},{"key":"2024031820452184000_2024.03.12.584697v1.8","doi-asserted-by":"publisher","DOI":"10.1006\/ebeh.2001.0167"},{"key":"2024031820452184000_2024.03.12.584697v1.9","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.12.1211"},{"key":"2024031820452184000_2024.03.12.584697v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.10.034"},{"key":"2024031820452184000_2024.03.12.584697v1.11","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12100"},{"key":"2024031820452184000_2024.03.12.584697v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18757-2"},{"key":"2024031820452184000_2024.03.12.584697v1.13","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12220"},{"key":"2024031820452184000_2024.03.12.584697v1.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00602.x"},{"key":"2024031820452184000_2024.03.12.584697v1.15","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.779558"},{"key":"2024031820452184000_2024.03.12.584697v1.16","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2045-13.2013"},{"key":"2024031820452184000_2024.03.12.584697v1.17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-04-01016.1985"},{"key":"2024031820452184000_2024.03.12.584697v1.18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3842-09.2009"},{"key":"2024031820452184000_2024.03.12.584697v1.19","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24011"},{"key":"2024031820452184000_2024.03.12.584697v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.03.009"},{"key":"2024031820452184000_2024.03.12.584697v1.21","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/630853"},{"key":"2024031820452184000_2024.03.12.584697v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2017.06.011"},{"key":"2024031820452184000_2024.03.12.584697v1.23","unstructured":"Pierre-Pascal Lenck-Santini, L. M. d. l. P. Neurobiology of the Epilepsies: From Epilepsy: A Comprehensive Textbook. Vol. chapter 12 (2022)."},{"key":"2024031820452184000_2024.03.12.584697v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2020.100810"},{"key":"2024031820452184000_2024.03.12.584697v1.25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001267"},{"key":"2024031820452184000_2024.03.12.584697v1.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.09.004"},{"key":"2024031820452184000_2024.03.12.584697v1.27","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3304"},{"key":"2024031820452184000_2024.03.12.584697v1.28","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23410"},{"key":"2024031820452184000_2024.03.12.584697v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.08.011"},{"key":"2024031820452184000_2024.03.12.584697v1.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2021.107979"},{"key":"2024031820452184000_2024.03.12.584697v1.31","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4636-06.2007"},{"key":"2024031820452184000_2024.03.12.584697v1.32","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229252"},{"key":"2024031820452184000_2024.03.12.584697v1.33","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00193"},{"key":"2024031820452184000_2024.03.12.584697v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.08.037"},{"key":"2024031820452184000_2024.03.12.584697v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/nature08860"},{"key":"2024031820452184000_2024.03.12.584697v1.36","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0559-0"},{"key":"2024031820452184000_2024.03.12.584697v1.37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5024-07.2008"},{"key":"2024031820452184000_2024.03.12.584697v1.38","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-37-11505.2003"},{"key":"2024031820452184000_2024.03.12.584697v1.39","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42148"},{"key":"2024031820452184000_2024.03.12.584697v1.40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4699-08.2009"},{"key":"2024031820452184000_2024.03.12.584697v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146351"},{"key":"2024031820452184000_2024.03.12.584697v1.42","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4297-14.2015"},{"key":"2024031820452184000_2024.03.12.584697v1.43","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310610"},{"key":"2024031820452184000_2024.03.12.584697v1.44","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(93)90083-J"},{"key":"2024031820452184000_2024.03.12.584697v1.45","first-page":"1490","article-title":"MR volumetry of the entorhinal, perirhinal, and temporopolar cortices in drug-refractory temporal lobe epilepsy","volume":"22","year":"2001","journal-title":"AJNR. American journal of neuroradiology"},{"key":"2024031820452184000_2024.03.12.584697v1.46","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.12.1627"},{"key":"2024031820452184000_2024.03.12.584697v1.47","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2015.00027"},{"key":"2024031820452184000_2024.03.12.584697v1.48","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90171-0"},{"key":"2024031820452184000_2024.03.12.584697v1.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.05.001"},{"key":"2024031820452184000_2024.03.12.584697v1.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.03.001"},{"key":"2024031820452184000_2024.03.12.584697v1.51","doi-asserted-by":"publisher","DOI":"10.1038\/nature03721"},{"key":"2024031820452184000_2024.03.12.584697v1.52","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166466"},{"key":"2024031820452184000_2024.03.12.584697v1.53","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125572"},{"key":"2024031820452184000_2024.03.12.584697v1.54","doi-asserted-by":"publisher","DOI":"10.1038\/nature14622"},{"key":"2024031820452184000_2024.03.12.584697v1.55","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021733"},{"key":"2024031820452184000_2024.03.12.584697v1.56","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/381243"},{"key":"2024031820452184000_2024.03.12.584697v1.57","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2976-18.2019"},{"key":"2024031820452184000_2024.03.12.584697v1.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.03.021"},{"key":"2024031820452184000_2024.03.12.584697v1.59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03662.x"},{"key":"2024031820452184000_2024.03.12.584697v1.60","first-page":"681","article-title":"Learning impairment in chronic epileptic rats following pilocarpine-induced status epilepticus","volume":"23","year":"1990","journal-title":"Braz J Med Biol Res"},{"key":"2024031820452184000_2024.03.12.584697v1.61","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2005.38704.x"},{"key":"2024031820452184000_2024.03.12.584697v1.62","doi-asserted-by":"publisher","DOI":"10.1134\/S0012496615040055"},{"key":"2024031820452184000_2024.03.12.584697v1.63","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.06.021"},{"key":"2024031820452184000_2024.03.12.584697v1.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.09.013"},{"key":"2024031820452184000_2024.03.12.584697v1.65","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0831s69"},{"key":"2024031820452184000_2024.03.12.584697v1.66","doi-asserted-by":"publisher","DOI":"10.1101\/lm.41302"},{"key":"2024031820452184000_2024.03.12.584697v1.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.005"},{"key":"2024031820452184000_2024.03.12.584697v1.68","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10622"},{"key":"2024031820452184000_2024.03.12.584697v1.69","doi-asserted-by":"publisher","DOI":"10.1177\/1535759720960464"},{"key":"2024031820452184000_2024.03.12.584697v1.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.11.029"},{"key":"2024031820452184000_2024.03.12.584697v1.71","doi-asserted-by":"publisher","DOI":"10.32607\/20758251-2015-7-2-42-47"},{"key":"2024031820452184000_2024.03.12.584697v1.72","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3137"},{"key":"2024031820452184000_2024.03.12.584697v1.73","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3241"},{"key":"2024031820452184000_2024.03.12.584697v1.74","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15840-6"},{"key":"2024031820452184000_2024.03.12.584697v1.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111232"},{"key":"2024031820452184000_2024.03.12.584697v1.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.11.015"},{"key":"2024031820452184000_2024.03.12.584697v1.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.035"},{"key":"2024031820452184000_2024.03.12.584697v1.78","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan3846"},{"key":"2024031820452184000_2024.03.12.584697v1.79","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4062"},{"key":"2024031820452184000_2024.03.12.584697v1.80","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05378-6"},{"key":"2024031820452184000_2024.03.12.584697v1.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.09.019"},{"key":"2024031820452184000_2024.03.12.584697v1.82","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh170"},{"key":"2024031820452184000_2024.03.12.584697v1.83","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-10-06301.1995"},{"key":"2024031820452184000_2024.03.12.584697v1.84","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00203-X"},{"key":"2024031820452184000_2024.03.12.584697v1.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.01.016"},{"key":"2024031820452184000_2024.03.12.584697v1.86","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318181b8ae"},{"key":"2024031820452184000_2024.03.12.584697v1.87","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.07.097"},{"key":"2024031820452184000_2024.03.12.584697v1.88","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.07.045"},{"key":"2024031820452184000_2024.03.12.584697v1.89","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0064-06.2006"},{"key":"2024031820452184000_2024.03.12.584697v1.90","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3182-06.2007"},{"key":"2024031820452184000_2024.03.12.584697v1.91","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-24-08471.2003"},{"key":"2024031820452184000_2024.03.12.584697v1.92","doi-asserted-by":"publisher","DOI":"10.1177\/15357597221112801"},{"key":"2024031820452184000_2024.03.12.584697v1.93","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69293"},{"key":"2024031820452184000_2024.03.12.584697v1.94","doi-asserted-by":"publisher","DOI":"10.1101\/2023.02.21.529420"},{"key":"2024031820452184000_2024.03.12.584697v1.95","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2020.3030714"},{"key":"2024031820452184000_2024.03.12.584697v1.96","doi-asserted-by":"publisher","DOI":"10.1038\/nature17955"},{"key":"2024031820452184000_2024.03.12.584697v1.97","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137461"},{"key":"2024031820452184000_2024.03.12.584697v1.98","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.042"},{"key":"2024031820452184000_2024.03.12.584697v1.99","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.051"},{"key":"2024031820452184000_2024.03.12.584697v1.100","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-01-00388.1998"},{"key":"2024031820452184000_2024.03.12.584697v1.101","doi-asserted-by":"publisher","DOI":"10.1038\/nature08010"},{"key":"2024031820452184000_2024.03.12.584697v1.102","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00953.2003"},{"key":"2024031820452184000_2024.03.12.584697v1.103","doi-asserted-by":"publisher","DOI":"10.1038\/nature06957"},{"key":"2024031820452184000_2024.03.12.584697v1.104","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00464.2015"},{"key":"2024031820452184000_2024.03.12.584697v1.105","unstructured":"George Paxinos, K. B. J. F. Paxinos and Franklin\u2019s the Mouse Brain in Stereotaxic Coordinates. (2019)."},{"key":"2024031820452184000_2024.03.12.584697v1.106","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.06.020"},{"key":"2024031820452184000_2024.03.12.584697v1.107","doi-asserted-by":"crossref","unstructured":"Partha P Mitra, H. B. Observed Brain Dynamics. Vol. Chapter 12 (2008).","DOI":"10.1093\/acprof:oso\/9780195178081.001.0001"},{"key":"2024031820452184000_2024.03.12.584697v1.108","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(69)90092-3"},{"key":"2024031820452184000_2024.03.12.584697v1.109","doi-asserted-by":"crossref","unstructured":"WL McFarland, H. T. , EK Hedges . Relationship between hippocampal theta activity and running speed in the rat. J Comp Physiol Psychol (1975).","DOI":"10.21236\/ADA005364"},{"key":"2024031820452184000_2024.03.12.584697v1.110","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf4588"},{"key":"2024031820452184000_2024.03.12.584697v1.111","doi-asserted-by":"crossref","unstructured":"Pachitariu, M. , Sridhar, S. , & Stringer, C. Solving the spike sorting problem with Kilosort. bioRxiv (2023).","DOI":"10.1101\/2023.01.07.523036"},{"key":"2024031820452184000_2024.03.12.584697v1.112","doi-asserted-by":"crossref","unstructured":"Girish, V. & Vijayalakshmi, A . Affordable image analysis using NIH Image\/ImageJ. Indian J Cancer 41, 47 (2004).","DOI":"10.4103\/0019-509X.12345"},{"key":"2024031820452184000_2024.03.12.584697v1.113","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"2024031820452184000_2024.03.12.584697v1.114","doi-asserted-by":"crossref","unstructured":"Berens, P . CircStat: A MATLAB Toolbox for Circular Statistics. Journal of Statistical Software (2009).","DOI":"10.18637\/jss.v031.i10"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2024.03.12.584697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:06:43Z","timestamp":1768457203000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2024.03.12.584697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,14]]},"references-count":114,"URL":"https:\/\/doi.org\/10.1101\/2024.03.12.584697","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1016\/j.celrep.2024.115131","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2024,3,14]]},"subtype":"preprint"}}