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We analysed kidney transcriptome patterns in two different strains of mice flown on the International Space Station, C57BL\/6J and BALB\/c. Here we show a link between spaceflight and transcriptome patterns associated with dysregulation of lipid and extracellular matrix metabolism and altered transforming growth factor-beta signalling. A stronger response was seen in C57BL\/6J mice than BALB\/c. Genetic differences in hyaluronan metabolism between strains may confer protection against extracellular matrix remodelling through downregulation of epithelial-mesenchymal transition. We intend for our findings to contribute to development of new countermeasures against kidney disease in astronauts and people here on Earth.<\/jats:p>","DOI":"10.1101\/2024.03.13.584781","type":"posted-content","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T21:45:20Z","timestamp":1710452720000},"source":"Crossref","is-referenced-by-count":2,"title":["Spaceflight causes strain dependent gene expression changes associated with lipid and extracellular matrix dysregulation in the mouse kidney in vivo"],"prefix":"10.64898","author":[{"given":"Rebecca H.","family":"Finch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Vitry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6502-5095","authenticated-orcid":false,"given":"Keith","family":"Siew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-531X","authenticated-orcid":false,"given":"Afshin","family":"Behesti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4558-0400","authenticated-orcid":false,"given":"Gary","family":"Hardiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-2884","authenticated-orcid":false,"given":"Willian A.","family":"da Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024071710151347000_2024.03.13.584781v3.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.050"},{"key":"2024071710151347000_2024.03.13.584781v3.2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103176"},{"key":"2024071710151347000_2024.03.13.584781v3.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.002"},{"key":"2024071710151347000_2024.03.13.584781v3.4","unstructured":"Gray, T. 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