{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:40:00Z","timestamp":1776336000545,"version":"3.51.2"},"posted":{"date-parts":[[2024,4,11]]},"group-title":"Neuroscience","reference-count":52,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Problematic opioid use that emerges in a subset of individuals may be due to pre-existing disruptions in the biobehavioral mechanisms that regulate drug use. The identity of these mechanisms is not known, but emerging evidence suggests that suboptimal decision-making that is observable prior to drug use may contribute to the pathology of addiction and, notably, serve as a powerful phenotype for interrogating biologically based differences in opiate-taking behaviors. The current study investigated the relationship between decision-making phenotypes and opioid-taking behaviors in male and female Long Evans rats. Adaptive decision-making processes were assessed using a probabilistic reversal-learning task and oxycodone- (or vehicle, as a control) taking behaviors assessed for 32 days using a saccharin fading procedure that promoted dynamic intake of oxycodone. Tests of motivation, extinction, and reinstatement were also performed. Computational analyses of decision-making and opioid-taking behaviors revealed that attenuated reward-guided decision-making was associated with greater self-administration of oxycodone and addiction-relevant behaviors. Moreover, pre-existing impairments in reward-guided decision-making observed in female rats was associated with greater oxycodone use and addiction-relevant behaviors when compared to males. These results provide new insights into the biobehavioral mechanisms that regulate opiate-taking behaviors and offer a novel phenotypic approach for interrogating sex differences in addiction susceptibility and opioid use disorders.<\/jats:p>","DOI":"10.1101\/2024.04.09.587443","type":"posted-content","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T23:15:10Z","timestamp":1712877310000},"source":"Crossref","is-referenced-by-count":1,"title":["Sex differences in oxycodone-taking behaviors are linked to disruptions in reward-guided, decision-making functions"],"prefix":"10.64898","author":[{"given":"Kaitlyn","family":"LaRocco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peroushini","family":"Villiamma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara A.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph J.","family":"DiLeone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie M.","family":"Groman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024041306450768000_2024.04.09.587443v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1209"},{"key":"2024041306450768000_2024.04.09.587443v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.01.007"},{"key":"2024041306450768000_2024.04.09.587443v1.3","doi-asserted-by":"crossref","unstructured":"Carrasco-Garrido P , Gallardo-Pino C , Jim\u00e9nez-Trujillo I , Hern\u00e1ndez-Barrera V , Garc\u00eda-G\u00f3mez-Heras S , Lima Florencio L , Palacios-Ce\u00f1a D (2022) Nationwide Population-Based Study About Patterns of Prescription Opioid Use and Misuse Among Young Adults in Spain. 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