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The proximal SLiM mimics an R-SNARE motif to recruit syntaxin (STX) 7 and 12-containing vesicles to the inclusion. The distal SLiM mimics the Sorting Nexin (SNX) 5 and 6 cargo binding site to recruit SNX6-containing vesicles to the inclusion. By simultaneously binding to two distinct vesicle classes, IncE reprograms host cell trafficking to promote the formation of a class of hybrid vesicles at the inclusion that are required for\n                  <jats:italic>C. trachomatis<\/jats:italic>\n                  intracellular development. Our work suggests that Incs may have evolved SLiMs to facilitate rapid evolution in a limited protein space to disrupt host cell processes.\n                <\/jats:p>","DOI":"10.1101\/2024.04.23.590830","type":"posted-content","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T23:20:16Z","timestamp":1714000816000},"source":"Crossref","is-referenced-by-count":2,"title":["The\n                  <i>Chlamydia<\/i>\n                  effector IncE employs two short linear motifs to reprogram host vesicle trafficking"],"prefix":"10.64898","author":[{"given":"Khavong","family":"Pha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Mirrashidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Sherry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuong Joseph","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara M.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherilyn A.","family":"Elwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2168-9711","authenticated-orcid":false,"given":"Joanne N.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024042622101903000_2024.04.23.590830v1.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004883"},{"key":"2024042622101903000_2024.04.23.590830v1.2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057090"},{"key":"2024042622101903000_2024.04.23.590830v1.3","doi-asserted-by":"crossref","unstructured":"Barnes, R.C. , Suchland, R.J. , Wang, S.-P. , Kuo, C.-C. , and Stamm, W.E. 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