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In a preliminary sample of healthy adolescents (n=12, 8-25 years), we investigated relationships between 4D flow MRI-derived blood velocity and blood flow in bilateral anterior, middle, and posterior cerebral arteries and BOLD cerebrovascular reactivity in associated vascular territories. As hypothesized, higher velocities in large arteries are associated with an earlier response to a vasodilatory stimulus (cerebrovascular reactivity delay) in the downstream territory. Higher blood flow through these arteries is associated with a larger BOLD response to a vasodilatory stimulus (cerebrovascular reactivity amplitude) in the associated territory. These trends are consistent in a case study of adult moyamoya disease. In our small adolescent cohort, macrovascular-microvascular relationships for velocity\/delay and flow\/CVR change with age, though underlying mechanisms are unclear. Our work emphasizes the need to better characterize this key stage of human brain development, when cerebrovascular hemodynamics are changing, and standard imaging methods offer limited insight into these processes. We provide important normative data for future comparisons in pathology, where combining macro- and microvascular assessments may better help us prevent, stratify, and treat cerebrovascular disease.<\/jats:p>","DOI":"10.1101\/2024.04.26.590312","type":"posted-content","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T14:20:22Z","timestamp":1714400422000},"source":"Crossref","is-referenced-by-count":0,"title":["Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2239-7902","authenticated-orcid":false,"given":"Kristina M.","family":"Zvolanek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0084-4695","authenticated-orcid":false,"given":"Jackson 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