{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:31:13Z","timestamp":1793413873289,"version":"4.5.0"},"posted":{"date-parts":[[2024,5,18]]},"group-title":"Immunology","reference-count":91,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,5,18]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>\n                  Systemic lupus erythematosus (SLE) is an autoimmune disease preferentially observed in females. X-linked gene expression in XX females is normalized to that of XY males by X-Chromosome Inactivation (XCI). However, B cells from female SLE patients and mouse models of SLE exhibit mislocalization of Xist RNA, a critical regulator of XCI, and aberrant expression of X-linked genes, suggesting that impairment of XCI may contribute to disease. Here, we find that a subset of female mice harboring a conditional deletion of\n                  <jats:italic>Xis<\/jats:italic>\n                  t in B cells (\u201cXist cKO\u201d) spontaneously develop SLE phenotypes, including expanded activated B cell subsets, disease-specific autoantibodies, and glomerulonephritis. Moreover, pristane-induced SLE-like disease is more severe in Xist cKO mice. Activated B cells from Xist cKO mice with SLE phenotypes have increased expression of proinflammatory X-linked genes implicated in SLE. Together, this work indicates that impaired XCI maintenance in B cells directly contributes to the female-bias of SLE.\n                <\/jats:p>","DOI":"10.1101\/2024.05.15.594175","type":"posted-content","created":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T00:50:10Z","timestamp":1716079810000},"source":"Crossref","is-referenced-by-count":16,"title":["<i>Xist<\/i>\n                  Deletion in B Cells Results in Systemic Lupus Erythematosus Phenotypes"],"prefix":"10.64898","author":[{"given":"Claudia D.","family":"Lovell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Jiwrajka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley K.","family":"Amerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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