{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:06:11Z","timestamp":1768568771482,"version":"3.49.0"},"posted":{"date-parts":[[2024,5,28]]},"group-title":"Neurology","reference-count":49,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,5,28]]},"abstract":"<jats:title>STRUCTURED ABSTRACT<\/jats:title>\n                <jats:sec id=\"s21\">\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>The relationship between cerebrovascular disease (CVD) and amyloid-\u03b2 (A\u03b2) in Alzheimer disease (AD) is understudied. We hypothesized that magnetic resonance imaging (MRI)-based CVD biomarkers, including cerebral microbleeds (CMBs), ischemic infarction, and white matter hyperintensities (WMH), would correlate with A\u03b2 positivity on positron emission tomography (A\u03b2-PET).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec id=\"s22\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We cross-sectionally analyzed data from the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI, N=1,352). Logistic regression was used to calculate odds ratios (ORs), with A\u03b2-PET positivity as the standard-of-truth.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec id=\"s23\">\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>\n                    Following adjustment, WMH (OR=1.25) and superficial CMBs (OR=1.45) remained positively associated with A\u03b2-PET positivity (p&lt;.001). Deep CMBs and infarcts exhibited a varied relationship with A\u03b2-PET in cognitive subgroups. The combined diagnostic model, which included CVD biomarkers and other accessible measures, significantly predicted A\u03b2-PET (pseudo-R\n                    <jats:sup>2<\/jats:sup>\n                    =.41).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec id=\"s24\">\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>\n                    The study highlights the translational value of CVD biomarkers in diagnosing AD, and underscores the need for more research on their inclusion in diagnostic criteria.\n                    <jats:bold>ClinicalTrials.gov:<\/jats:bold>\n                    ADNI-2 (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT01231971\">NCT01231971<\/jats:ext-link>\n                    ), ADNI-3 (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT02854033\">NCT02854033<\/jats:ext-link>\n                    )\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2024.05.28.24308056","type":"posted-content","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T01:25:22Z","timestamp":1716945922000},"source":"Crossref","is-referenced-by-count":0,"title":["Utility of cerebrovascular imaging biomarkers to detect cerebral amyloidosis"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-1535","authenticated-orcid":false,"given":"Matthew D.","family":"Howe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan R.","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masood","family":"Manoochehri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary J.","family":"Kunicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheina","family":"Emrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward D.","family":"Huey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen P.","family":"Salloway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwamee","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024053104350968000_2024.05.28.24308056v1.1","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s Association. 2024 Alzheimer\u2019s Disease Facts and Figures. 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