{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:53:28Z","timestamp":1768510408621,"version":"3.49.0"},"posted":{"date-parts":[[2024,6,2]]},"group-title":"Bioengineering","reference-count":47,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  The human aorta undergoes complex morphologic changes that indicate the evolution of disease. Finite element analysis enables the prediction of aortic pathologic states, but the absence of a biomechanical understanding hinders the applicability of this computational tool. We incorporate geometric information from computed tomography angiography (CTA) imaging scans into finite element analysis (FEA) to predict a trajectory of future geometries for four aortic disease patients. Through defining a geometric correspondence between two patient scans separated in time, a patient-specific FEA model can recreate the deformation of the aorta between the two time points, showing pathologic growth drives morphologic heterogeneity. A shape-size geometric feature space plotting the variance of the shape index versus the inverse square root of aortic surface area (\u03b4\ud835\udcae vs.\n                  <jats:inline-formula>\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"596335v1_inline1.gif\"\/>\n                  <\/jats:inline-formula>\n                  ) quantitatively demonstrates the simulated breakdown in aortic shape. An increase in \u03b4\ud835\udcae closely parallels the true geometric progression of aortic disease patients.\n                <\/jats:p>","DOI":"10.1101\/2024.05.28.596335","type":"posted-content","created":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T18:55:20Z","timestamp":1717354520000},"source":"Crossref","is-referenced-by-count":0,"title":["A Patient-Specific Morphoelastic Growth Model of Aortic Dissection Evolution"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-6133","authenticated-orcid":false,"given":"Kameel","family":"Khabaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junsung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Milner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nhung","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2652-9714","authenticated-orcid":false,"given":"Luka","family":"Pocivavsek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024060610100890000_2024.05.28.596335v1.1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X16642318"},{"key":"2024060610100890000_2024.05.28.596335v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2021.11.002"},{"key":"2024060610100890000_2024.05.28.596335v1.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138386.48852.b6"},{"key":"2024060610100890000_2024.05.28.596335v1.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu281"},{"key":"2024060610100890000_2024.05.28.596335v1.5","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3986"},{"key":"2024060610100890000_2024.05.28.596335v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.05.003"},{"key":"2024060610100890000_2024.05.28.596335v1.7","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195510000-00005"},{"key":"2024060610100890000_2024.05.28.596335v1.8","doi-asserted-by":"publisher","DOI":"10.21037\/jovs.2018.06.04"},{"key":"2024060610100890000_2024.05.28.596335v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.008"},{"key":"2024060610100890000_2024.05.28.596335v1.10","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.6819"},{"key":"2024060610100890000_2024.05.28.596335v1.11","doi-asserted-by":"publisher","DOI":"10.1177\/1538574409347392"},{"key":"2024060610100890000_2024.05.28.596335v1.12","doi-asserted-by":"publisher","DOI":"10.1177\/0003319706290741"},{"key":"2024060610100890000_2024.05.28.596335v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejro.2021.100333"},{"key":"2024060610100890000_2024.05.28.596335v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2021.04.029"},{"key":"2024060610100890000_2024.05.28.596335v1.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.09.018"},{"key":"2024060610100890000_2024.05.28.596335v1.16","doi-asserted-by":"publisher","DOI":"10.3390\/jpm10020028"},{"key":"2024060610100890000_2024.05.28.596335v1.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107052"},{"key":"2024060610100890000_2024.05.28.596335v1.18","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-012-0691-4"},{"key":"2024060610100890000_2024.05.28.596335v1.19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1011815"},{"key":"2024060610100890000_2024.05.28.596335v1.20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4245"},{"key":"2024060610100890000_2024.05.28.596335v1.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-022-00699-2"},{"key":"2024060610100890000_2024.05.28.596335v1.22","doi-asserted-by":"publisher","DOI":"10.1136\/medethics-2020-106820"},{"key":"2024060610100890000_2024.05.28.596335v1.23","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-18095-8"},{"key":"2024060610100890000_2024.05.28.596335v1.24","unstructured":"P. Erhart , M. L. Liljeqvist , J. Roy , T. C. Gasser , D. B\u00f6ckler , Does Finite Element Analysis Enable Us to Predict Rupture?"},{"key":"2024060610100890000_2024.05.28.596335v1.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2019.04.041"},{"key":"2024060610100890000_2024.05.28.596335v1.26","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2010.46"},{"key":"2024060610100890000_2024.05.28.596335v1.27","unstructured":"D. Arthur , S. Vassilvitskii , k-means++: the advantages of careful seeding, in: Proceedings of the eighteenth annual ACM-SIAM symposium on Discrete algorithms, SODA \u201807, Society for Industrial and Applied Mathematics, USA, 2007, pp. 1027\u20131035."},{"key":"2024060610100890000_2024.05.28.596335v1.28","doi-asserted-by":"publisher","DOI":"10.1145\/355744.355745"},{"key":"2024060610100890000_2024.05.28.596335v1.29","doi-asserted-by":"crossref","unstructured":"A. Goriely , The Mathematics and Mechanics of Biological Growth, Springer, 2017, google-Books-ID: rgImDwAAQBAJ.","DOI":"10.1007\/978-0-387-87710-5"},{"key":"2024060610100890000_2024.05.28.596335v1.30","doi-asserted-by":"publisher","DOI":"10.1002\/gamm.201510016"},{"key":"2024060610100890000_2024.05.28.596335v1.31","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-006-0062-x"},{"key":"2024060610100890000_2024.05.28.596335v1.32","unstructured":"ABAQUS Theory Manual (6.14), Dassault Syst\u00e8mes, Providence, RI, 2014. URL http:\/\/130.149.89.49:2080\/v6.14\/books\/stm\/default.htm"},{"key":"2024060610100890000_2024.05.28.596335v1.33","doi-asserted-by":"publisher","DOI":"10.1007\/s00033-016-0623-5"},{"key":"2024060610100890000_2024.05.28.596335v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/0262-8856(92)90076-F"},{"key":"2024060610100890000_2024.05.28.596335v1.35","unstructured":"J. J. Koenderink , Solid Shape, The MIT Press, Cambridge, Massachusetts, 1990. URL https:\/\/mitpress.mit.edu\/9780262111393\/solid-shape\/"},{"key":"2024060610100890000_2024.05.28.596335v1.36","doi-asserted-by":"publisher","DOI":"10.1109\/TDPVT.2004.1335277"},{"key":"2024060610100890000_2024.05.28.596335v1.37","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-87710-5"},{"key":"2024060610100890000_2024.05.28.596335v1.38","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-87710-5"},{"key":"2024060610100890000_2024.05.28.596335v1.39","unstructured":"B. Audoly , Y. Pomeau , The Elastic Torus, in: Elasticity and Geometry: From hair curls to the nonlinear response of shells, Oxford University Press, Oxford, New York, 2010, pp. 454\u2013489."},{"key":"2024060610100890000_2024.05.28.596335v1.40","doi-asserted-by":"crossref","unstructured":"A. Libai , J. G. Simmonds Axishells , in: The Nonlinear Theory of Elastic Shells, Cambridge University Press, 1998, pp. 250\u2013265, google-Books-ID: iXE knyRhOAC.","DOI":"10.1017\/CBO9780511574511"},{"key":"2024060610100890000_2024.05.28.596335v1.41","doi-asserted-by":"publisher","DOI":"10.1161\/HCI.0000000000000075"},{"key":"2024060610100890000_2024.05.28.596335v1.42","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.16173"},{"key":"2024060610100890000_2024.05.28.596335v1.43","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2021-018551"},{"key":"2024060610100890000_2024.05.28.596335v1.44","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-020-02461-9"},{"key":"2024060610100890000_2024.05.28.596335v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.02.029"},{"key":"2024060610100890000_2024.05.28.596335v1.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2020.08.096"},{"key":"2024060610100890000_2024.05.28.596335v1.47","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00207-5"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2024.05.28.596335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:30:53Z","timestamp":1768458653000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2024.05.28.596335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,2]]},"references-count":47,"URL":"https:\/\/doi.org\/10.1101\/2024.05.28.596335","relation":{},"subject":[],"published":{"date-parts":[[2024,6,2]]},"subtype":"preprint"}}