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PVN loudness adjustments were \u201csticky\u201d, such that a single bout of 40Hz PVN stimulation sustainably suppressed ACtx sound responsiveness, potentiated feedforward inhibition, and behaviorally desensitized mice to loudness. Sensory sensitivity is a cardinal feature of autism, aging, and peripheral neuropathy, prompting us to ask whether PVN stimulation can persistently desensitize mice with ACtx hyperactivity, PVN hypofunction, and loudness hypersensitivity triggered by cochlear sensorineural damage. We found that a single 16-minute bout of 40Hz PVN stimulation session restored normal loudness perception for one week, showing that perceptual deficits triggered by irreversible peripheral injuries can be reversed through targeted cortical circuit interventions.<\/jats:p>","DOI":"10.1101\/2024.05.30.596691","type":"posted-content","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T23:20:10Z","timestamp":1717111210000},"source":"Crossref","is-referenced-by-count":2,"title":["Cortical determinants of loudness perception and auditory hypersensitivity"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0045-4286","authenticated-orcid":false,"given":"Kameron K","family":"Clayton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-9580","authenticated-orcid":false,"given":"Matthew","family":"McGill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6359-0413","authenticated-orcid":false,"given":"Bshara","family":"Awwad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6115-5159","authenticated-orcid":false,"given":"Kamryn S","family":"Stecyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1222-4396","authenticated-orcid":false,"given":"Caroline","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9918-5716","authenticated-orcid":false,"given":"Desislava","family":"Skerleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya P","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth E","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon G","family":"Kujawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0305-0682","authenticated-orcid":false,"given":"Elliott D","family":"Kozin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5120-2409","authenticated-orcid":false,"given":"Daniel B","family":"Polley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024060105450724000_2024.05.30.596691v1.1","first-page":"1835","volume":"1847","year":"1974","journal-title":"Rate versus level functions for auditory-nerve fibers in cats: tone-burst stimuli"},{"key":"2024060105450724000_2024.05.30.596691v1.2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022111980"},{"key":"2024060105450724000_2024.05.30.596691v1.3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5072-09.2010"},{"key":"2024060105450724000_2024.05.30.596691v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.01.019"},{"key":"2024060105450724000_2024.05.30.596691v1.5","unstructured":"Tobin, M. , Sheth, J. , Wood, K.C. , Michel, E.K. , and Geffen, M.N . 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