{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:35:36Z","timestamp":1793126136713,"version":"4.5.0"},"posted":{"date-parts":[[2024,6,10]]},"group-title":"Neuroscience","reference-count":82,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 Research and Innovation Program","award":["785907 (HBP SGA2, CL, PR, ML & LM)"],"award-info":[{"award-number":["785907 (HBP SGA2, CL, PR, ML & LM)"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Program","award":["945539 (HBP SGA3, CL, PR, ML & LM)"],"award-info":[{"award-number":["945539 (HBP SGA3, CL, PR, ML & LM)"]}]},{"name":"NWO","award":["VI.Veni.222.217 (PP)"],"award-info":[{"award-number":["VI.Veni.222.217 (PP)"]}]},{"name":"NWO","award":["OCENW.KLEIN.178 (CNL)"],"award-info":[{"award-number":["OCENW.KLEIN.178 (CNL)"]}]},{"award":["ERC 101219949 (PP)"],"award-info":[{"award-number":["ERC 101219949 (PP)"]}],"id":[{"id":"https:\/\/ror.org\/00k4n6c32","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,10,22]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>To navigate complex environments, the mammalian visual system prioritizes informative inputs by comparing incoming sensory signals with learned contextual information. While this process is often conceptualized as a difference computation, cortical circuitry poses fundamental challenges: visual contextual feedback is predominantly amplifying, and whether inhibitory circuits support selective subtraction is unknown. Here, we show how layer 2\/3 pyramidal neurons in mouse primary visual cortex can implement this comparison through plasticity that acts in opposite directions on responses to direct visual stimulation and contextual signals.<\/jats:p>\n                <jats:p>To dissociate these components, we presented full images to mice or images where one quadrant was occluded, removing direct visual stimulation while preserving surrounding contextual information, and measured pyramidal cell responses to these stimuli before and after visual familiarization.<\/jats:p>\n                <jats:p>After familiarization to non-occluded images, responses to direct visual inputs were selectively reduced, whereas contextual responses to occluded images strengthened. This strengthening generalized across natural scenes, allowing contextual inputs to also drive responses to novel occluded images and amplify responses to novel non-occluded images. A computational model reproduced these changes by weakening feedforward inputs and strengthening both feedforward-driven inhibition and contextual feedback in response to repeated pyramidal cell activity.<\/jats:p>\n                <jats:p>This context-contrasting mechanism produced a conserved structure of responses to occluded and non-occluded images across mice and previously acquired monkey and human data. Together, these results suggest a mechanism for saliency assignment that exploits the compartmental organization of cortical pyramidal neurons: they learn the generalized statistical structure of familiar contexts, allowing selective amplification of improbable inputs or omissions.<\/jats:p>","DOI":"10.1101\/2024.06.10.598181","type":"posted-content","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T22:45:12Z","timestamp":1718059512000},"source":"Crossref","is-referenced-by-count":3,"title":["Opposing plasticity mechanisms enhance visual inputs that violate their context"],"prefix":"10.64898","author":[{"given":"Koen","family":"Seignette","sequence":"first","affiliation":[{"name":"Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands"},{"name":"Department of Biology, Humboldt Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leander","family":"de Kraker","sequence":"additional","affiliation":[{"name":"Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0868-2232","authenticated-orcid":false,"given":"Mat\u00fa\u0161","family":"Hal\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands"},{"name":"Institute of Neuroinformatics, ETH Z\u00fcrich and University of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6249-841X","authenticated-orcid":false,"given":"Paolo","family":"Papale","sequence":"additional","affiliation":[{"name":"Department of Vision & Cognition, Netherlands Institute for Neuroscience, Amsterdam,the Netherlands"},{"name":"Department of Medicine and Surgery, Neuroscience Unit, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Dorlandt","sequence":"additional","affiliation":[{"name":"Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy S.","family":"Petro","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Neuroimaging, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK"},{"name":"Imaging Centre for Excellence (ICE), College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorrit S.","family":"Montijn","sequence":"additional","affiliation":[{"name":"Department of Cortical Structure & Function, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Self","sequence":"additional","affiliation":[{"name":"Department of Vision & Cognition, Netherlands Institute for Neuroscience, Amsterdam,the Netherlands"},{"name":"College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-1864","authenticated-orcid":false,"given":"Katharina A.","family":"Wilmes","sequence":"additional","affiliation":[{"name":"Institute of Neuroinformatics, ETH Z\u00fcrich and University of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-2656","authenticated-orcid":false,"given":"Matthew E.","family":"Larkum","sequence":"additional","affiliation":[{"name":"Department of Biology, Humboldt Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter R.","family":"Roelfsema","sequence":"additional","affiliation":[{"name":"Department of Vision & Cognition, Netherlands Institute for Neuroscience, Amsterdam,the Netherlands"},{"name":"Laboratory of Visual Brain Therapy, Sorbonne Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris, France"},{"name":"Department of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, VU University, Amsterdam, the Netherlands"},{"name":"Department of Neurosurgery, Academic University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0143-4324","authenticated-orcid":false,"given":"Lars F.","family":"Muckli","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Neuroimaging, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK"},{"name":"Imaging Centre for Excellence (ICE), College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan N.","family":"Levelt","sequence":"additional","affiliation":[{"name":"Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands"},{"name":"Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026102711101601000_2024.06.10.598181v4.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.057"},{"key":"2026102711101601000_2024.06.10.598181v4.2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-02-01605.1995"},{"key":"2026102711101601000_2024.06.10.598181v4.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2108882119"},{"key":"2026102711101601000_2024.06.10.598181v4.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07851-w"},{"key":"2026102711101601000_2024.06.10.598181v4.5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.celrep.2016.06.037","article-title":"Somatostatin Interneurons Control a Key Component of Mismatch Negativity in Mouse Visual Cortex","volume":"16","year":"2016","journal-title":"Cell Reports"},{"key":"2026102711101601000_2024.06.10.598181v4.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.12.007"},{"key":"2026102711101601000_2024.06.10.598181v4.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.040"},{"key":"2026102711101601000_2024.06.10.598181v4.8","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X12000477"},{"key":"2026102711101601000_2024.06.10.598181v4.9","doi-asserted-by":"publisher","DOI":"10.1038\/4580"},{"key":"2026102711101601000_2024.06.10.598181v4.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00076-X"},{"key":"2026102711101601000_2024.06.10.598181v4.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.10.003"},{"key":"2026102711101601000_2024.06.10.598181v4.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.038"},{"key":"2026102711101601000_2024.06.10.598181v4.13","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2016.01792"},{"key":"2026102711101601000_2024.06.10.598181v4.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.09.024"},{"key":"2026102711101601000_2024.06.10.598181v4.15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48924-8"},{"key":"2026102711101601000_2024.06.10.598181v4.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.11.006"},{"key":"2026102711101601000_2024.06.10.598181v4.17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.08.030185.002203"},{"key":"2026102711101601000_2024.06.10.598181v4.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.033"},{"key":"2026102711101601000_2024.06.10.598181v4.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.12.026"},{"key":"2026102711101601000_2024.06.10.598181v4.20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0468-17.2017"},{"key":"2026102711101601000_2024.06.10.598181v4.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.01.020"},{"key":"2026102711101601000_2024.06.10.598181v4.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.08.057"},{"key":"2026102711101601000_2024.06.10.598181v4.23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0852-19.2019"},{"key":"2026102711101601000_2024.06.10.598181v4.24","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neuroimage.2017.09.047","article-title":"Cortical feedback signals generalise across different spatial frequencies of feedforward inputs","volume":"180","year":"2018","journal-title":"NeuroImage"},{"key":"2026102711101601000_2024.06.10.598181v4.25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000233107"},{"key":"2026102711101601000_2024.06.10.598181v4.26","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3390\/biology12071022","article-title":"The Spatial Precision of Contextual Feedback Signals in Human V1","volume":"12","year":"2023","journal-title":"Biology"},{"key":"2026102711101601000_2024.06.10.598181v4.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2023.08.010"},{"key":"2026102711101601000_2024.06.10.598181v4.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00323-4"},{"key":"2026102711101601000_2024.06.10.598181v4.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.09.034"},{"key":"2026102711101601000_2024.06.10.598181v4.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.10.045"},{"key":"2026102711101601000_2024.06.10.598181v4.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2319-4"},{"key":"2026102711101601000_2024.06.10.598181v4.32","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add2498"},{"key":"2026102711101601000_2024.06.10.598181v4.33","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4061"},{"key":"2026102711101601000_2024.06.10.598181v4.34","doi-asserted-by":"crossref","first-page":"110413","DOI":"10.1016\/j.celrep.2022.110413","article-title":"Feature selectivity can explain mismatch signals in mouse visual cortex","volume":"38","year":"2022","journal-title":"Cell Rep"},{"key":"2026102711101601000_2024.06.10.598181v4.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2024.09.002"},{"key":"2026102711101601000_2024.06.10.598181v4.36","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5297.221"},{"key":"2026102711101601000_2024.06.10.598181v4.37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.2.719"},{"key":"2026102711101601000_2024.06.10.598181v4.38","doi-asserted-by":"publisher","DOI":"10.1038\/nature09160"},{"key":"2026102711101601000_2024.06.10.598181v4.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.066"},{"key":"2026102711101601000_2024.06.10.598181v4.40","doi-asserted-by":"publisher","DOI":"10.1038\/9165"},{"key":"2026102711101601000_2024.06.10.598181v4.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.02.031"},{"key":"2026102711101601000_2024.06.10.598181v4.42","doi-asserted-by":"publisher","DOI":"10.1038\/nature13321"},{"key":"2026102711101601000_2024.06.10.598181v4.43","doi-asserted-by":"publisher","DOI":"10.1101\/2020.11.30.403840"},{"key":"2026102711101601000_2024.06.10.598181v4.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.04.034"},{"key":"2026102711101601000_2024.06.10.598181v4.45","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj100"},{"key":"2026102711101601000_2024.06.10.598181v4.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.11.006"},{"key":"2026102711101601000_2024.06.10.598181v4.47","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3136"},{"key":"2026102711101601000_2024.06.10.598181v4.48","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_01135"},{"key":"2026102711101601000_2024.06.10.598181v4.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2018.06.002"},{"key":"2026102711101601000_2024.06.10.598181v4.50","doi-asserted-by":"crossref","first-page":"kvac013","DOI":"10.1093\/oons\/kvac013","article-title":"Dampened sensory representations for expected input across the ventral visual stream","volume":"1","year":"2022","journal-title":"Oxford Open Neuroscience"},{"key":"2026102711101601000_2024.06.10.598181v4.51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002577"},{"key":"2026102711101601000_2024.06.10.598181v4.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.06.033"},{"key":"2026102711101601000_2024.06.10.598181v4.53","doi-asserted-by":"publisher","DOI":"10.1126\/science.ads4706"},{"key":"2026102711101601000_2024.06.10.598181v4.54","doi-asserted-by":"publisher","DOI":"10.1038\/nature13664"},{"key":"2026102711101601000_2024.06.10.598181v4.55","doi-asserted-by":"crossref","first-page":"113133","DOI":"10.1016\/j.celrep.2023.113133","article-title":"Top-down input modulates visual context processing through an interneuron-specific circuit","volume":"42","year":"2023","journal-title":"Cell Rep"},{"key":"2026102711101601000_2024.06.10.598181v4.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.10.049"},{"key":"2026102711101601000_2024.06.10.598181v4.57","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2264-4"},{"key":"2026102711101601000_2024.06.10.598181v4.58","doi-asserted-by":"crossref","unstructured":"Cuevas, N. et al. Stimulus-specificity of surround-induced responses in primary visual cortex. eLife 13, (2025).","DOI":"10.7554\/eLife.99605"},{"key":"2026102711101601000_2024.06.10.598181v4.59","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2876"},{"key":"2026102711101601000_2024.06.10.598181v4.60","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1038\/s41593-025-02055-5","article-title":"Recurrent pattern completion drives the neocortical representation of sensory inference","volume":"28","year":"2025","journal-title":"Nat Neurosci"},{"key":"2026102711101601000_2024.06.10.598181v4.61","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150343"},{"key":"2026102711101601000_2024.06.10.598181v4.62","doi-asserted-by":"publisher","DOI":"10.1038\/18686"},{"key":"2026102711101601000_2024.06.10.598181v4.63","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1717-07.2007"},{"key":"2026102711101601000_2024.06.10.598181v4.64","doi-asserted-by":"crossref","first-page":"100129","DOI":"10.1016\/j.crneur.2024.100129","article-title":"Cellular mechanisms of cooperative context-sensitive predictive inference","volume":"6","year":"2024","journal-title":"Curr Res Neurobiol"},{"key":"2026102711101601000_2024.06.10.598181v4.65","doi-asserted-by":"publisher","DOI":"10.1093\/nc\/niab036"},{"key":"2026102711101601000_2024.06.10.598181v4.66","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1016\/j.neuron.2024.07.009","article-title":"Visual experience reduces the spatial redundancy between cortical feedback inputs and primary visual cortex neurons","volume":"112","year":"2024","journal-title":"Neuron"},{"key":"2026102711101601000_2024.06.10.598181v4.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2026.01.031"},{"key":"2026102711101601000_2024.06.10.598181v4.68","doi-asserted-by":"crossref","unstructured":"Summerfield, C. , Wyart, V. , Johnen, V. M. & De Gardelle, V . Human Scalp Electroencephalography Reveals that Repetition Suppression Varies with Expectation. Front. Hum. Neurosci. 5, (2011).","DOI":"10.3389\/fnhum.2011.00067"},{"key":"2026102711101601000_2024.06.10.598181v4.69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112895108"},{"key":"2026102711101601000_2024.06.10.598181v4.70","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2227-12.2012"},{"key":"2026102711101601000_2024.06.10.598181v4.71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117807108"},{"key":"2026102711101601000_2024.06.10.598181v4.72","unstructured":"Von Helmholtz, H . Handbuch der physiologischen Optik. (1867)."},{"key":"2026102711101601000_2024.06.10.598181v4.73","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-100223-121214"},{"key":"2026102711101601000_2024.06.10.598181v4.74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223792"},{"key":"2026102711101601000_2024.06.10.598181v4.75","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24311-5"},{"key":"2026102711101601000_2024.06.10.598181v4.76","doi-asserted-by":"crossref","first-page":"100299","DOI":"10.1016\/j.crmeth.2022.100299","article-title":"SpecSeg is a versatile toolbox that segments neurons and neurites in chronic calcium imaging datasets based on low-frequency cross-spectral power","volume":"2","year":"2022","journal-title":"Cell Reports Methods"},{"key":"2026102711101601000_2024.06.10.598181v4.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2017.07.031"},{"key":"2026102711101601000_2024.06.10.598181v4.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.04.032"},{"key":"2026102711101601000_2024.06.10.598181v4.79","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.453"},{"key":"2026102711101601000_2024.06.10.598181v4.80","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp211"},{"key":"2026102711101601000_2024.06.10.598181v4.81","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh065"},{"key":"2026102711101601000_2024.06.10.598181v4.82","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01490-6"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2024.06.10.598181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:10:28Z","timestamp":1793124628000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2024.06.10.598181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":82,"URL":"https:\/\/doi.org\/10.1101\/2024.06.10.598181","relation":{},"subject":[],"published":{"date-parts":[[2024,6,10]]},"subtype":"preprint"}}