{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:14:12Z","timestamp":1790280852223,"version":"4.1.0"},"posted":{"date-parts":[[2024,6,13]]},"group-title":"Cell Biology","reference-count":110,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 HL082792"],"award-info":[{"award-number":["R01 HL082792"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AR084664"],"award-info":[{"award-number":["R01 AR084664"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R35 GM153257"],"award-info":[{"award-number":["R35 GM153257"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 HL160028"],"award-info":[{"award-number":["R01 HL160028"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AI176681"],"award-info":[{"award-number":["R01 AI176681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000001","name":"U.S. National Science Foundation","doi-asserted-by":"crossref","award":["MCB-1715606"],"award-info":[{"award-number":["MCB-1715606"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000001","name":"U.S. National Science Foundation","doi-asserted-by":"crossref","award":["URoL-2022048"],"award-info":[{"award-number":["URoL-2022048"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"crossref"}]},{"award":["A130142"],"award-info":[{"award-number":["A130142"]}],"id":[{"id":"https:\/\/ror.org\/03bsmfz84","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["20POST35210660"],"award-info":[{"award-number":["20POST35210660"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["23POST1023021"],"award-info":[{"award-number":["23POST1023021"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"crossref","award":["20CVD01"],"award-info":[{"award-number":["20CVD01"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"crossref","award":["24CVD03"],"award-info":[{"award-number":["24CVD03"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Mutations in the\n                  <jats:italic>LMNA<\/jats:italic>\n                  gene, which encodes the nuclear envelope (NE) proteins lamins A and C, cause dilated cardiomyopathy (\n                  <jats:italic>LMNA<\/jats:italic>\n                  -DCM) and other diseases. The pathogenic mechanisms for\n                  <jats:italic>LMNA<\/jats:italic>\n                  -DCM remain poorly understood, limiting current treatment options and leading to high mortality amongst patients. We developed a mouse model with inducible, cardiomyocyte-specific\n                  <jats:italic>Lmna<\/jats:italic>\n                  deletion (cKO) and performed comprehensive bulk, single-nucleus, and spatial transcriptomic analyses across disease progression. Our analysis identified key disease-driving genes involved in cellular responses to DNA damage, cytosolic pattern recognition receptor signaling, and innate immunity that originated from two disease-specific cardiomyocyte subpopulations. Spatial mapping revealed aberrant interactions between these cardiomyocytes, fibroblasts, and immune cells, contributing to tissue-wide transcriptional changes in cKO hearts. Concurrent cardiomyocyte-specific disruption of the LINC complex, which transmits cytoskeletal forces to the nucleus, substantially reduced NE rupture in cKO cardiomyocytes, normalized expression of more than half of the dysregulated genes, and dramatically improved cardiac function and survival in cKO mice. These findings suggest that NE rupture in cKO cardiomyocytes triggers cytosolic DNA sensing pathways and maladaptive cell-cell communication with fibroblasts and immune cells, leading to fibrosis and inflammation driving\n                  <jats:italic>LMNA<\/jats:italic>\n                  -DCM pathogenesis.\n                <\/jats:p>","DOI":"10.1101\/2024.06.11.598511","type":"posted-content","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T06:10:21Z","timestamp":1718259021000},"source":"Crossref","is-referenced-by-count":8,"title":["Nuclear envelope rupture in cardiomyocytes orchestrates early transcriptomic changes and immune activation in\n                  <i>LMNA<\/i>\n                  -related dilated cardiomyopathy that are reversed by LINC complex disruption"],"prefix":"10.64898","author":[{"given":"Noam","family":"Zuela-Sopilniak","sequence":"first","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"},{"name":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien L.P.","family":"Morival","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"},{"name":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4157-1665","authenticated-orcid":false,"given":"Ioannis","family":"Ntekas","sequence":"additional","affiliation":[{"name":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Elpers","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"},{"name":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Henretta","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"},{"name":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob D.","family":"Odell","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"},{"name":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwijn","family":"De Vlaminck","sequence":"additional","affiliation":[{"name":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4335-8611","authenticated-orcid":false,"given":"Jan","family":"Lammerding","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA"},{"name":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026032713350827000_2024.06.11.598511v3.1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.203430"},{"key":"2026032713350827000_2024.06.11.598511v3.2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20170236"},{"key":"2026032713350827000_2024.06.11.598511v3.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2017.08.004"},{"key":"2026032713350827000_2024.06.11.598511v3.4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cardfail.2014.12.003","article-title":"A novel mutation in lamin a\/c causing familial dilated cardiomyopathy associated with sudden cardiac death","volume":"21","year":"2015","journal-title":"J Card Fail"},{"key":"2026032713350827000_2024.06.11.598511v3.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0589-1"},{"key":"2026032713350827000_2024.06.11.598511v3.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01724-2"},{"key":"2026032713350827000_2024.06.11.598511v3.7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2000.01661.x"},{"key":"2026032713350827000_2024.06.11.598511v3.8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev-pathol-042220-034240","article-title":"Molecular Pathology of Laminopathies","volume":"17","year":"2022","journal-title":"Annu. Rev. Pathol. Mech. Dis"},{"key":"2026032713350827000_2024.06.11.598511v3.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0563-5"},{"key":"2026032713350827000_2024.06.11.598511v3.10","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1038\/s44161-025-00727-w","article-title":"Microtubule forces drive nuclear damage in LMNA cardiomyopathy. Nat","volume":"4","year":"2025","journal-title":"Cardiovasc. Res"},{"key":"2026032713350827000_2024.06.11.598511v3.11","first-page":"mbcE21100527","article-title":"Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope","volume":"34","year":"2023","journal-title":"Mol Biol Cell"},{"key":"2026032713350827000_2024.06.11.598511v3.12","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201901116"},{"key":"2026032713350827000_2024.06.11.598511v3.13","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E20-01-0009"},{"key":"2026032713350827000_2024.06.11.598511v3.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2021.07.008"},{"key":"2026032713350827000_2024.06.11.598511v3.15","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01546-5"},{"key":"2026032713350827000_2024.06.11.598511v3.16","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jare.2025.01.001","article-title":"LMNA-related cardiomyopathy: From molecular pathology to cardiac gene therapy","volume":"77","year":"2025","journal-title":"J. Adv. Res"},{"key":"2026032713350827000_2024.06.11.598511v3.17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.24272\/j.issn.2095-8137.2022.464","article-title":"Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases","volume":"44","year":"2023","journal-title":"Zool Res"},{"key":"2026032713350827000_2024.06.11.598511v3.18","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00589-6"},{"key":"2026032713350827000_2024.06.11.598511v3.19","doi-asserted-by":"publisher","DOI":"10.1042\/BST20110686"},{"key":"2026032713350827000_2024.06.11.598511v3.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2023.11.001"},{"key":"2026032713350827000_2024.06.11.598511v3.21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.233700"},{"key":"2026032713350827000_2024.06.11.598511v3.22","doi-asserted-by":"publisher","DOI":"10.1080\/19491034.2019.1595313"},{"key":"2026032713350827000_2024.06.11.598511v3.23","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22755"},{"key":"2026032713350827000_2024.06.11.598511v3.24","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-021-04344-9"},{"key":"2026032713350827000_2024.06.11.598511v3.25","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"2026032713350827000_2024.06.11.598511v3.26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"2026032713350827000_2024.06.11.598511v3.27","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"2026032713350827000_2024.06.11.598511v3.28","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14049"},{"key":"2026032713350827000_2024.06.11.598511v3.29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67513-5"},{"key":"2026032713350827000_2024.06.11.598511v3.30","doi-asserted-by":"publisher","DOI":"10.1038\/S41587-023-01767-Y"},{"key":"2026032713350827000_2024.06.11.598511v3.31","doi-asserted-by":"crossref","unstructured":"Hocker JD , Poirion OB , Zhu F , Buchanan J , Zhang K , Chiou J , Wang TM , Zhang Q , Hou X , Li YE , et al. Cardiac cell type-specific gene regulatory programs and disease risk association. Sci Adv. 2021;7.","DOI":"10.1126\/sciadv.abf1444"},{"key":"2026032713350827000_2024.06.11.598511v3.32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s44161-022-00028-6","article-title":"Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure","volume":"1","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"2026032713350827000_2024.06.11.598511v3.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2797-4"},{"key":"2026032713350827000_2024.06.11.598511v3.34","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-024-01045-4"},{"key":"2026032713350827000_2024.06.11.598511v3.35","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4772-0"},{"key":"2026032713350827000_2024.06.11.598511v3.36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"2026032713350827000_2024.06.11.598511v3.37","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"2026032713350827000_2024.06.11.598511v3.38","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo1984"},{"key":"2026032713350827000_2024.06.11.598511v3.39","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1142"},{"key":"2026032713350827000_2024.06.11.598511v3.40","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1382-0"},{"key":"2026032713350827000_2024.06.11.598511v3.41","doi-asserted-by":"crossref","unstructured":"Kaminow B , Yunusov D , Dobin A . STARsolo: accurate, fast and versatile mapping\/quantification of single-cell and single-nucleus RNA-seq data [Internet]. 2021 [cited 2025 Sept 13];2021.05.05.442755. Available from: https:\/\/www.biorxiv.org\/content\/10.1101\/2021.05.05.442755v1","DOI":"10.1101\/2021.05.05.442755"},{"key":"2026032713350827000_2024.06.11.598511v3.42","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01139-4"},{"key":"2026032713350827000_2024.06.11.598511v3.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01358-2"},{"key":"2026032713350827000_2024.06.11.598511v3.44","doi-asserted-by":"crossref","unstructured":"Jimenez-Alcantara I , Lozano-Velasco E , Cano-Carrillo S , Castillo-Casas JM , Garcia-Ruano AB , Segura-Aumente JM , Urbano-Moral JA , Franco D . LMNA p.Arg624His Variant Reduces Lamin Expression at mRNA Level: Elucidating Molecular Pathways toward Cardiac Involvement in Laminopathies. J Cardiovasc Transl Res. 2024;","DOI":"10.1093\/cvr\/cvae088.114"},{"key":"2026032713350827000_2024.06.11.598511v3.45","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.5.913"},{"key":"2026032713350827000_2024.06.11.598511v3.46","doi-asserted-by":"crossref","unstructured":"Sztretye M , Szabo L , Dobrosi N , Fodor J , Szentesi P , Almassy J , Magyar ZE , Dienes B , Csernoch L . From Mice to Humans: An Overview of the Potentials and Limitations of Current Transgenic Mouse Models of Major Muscular Dystrophies and Congenital Myopathies. Int J Mol Sci. 2020;21.","DOI":"10.3390\/ijms21238935"},{"key":"2026032713350827000_2024.06.11.598511v3.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2007.03.026"},{"key":"2026032713350827000_2024.06.11.598511v3.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114284"},{"key":"2026032713350827000_2024.06.11.598511v3.49","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs191"},{"key":"2026032713350827000_2024.06.11.598511v3.50","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12021"},{"key":"2026032713350827000_2024.06.11.598511v3.51","first-page":"309","article-title":"Dilated cardiomyopathy produced by lamin A\/C gene mutations","volume":"86","year":"2013","journal-title":"Clujul Med"},{"key":"2026032713350827000_2024.06.11.598511v3.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.059"},{"key":"2026032713350827000_2024.06.11.598511v3.53","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0865-4"},{"key":"2026032713350827000_2024.06.11.598511v3.54","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"2026032713350827000_2024.06.11.598511v3.55","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29042"},{"key":"2026032713350827000_2024.06.11.598511v3.56","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1021\/acs.jproteome.3c00853","article-title":"Global Proteomic Analysis Reveals Alterations in Differentially Expressed Proteins between Cardiopathic Lamin A\/C Mutations","volume":"23","year":"2024","journal-title":"J Proteome Res"},{"key":"2026032713350827000_2024.06.11.598511v3.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.04.020"},{"key":"2026032713350827000_2024.06.11.598511v3.58","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-010-0085-4"},{"key":"2026032713350827000_2024.06.11.598511v3.59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200419448"},{"key":"2026032713350827000_2024.06.11.598511v3.60","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad7297"},{"key":"2026032713350827000_2024.06.11.598511v3.61","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-022-01431-x"},{"key":"2026032713350827000_2024.06.11.598511v3.62","doi-asserted-by":"publisher","DOI":"10.1038\/nature25432"},{"key":"2026032713350827000_2024.06.11.598511v3.63","doi-asserted-by":"crossref","first-page":"116698","DOI":"10.1016\/j.biopha.2024.116698","article-title":"Relationship between the cGAS\u2212STING and NF-\u03baB pathways-role in neurotoxicity","volume":"175","year":"2024","journal-title":"Biomed. Pharmacother"},{"key":"2026032713350827000_2024.06.11.598511v3.64","doi-asserted-by":"crossref","unstructured":"Baldarelli RM , Smith CL , Ringwald M , Richardson JE , Bult CJ , Mouse Genome Informatics G. Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse. Genetics. 2024;227.","DOI":"10.1093\/genetics\/iyae031"},{"key":"2026032713350827000_2024.06.11.598511v3.65","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402006"},{"key":"2026032713350827000_2024.06.11.598511v3.66","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41580-022-00480-z","article-title":"Mechanics and functional consequences of nuclear deformations","volume":"23","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026032713350827000_2024.06.11.598511v3.67","doi-asserted-by":"crossref","unstructured":"Mannino PJ , Lusk CP . Quality control mechanisms that protect nuclear envelope identity and function. J Cell Biol. 2022;221.","DOI":"10.1083\/jcb.202205123"},{"key":"2026032713350827000_2024.06.11.598511v3.68","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mad.2016.09.001","article-title":"Sensing of dangerous DNA","volume":"165","year":"2017","journal-title":"Mech. Ageing Dev"},{"key":"2026032713350827000_2024.06.11.598511v3.69","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41420-024-01978-5","article-title":"The role of IFI16 in regulating PANoptosis and implication in heart diseases","volume":"10","year":"2024","journal-title":"Cell Death Discov"},{"key":"2026032713350827000_2024.06.11.598511v3.70","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41392-025-02174-2","article-title":"Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy","volume":"10","year":"2025","journal-title":"Signal Transduct. Target. Ther"},{"key":"2026032713350827000_2024.06.11.598511v3.71","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12669"},{"key":"2026032713350827000_2024.06.11.598511v3.72","doi-asserted-by":"crossref","unstructured":"Wang E , Zhou R , Li T , Hua Y , Zhou K , Li Y , Luo S , An Q . The Molecular Role of Immune Cells in Dilated Cardiomyopathy. Med. Kaunas. 2023;59.","DOI":"10.3390\/medicina59071246"},{"key":"2026032713350827000_2024.06.11.598511v3.73","doi-asserted-by":"crossref","first-page":"10902","DOI":"10.1111\/jcmm.16975","article-title":"Pro-inflammatory cytokines as emerging molecular determinants in cardiolaminopathies","volume":"25","year":"2021","journal-title":"J Cell Mol Med"},{"key":"2026032713350827000_2024.06.11.598511v3.74","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319737"},{"key":"2026032713350827000_2024.06.11.598511v3.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.03.002"},{"key":"2026032713350827000_2024.06.11.598511v3.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.11.002"},{"key":"2026032713350827000_2024.06.11.598511v3.77","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00123"},{"key":"2026032713350827000_2024.06.11.598511v3.78","doi-asserted-by":"crossref","unstructured":"Jin B , Zhu J , Shi H-M , Wen Z-C , Wu B-W . YAP activation promotes the transdifferentiation of cardiac fibroblasts to myofibroblasts in matrix remodeling of dilated cardiomyopathy. Braz. J. Med. Biol. Res. [Internet]. 2019 [cited 2025 Sept 12];52. Available from: https:\/\/www.scielo.br\/j\/bjmbr\/a\/t6DwXxRFzfBcCqGTxgVCmqj\/?lang=en","DOI":"10.1590\/1414-431x20187914"},{"key":"2026032713350827000_2024.06.11.598511v3.79","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22755"},{"key":"2026032713350827000_2024.06.11.598511v3.80","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181e74a14"},{"key":"2026032713350827000_2024.06.11.598511v3.81","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24849-4"},{"key":"2026032713350827000_2024.06.11.598511v3.82","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev-pathol-042220-034240","article-title":"Molecular Pathology of Laminopathies","volume":"17","year":"2022","journal-title":"Annu. Rev. Pathol. Mech. Dis"},{"key":"2026032713350827000_2024.06.11.598511v3.83","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314238"},{"key":"2026032713350827000_2024.06.11.598511v3.84","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jacbts.2022.06.015","article-title":"Genetic Ablation of the DNA Damage Response Pathway Attenuates Lamin-Associated Dilated Cardiomyopathy in Mice","volume":"7","year":"2022","journal-title":"JACC Basic Transl Sci"},{"key":"2026032713350827000_2024.06.11.598511v3.85","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41420-024-01998-1","article-title":"Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in lamin A\/C-deficient mice","volume":"10","year":"2024","journal-title":"Cell Death Discov"},{"key":"2026032713350827000_2024.06.11.598511v3.86","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314177"},{"key":"2026032713350827000_2024.06.11.598511v3.87","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13148-021-01127-0","article-title":"DNA methylation analysis reveals epimutation hotspots in patients with dilated cardiomyopathy-associated laminopathies","volume":"13","year":"2021","journal-title":"Clin. Epigenetics"},{"key":"2026032713350827000_2024.06.11.598511v3.88","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddac179"},{"key":"2026032713350827000_2024.06.11.598511v3.89","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006765117"},{"key":"2026032713350827000_2024.06.11.598511v3.90","doi-asserted-by":"publisher","DOI":"10.3390\/v3060920"},{"key":"2026032713350827000_2024.06.11.598511v3.91","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern recognition receptors in health and diseases","volume":"6","year":"2021","journal-title":"Signal Transduct. Target. Ther"},{"key":"2026032713350827000_2024.06.11.598511v3.92","unstructured":"Bonne G . The UMD-LMNA mutations database [Internet]. 2020;Available from: http:\/\/www.umd.be\/LMNA\/"},{"key":"2026032713350827000_2024.06.11.598511v3.93","first-page":"e13794","article-title":"The Dual Roles of Lamin A\/C in Macrophage Mechanotransduction","volume":"58","year":"2024","journal-title":"Cell Prolif"},{"key":"2026032713350827000_2024.06.11.598511v3.94","doi-asserted-by":"crossref","first-page":"30","DOI":"10.20517\/jca.2022.14","article-title":"Deletion of the Lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype","volume":"2","year":"2022","journal-title":"J. Cardiovasc. Aging"},{"key":"2026032713350827000_2024.06.11.598511v3.95","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"2026032713350827000_2024.06.11.598511v3.96","unstructured":"Stephens M , Carbonetto P , Dai C , Gerard D , Lu M , Sun L , Willwerscheid J , Xiao N , Zeng M . ashr: Methods for Adaptive Shrinkage, using Emperical Bayes. 2023;"},{"key":"2026032713350827000_2024.06.11.598511v3.97","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00805-7"},{"key":"2026032713350827000_2024.06.11.598511v3.98","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing [Internet]. 2021;Available from: https:\/\/www.R-project.org\/"},{"key":"2026032713350827000_2024.06.11.598511v3.99","doi-asserted-by":"crossref","unstructured":"Young MD , Behjati S . SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data. Gigascience. 2020;9.","DOI":"10.1093\/gigascience\/giaa151"},{"key":"2026032713350827000_2024.06.11.598511v3.100","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors","volume":"8","year":"2019","journal-title":"Cell Syst"},{"key":"2026032713350827000_2024.06.11.598511v3.101","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2021.04.048"},{"key":"2026032713350827000_2024.06.11.598511v3.102","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyad031"},{"key":"2026032713350827000_2024.06.11.598511v3.103","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baw100"},{"key":"2026032713350827000_2024.06.11.598511v3.104","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1080"},{"key":"2026032713350827000_2024.06.11.598511v3.105","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","year":"2011","journal-title":"EMBnet.journal"},{"key":"2026032713350827000_2024.06.11.598511v3.106","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw1219"},{"key":"2026032713350827000_2024.06.11.598511v3.107","unstructured":"Sofroniew N , Lambert T , Bokota G , Nunez-Iglesias J , Sobolewski P , Sweet A , Gaifas L , Evans K , Burt A , Doncila Pop D , et al. napari: a multi-dimensional image viewer for Python [Internet]. 2025 [cited 2025 Sept 13];Available from: https:\/\/zenodo.org\/records\/15779115"},{"key":"2026032713350827000_2024.06.11.598511v3.108","doi-asserted-by":"crossref","unstructured":"Holdener C , De Vlaminck I . Smoothie: Efficient Inference of Spatial Co-expression Networks from Denoised Spatial Transcriptomics Data. BioRxiv Prepr. Serv. Biol. 2025;2025.02.26.640406.","DOI":"10.1101\/2025.02.26.640406"},{"key":"2026032713350827000_2024.06.11.598511v3.109","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.21105\/joss.03021","article-title":"seaborn: statistical data visualization","volume":"6","year":"2021","journal-title":"J. Open Source Softw."},{"key":"2026032713350827000_2024.06.11.598511v3.110","unstructured":"Kassambara A . ggpubr: \u201cggplot2\u201d Based Publication Ready Plots. R package version 0.6.0. 2023;"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2024.06.11.598511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T20:35:24Z","timestamp":1774643724000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2024.06.11.598511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,13]]},"references-count":110,"URL":"https:\/\/doi.org\/10.1101\/2024.06.11.598511","relation":{},"subject":[],"published":{"date-parts":[[2024,6,13]]},"subtype":"preprint"}}