{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:36:46Z","timestamp":1768513006417,"version":"3.49.0"},"posted":{"date-parts":[[2024,6,16]]},"group-title":"Immunology","reference-count":75,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,6,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Patients with cutaneous T cell lymphoma (CTCL) experience high morbidity and mortality due to\n                  <jats:italic>S. aureus<\/jats:italic>\n                  skin infections and sepsis, but the causative immune defect is unclear. We previously identified high levels of LAIR2, a decoy protein for the inhibitory receptor LAIR1, in advanced CTCL. Mice do not have a LAIR2 homolog, so we used\n                  <jats:italic>Lair1<\/jats:italic>\n                  knock-out (KO) mice to model LAIR2 overexpression. In a model of subcutaneous\n                  <jats:italic>S. aureus<\/jats:italic>\n                  skin infection,\n                  <jats:italic>Lair1<\/jats:italic>\n                  KO mice had significantly larger abscesses and areas of dermonecrosis compared to WT.\n                  <jats:italic>Lair1<\/jats:italic>\n                  KO exhibited a pattern of increased inflammatory responses in infection and sterile immune stimulation, including increased production of proinflammatory cytokines and myeloid chemokines, neutrophil ROS, and collagen\/ECM remodeling pathways. Notably,\n                  <jats:italic>Lair1<\/jats:italic>\n                  KO infected skin had a similar bacterial burden and neutrophils and monocytes had equivalent\n                  <jats:italic>S. aureus<\/jats:italic>\n                  phagocytosis compared to WT. These findings support a model in which lack of LAIR1 signaling causes an excessive inflammatory response that does not improve infection control. CTCL skin lesions harbored similar patterns of increased expression in cytokine and collagen\/ECM remodeling pathways, suggesting that high levels of LAIR2 in CTCL recapitulates\n                  <jats:italic>Lair1<\/jats:italic>\n                  KO, causing inflammatory tissue damage and compromising host defense against\n                  <jats:italic>S. aureus<\/jats:italic>\n                  infection.\n                <\/jats:p>","DOI":"10.1101\/2024.06.13.598864","type":"posted-content","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T03:35:11Z","timestamp":1718595311000},"source":"Crossref","is-referenced-by-count":2,"title":["LAIR1 prevents excess inflammatory tissue damage in\n                  <i>S. aureus<\/i>\n                  skin infection and Cutaneous T-cell Lymphoma"],"prefix":"10.64898","author":[{"given":"Hannah K.","family":"Dorando","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan C.","family":"Mutic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly L.","family":"Tomaszewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mellisa K.","family":"Stefanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaz C.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah J.","family":"Veis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane Bubeck","family":"Wardenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy C.","family":"Musiek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Mehta-Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8832-3661","authenticated-orcid":false,"given":"Jacqueline E.","family":"Payton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"issue":"1","key":"2024062101300704000_2024.06.13.598864v1.1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41572-021-00296-9","article-title":"Cutaneous T cell lymphoma","volume":"7","year":"2021","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"2024062101300704000_2024.06.13.598864v1.2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1001\/jamadermatol.2022.5740","article-title":"Characteristics and Outcomes for Hospitalized Patients With Cutaneous T-Cell Lymphoma","volume":"159","year":"2023","journal-title":"JAMA Dermatol"},{"issue":"11","key":"2024062101300704000_2024.06.13.598864v1.3","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1080\/10428194.2020.1779259","article-title":"Risk of bacteremia in patients with cutaneous T-cell lymphoma (CTCL)","volume":"61","year":"2020","journal-title":"Leuk Lymphoma"},{"key":"2024062101300704000_2024.06.13.598864v1.4","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3488"},{"key":"2024062101300704000_2024.06.13.598864v1.5","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124233"},{"key":"2024062101300704000_2024.06.13.598864v1.6","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000243"},{"key":"2024062101300704000_2024.06.13.598864v1.7","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-17-0270"},{"key":"2024062101300704000_2024.06.13.598864v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.07.053"},{"key":"2024062101300704000_2024.06.13.598864v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80530-0"},{"issue":"3","key":"2024062101300704000_2024.06.13.598864v1.10","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.4049\/jimmunol.180.3.1662","article-title":"The Soluble Leukocyte-Associated Ig-Like Receptor (LAIR)-2 Antagonizes the Collagen\/LAIR-1 Inhibitory Immune Interaction","volume":"180","year":"2008","journal-title":"The Journal of Immunology"},{"key":"2024062101300704000_2024.06.13.598864v1.11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3389\/fimmu.2018.00453","article-title":"C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules","volume":"9","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"2024062101300704000_2024.06.13.598864v1.12","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0907609"},{"key":"2024062101300704000_2024.06.13.598864v1.13","doi-asserted-by":"crossref","unstructured":"Dorando HK , et al. 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