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A Treg subtype specialized in controlling Th1-cell responses and another known to control responses in B-cell follicles were substantial components of this compartment, foretelling that punctual Treg-cell ablation rapidly unleashed interferon-gamma production by meningeal lymphocytes, unlocked their access to the brain parenchyma, and altered meningeal B-cell profiles. Distally, the hippocampus assumed a reactive state, with morphological and transcriptional changes in multiple glial-cell types; within the dentate gyrus, neural stem cells showed exacerbated death and desisted from further differentiation, associated with inhibition of spatial-reference memory. Thus, meningeal Treg cells are a multifaceted bulwark to brain homeostasis at steady-state.<\/jats:p>\n                <jats:sec>\n                  <jats:title>One sentence summary<\/jats:title>\n                  <jats:p>A distinct population of regulatory T cells in the murine meninges safeguards homeostasis by keeping local interferon-\u03b3-producing lymphocytes in check, thereby preventing their invasion of the parenchyma, activation of hippocampal glial cells, death of neural stem cells, and memory decay.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2024.06.17.599387","type":"posted-content","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T04:25:12Z","timestamp":1718684712000},"source":"Crossref","is-referenced-by-count":2,"title":["The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis"],"prefix":"10.64898","author":[{"given":"Miguel","family":"Marin-Rodero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa Cintado","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec J.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teshika","family":"Jayewickreme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe A.","family":"Pinho-Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruaidhr\u00ed","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac M.","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Benoist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4226-1201","authenticated-orcid":false,"given":"Beth","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-5547","authenticated-orcid":false,"given":"Jos\u00e9 Lu\u00eds","family":"Trejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Mathis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024062019100629000_2024.06.17.599387v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.04.003"},{"key":"2024062019100629000_2024.06.17.599387v1.2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41586-022-05474-7","article-title":"Brain borders at the central stage of neuroimmunology","volume":"612","year":"2022","journal-title":"Nature"},{"key":"2024062019100629000_2024.06.17.599387v1.3","doi-asserted-by":"crossref","unstructured":"A. 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