{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:07:49Z","timestamp":1782922069774,"version":"3.54.5"},"posted":{"date-parts":[[2024,6,20]]},"group-title":"Neurology","reference-count":98,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Dissecting biological pathways highlighted by Mendelian gene discovery has provided critical insights into the pathogenesis of Parkinson\u2019s disease (PD) and neurodegeneration. This approach ultimately catalyzes the identification of potential biomarkers and therapeutic targets. Here, we identify\n                  <jats:italic>PSMF1<\/jats:italic>\n                  as a novel gene implicated in parkinsonism and childhood neurodegeneration. We find that biallelic\n                  <jats:italic>PSMF1<\/jats:italic>\n                  missense and loss-of-function variants co-segregate with phenotypes from early-onset PD to perinatal lethality with neurological manifestations across 17 pedigrees with 24 affected subjects, showing clear genotype-phenotype correlation.\n                  <jats:italic>PSMF1<\/jats:italic>\n                  encodes the proteasome regulator PSMF1\/PI31, a highly conserved, ubiquitously expressed partner of the 20S proteasome and neurodegeneration-associated F-box-O 7 and valosin-containing proteins. We demonstrate that\n                  <jats:italic>PSMF1<\/jats:italic>\n                  variants impair mitochondrial membrane potential, dynamics and mitophagy, and may affect proteasomal abundance and assembly in patient-derived fibroblasts. Furthermore,\n                  <jats:italic>Drosophila<\/jats:italic>\n                  and mouse models of\n                  <jats:italic>PSMF1<\/jats:italic>\n                  loss of function exhibit age-dependent motor impairment, as well as brain-wide mitochondrial membrane depolarization and dopaminergic neurodegeneration in aged flies, and diffuse gliosis in mice. Collectively, our findings unequivocally link defective PSMF1 to early-onset parkinsonism and neurodegeneration, and suggest proteasomal and mitochondrial dysfunction as mechanistic contributors.\n                <\/jats:p>","DOI":"10.1101\/2024.06.19.24308302","type":"posted-content","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T14:50:14Z","timestamp":1718895014000},"source":"Crossref","is-referenced-by-count":6,"title":["Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from early-onset Parkinson\u2019s disease to perinatal lethality and disrupt mitochondrial function"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4706-6245","authenticated-orcid":false,"given":"Francesca","family":"Magrinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7589-3710","authenticated-orcid":false,"given":"Christelle","family":"Tesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4596-9117","authenticated-orcid":false,"given":"Plamena R.","family":"Angelova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1813-1103","authenticated-orcid":false,"given":"Jose 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