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To enable this research, we explored 39 candidate biomarkers for menopausal status in 42 pre-, peri-, and post-menopausal subjects across three postmortem tissues: blood, the hypothalamus, and pituitary gland. We identified thirteen significant and seven strongest menopausal biomarkers across the three tissues. Using these biomarkers, we generated multi-tissue and tissue-specific composite measures that allow the postmortem identification of the menopausal status across different age ranges, including the \u201cperimenopausal\u201d, 45-55-year-old group. Our findings enable the study of cellular and molecular mechanisms underlying increased neuropsychiatric risk during the MT, opening the path for hormone status-informed, precision medicine approach in women\u2019s mental health.<\/jats:p>","DOI":"10.1101\/2024.06.20.599941","type":"posted-content","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T16:55:15Z","timestamp":1719248115000},"source":"Crossref","is-referenced-by-count":1,"title":["Postmortem tissue biomarkers of menopausal transition"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-8674","authenticated-orcid":false,"given":"Maria","family":"Tickerhoof","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-056X","authenticated-orcid":false,"given":"Heining","family":"Cham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anaya","family":"Ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonola","family":"Burrja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4799-7904","authenticated-orcid":false,"given":"Pavan","family":"Auluck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6565-0181","authenticated-orcid":false,"given":"Peter J.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2488-2365","authenticated-orcid":false,"given":"Stefano","family":"Marenco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-4217","authenticated-orcid":false,"given":"Marija","family":"Kundakovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024062604000738000_2024.06.20.599941v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00926-7"},{"key":"2024062604000738000_2024.06.20.599941v1.2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31824d8f40"},{"key":"2024062604000738000_2024.06.20.599941v1.3","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz283"},{"key":"2024062604000738000_2024.06.20.599941v1.4","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa513"},{"key":"2024062604000738000_2024.06.20.599941v1.5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1746"},{"key":"2024062604000738000_2024.06.20.599941v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.82"},{"key":"2024062604000738000_2024.06.20.599941v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.11.002"},{"key":"2024062604000738000_2024.06.20.599941v1.8","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0000000000001424"},{"key":"2024062604000738000_2024.06.20.599941v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2022.101010"},{"key":"2024062604000738000_2024.06.20.599941v1.10","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291722001143"},{"key":"2024062604000738000_2024.06.20.599941v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.10.006"},{"key":"2024062604000738000_2024.06.20.599941v1.12","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2018.20.3\/drubinow"},{"key":"2024062604000738000_2024.06.20.599941v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90084-y"},{"key":"2024062604000738000_2024.06.20.599941v1.14","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1300038"},{"key":"2024062604000738000_2024.06.20.599941v1.15","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.4.3.272"},{"key":"2024062604000738000_2024.06.20.599941v1.16","doi-asserted-by":"publisher","DOI":"10.5116\/ijme.5f96.0f4a"},{"key":"2024062604000738000_2024.06.20.599941v1.17","doi-asserted-by":"crossref","unstructured":"Pag\u00e8s, J. 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