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The IC is divided into two territories: the anterior IC (aIC), processing socioemotional signals, and the posterior IC (pIC), specializing in interoception and pain perception. Pyramidal neurons in the aIC and pIC exhibit sex-specific electrophysiological properties, including variations in excitability and the excitatory\/inhibitory balance. We investigated IC\u2019s cellular properties and synaptic strength in the offspring of both sexes from mice exposed to low-dose CBD during gestation (E5-E18; 3mg\/kg, s.c.). Prenatal CBD exposure induced sex-specific and territory-specific changes in the active and passive membrane properties, as well as intrinsic excitability and the excitatory\/inhibitory balance, in the IC of adult offspring. The data indicate that in-utero CBD exposure disrupts IC neuronal development, leading to a loss of functional distinction between IC territories. These findings may have significant implications for understanding the effects of CBD on emotional behaviors in offspring.<\/jats:p>","DOI":"10.1101\/2024.06.26.597499","type":"posted-content","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T06:05:11Z","timestamp":1719641111000},"source":"Crossref","is-referenced-by-count":1,"title":["Gestational CBD shapes insular cortex in adulthood"],"prefix":"10.64898","author":[{"given":"Daniela","family":"Iezzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"C\u00e1ceres-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Pereira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Chavis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5579-6208","authenticated-orcid":false,"given":"Olivier J.","family":"Manzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024070215001373000_2024.06.26.597499v1.1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.placenta.2023.03.002","article-title":"Cannabinoids and the placenta: Receptors, signaling and outcomes","volume":"135","year":"2023","journal-title":"Placenta"},{"key":"2024070215001373000_2024.06.26.597499v1.2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejim.2018.01.001","article-title":"Medical use of cannabis and cannabinoids containing products - Regulations in Europe and North America","volume":"49","year":"2018","journal-title":"Eur. 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