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However, T cell features associated with treatment response or resistance are poorly understood. Here we identify an essential role for cytotoxic T cells in mediating response to BsAb in B cell lymphomas. In a disseminated B cell lymphoma model, BsAb showed substantial anti-tumor efficacy, which was dependent on activation and expansion of CD8+ T cells. Analysis of primary tumor samples from BsAb-treated patients confirmed that CD8+ T cell abundance was associated with durable remission and identified CXCR6+ cytotoxic T cells as associated with complete response. Cxcr6 knockout abrogated BsAb efficacy despite activation of CD4+ and CD8+ T cells. These results link BsAb efficacy to tumor resident cytotoxic T cells and suggest that enhancing chemokine-dependent T cell recruitment may augment therapeutic efficacy.<\/jats:p>","DOI":"10.1101\/2024.07.02.24309792","type":"posted-content","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T11:45:23Z","timestamp":1720179923000},"source":"Crossref","is-referenced-by-count":7,"title":["CXCR6+ T cells are required for CD3xCD20 Bispecific Antibody Efficacy in B cell Lymphomas"],"prefix":"10.64898","author":[{"given":"Philipp","family":"Berning","sequence":"first","affiliation":[{"name":"Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY"},{"name":"Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Fukasawa","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology and Genetics, Sloan Kettering Institute, 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