{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T12:01:29Z","timestamp":1772452889589,"version":"3.50.1"},"posted":{"date-parts":[[2024,7,10]]},"group-title":"Evolutionary Biology","reference-count":108,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  <jats:italic>Aspergillus flavus<\/jats:italic>\n                  is a clinically and agriculturally important saprotrophic fungus responsible for severe human infections and extensive crop losses. We analyzed genomic data from 250 (95 clinical and 155 environmental)\n                  <jats:italic>A. flavus<\/jats:italic>\n                  isolates from 9 countries, including 70 newly sequenced clinical isolates, to examine population and pan-genome structure and their relationship to pathogenicity. We identified five\n                  <jats:italic>A. flavus<\/jats:italic>\n                  populations, including a new population, D, corresponding to distinct clades in the genome-wide phylogeny. Strikingly, &gt; 75% of clinical isolates were from population D. Accessory genes, including genes within biosynthetic gene clusters, were significantly more common in some populations but rare in others. Population D was enriched for genes associated with zinc ion binding, lipid metabolism, and certain types of hydrolase activity. In contrast to the major human pathogen\n                  <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                  ,\n                  <jats:italic>A. flavus<\/jats:italic>\n                  pathogenicity in humans is strongly associated with population structure, making it a great system for investigating how population-specific genes contribute to pathogenicity.\n                <\/jats:p>","DOI":"10.1101\/2024.07.05.602241","type":"posted-content","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T13:15:24Z","timestamp":1720617324000},"source":"Crossref","is-referenced-by-count":2,"title":["Pathogenicity is associated with population structure in a fungal pathogen of humans"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7821-8160","authenticated-orcid":false,"given":"E. 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