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We found that expression of MAGE-A4 was highly associated with the loss of\n                  <jats:italic>PTEN<\/jats:italic>\n                  , a tumor suppressor, in human NSCLC. Here we show that constitutive expression of human\n                  <jats:italic>MAGE-A4<\/jats:italic>\n                  combined with the loss of\n                  <jats:italic>Pten<\/jats:italic>\n                  in mouse airway epithelial cells results in metastatic adenocarcinoma enriched in CD138\n                  <jats:sup>+<\/jats:sup>\n                  CXCR4\n                  <jats:sup>+<\/jats:sup>\n                  plasma cells, predominantly expressing IgA. Consistently, human NSCLC expressing MAGE-A4 showed increased CD138\n                  <jats:sup>+<\/jats:sup>\n                  IgA\n                  <jats:sup>+<\/jats:sup>\n                  plasma cell density surrounding tumors. The abrogation of MAGE-A4-responsive plasma cells (MARPs) decreased tumor burden, increased T cell infiltration and activation, and reduced CD163\n                  <jats:sup>+<\/jats:sup>\n                  CD206\n                  <jats:sup>+<\/jats:sup>\n                  macrophages in mouse lungs. These findings suggest MAGE-A4 promotes NSCLC tumorigenesis, in part, through the recruitment and retention of IgA\n                  <jats:sup>+<\/jats:sup>\n                  MARPs in the lungs.\n                <\/jats:p>","DOI":"10.1101\/2024.07.10.602985","type":"posted-content","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T19:05:26Z","timestamp":1721156726000},"source":"Crossref","is-referenced-by-count":1,"title":["MAGE-A4-Responsive Plasma Cells Promote Non-Small Cell Lung Cancer"],"prefix":"10.64898","author":[{"given":"Dominique","family":"Armstrong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica J.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Zhen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Jammi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Casal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad J.","family":"Creighton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Carisey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-8670","authenticated-orcid":false,"given":"Xiang H.-F.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6689-0104","authenticated-orcid":false,"given":"Neil J.","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Wook","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Sung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Corry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrah","family":"Kheradmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"issue":"1","key":"2024071800200675000_2024.07.10.602985v1.1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41392-021-00572-w","article-title":"Small molecules in targeted cancer therapy: advances, challenges, and future perspectives","volume":"6","year":"2021","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"2024071800200675000_2024.07.10.602985v1.2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/1574887115999201103200248","article-title":"Efficacy and Safety of EGFR Inhibitors in the Treatment of EGFRPositive NSCLC Patients: A Meta-Analysis","volume":"16","year":"2021","journal-title":"Rev Recent Clin Trials"},{"key":"2024071800200675000_2024.07.10.602985v1.3","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2103695"},{"key":"2024071800200675000_2024.07.10.602985v1.4","doi-asserted-by":"crossref","unstructured":"Man J , Millican J , Mulvey A , Gebski V , and Hui R . 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