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We sought to investigate the application of deep learning methods to electroencephalogram (EEG) signals to predict clinical remission after 6 weeks of home-based transcranial direct current stimulation (tDCS) treatment. Pre-treatment resting-state EEG acquired from 21 bipolar participants was used for this work. A hybrid 1DCNN and GRU model, with input from power spectral density values of theta, beta and gamma frequency bands of the AF7 and TP10 electrodes, achieved a treatment remission prediction accuracy of 78.5% (sensitivity 81.4%, specificity 74.64%).<\/jats:p>","DOI":"10.1101\/2024.07.16.24310445","type":"posted-content","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T03:00:12Z","timestamp":1721185212000},"source":"Crossref","is-referenced-by-count":0,"title":["Deep learning based treatment remission prediction to transcranial direct current stimulation in bipolar depression using EEG power spectral density"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5628-7827","authenticated-orcid":false,"given":"Jijomon","family":"Chettuthara Moncy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel D.","family":"Woodham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali-Reza","family":"Ghazi-Noori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakimeh","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira","family":"Bramon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2291-6952","authenticated-orcid":false,"given":"Allan H.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-4685","authenticated-orcid":false,"given":"Yong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4313-3500","authenticated-orcid":false,"given":"Cynthia H.Y.","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025073118001164000_2024.07.16.24310445v2.1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association, Diagnostic and statistical manual of mental disorders, 5th ed. 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