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It is still unknown how ARBD caused during a critical developmental timepoint, such as adolescence, interacts with AD-related pathologies to accelerate disease progression later in life. The current study utilized a longitudinal design to characterize behavioral and pathological changes in a transgenic rat model of AD (TgF344-AD) following adolescent intermittent ethanol (AIE) exposure. We found that AIE accelerates cognitive decline associated with AD transgenes in female rats at 6 months of age, and male AD-rats are impaired on spatial navigation by 3-months with no additional deficits due to AIE exposure. Protein levels of various AD-pathological markers were analyzed in the dorsal and ventral hippocampus of male and female rats. The data suggests that AIE-induced alterations of the tropomyosin-related kinase A receptor (TrkA) \/ p75 neurotrophin receptor (p75NTR) ratio creates a brain that is vulnerable to age- and AD-related pathologies, which leads to an acceleration of cognitive decline, particularly in female rats.<\/jats:p>","DOI":"10.1101\/2024.07.17.603911","type":"posted-content","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T15:10:22Z","timestamp":1721661022000},"source":"Crossref","is-referenced-by-count":2,"title":["Adolescent alcohol exposure alters age-related progression of behavioral and neurotrophic dysfunction in the TgF344-AD model in a sex-specific manner"],"prefix":"10.64898","author":[{"given":"Nicole L.","family":"Reitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polliana T.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024072408351064000_2024.07.17.603911v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.183"},{"key":"2024072408351064000_2024.07.17.603911v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.06.017"},{"key":"2024072408351064000_2024.07.17.603911v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.45"},{"key":"2024072408351064000_2024.07.17.603911v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.03.004"},{"key":"2024072408351064000_2024.07.17.603911v1.5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.884170"},{"key":"2024072408351064000_2024.07.17.603911v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34368-w"},{"key":"2024072408351064000_2024.07.17.603911v1.7","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.2001.4040"},{"key":"2024072408351064000_2024.07.17.603911v1.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02815225"},{"key":"2024072408351064000_2024.07.17.603911v1.9","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy442"},{"key":"2024072408351064000_2024.07.17.603911v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(01)00324-4"},{"key":"2024072408351064000_2024.07.17.603911v1.11","doi-asserted-by":"publisher","DOI":"10.7150\/thno.56059"},{"key":"2024072408351064000_2024.07.17.603911v1.12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173215"},{"key":"2024072408351064000_2024.07.17.603911v1.13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3672-12.2013"},{"key":"2024072408351064000_2024.07.17.603911v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2021.08.001"},{"key":"2024072408351064000_2024.07.17.603911v1.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01385.x"},{"key":"2024072408351064000_2024.07.17.603911v1.16","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9358-8_7"},{"key":"2024072408351064000_2024.07.17.603911v1.17","doi-asserted-by":"crossref","unstructured":"Cnops V , Iyer VR , Parathy N , Wong P , Dawe GS . 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