{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:02:16Z","timestamp":1790928136409,"version":"4.1.0"},"posted":{"date-parts":[[2024,7,26]]},"group-title":"Neuroscience","reference-count":35,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Women show resilience to cognitive aging, in the absence of dementia, in many populations. To dissect sex differences, we utilized the FCG and XY\n                  <jats:sup>*<\/jats:sup>\n                  mouse models. Female gonads and sex chromosomes improved cognition in aging mice of both sexes. Further, presence of a second X in male and female mice conferred cognitive resilience while its absence in females blocked it. In the hippocampal proteome of aging female mice, the second X increased proteins involved in synaptogenesis signaling \u2013 a potential pathway to improved cognition.\n                <\/jats:p>","DOI":"10.1101\/2024.07.26.605328","type":"posted-content","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T18:10:16Z","timestamp":1722017416000},"source":"Crossref","is-referenced-by-count":5,"title":["A second X chromosome improves cognition in aging male and female mice"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7899-4282","authenticated-orcid":false,"given":"Francesca","family":"Marino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4903-0318","authenticated-orcid":false,"given":"Gennifer E.","family":"Merrihew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1853-0256","authenticated-orcid":false,"given":"Michael J.","family":"MacCoss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7504-4372","authenticated-orcid":false,"given":"Dena B.","family":"Dubal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024073008050548000_2024.07.26.605328v1.1","unstructured":"United Nations DoEaSA, Population Division. World Population Ageing, (2020)."},{"key":"2024073008050548000_2024.07.26.605328v1.2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1701535115"},{"key":"2024073008050548000_2024.07.26.605328v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.01.007"},{"key":"2024073008050548000_2024.07.26.605328v1.4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4821"},{"key":"2024073008050548000_2024.07.26.605328v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64123-6.00018-7"},{"key":"2024073008050548000_2024.07.26.605328v1.6","doi-asserted-by":"publisher","DOI":"10.1037\/pag0000070"},{"key":"2024073008050548000_2024.07.26.605328v1.7","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.0169"},{"key":"2024073008050548000_2024.07.26.605328v1.8","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010046532657"},{"key":"2024073008050548000_2024.07.26.605328v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.01.021"},{"key":"2024073008050548000_2024.07.26.605328v1.10","doi-asserted-by":"publisher","DOI":"10.1159\/000133152"},{"key":"2024073008050548000_2024.07.26.605328v1.11","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-016-0115-5"},{"key":"2024073008050548000_2024.07.26.605328v1.12","doi-asserted-by":"publisher","DOI":"10.1159\/000014954"},{"key":"2024073008050548000_2024.07.26.605328v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.03.076"},{"key":"2024073008050548000_2024.07.26.605328v1.14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5791-12.2015"},{"key":"2024073008050548000_2024.07.26.605328v1.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.07.024"},{"key":"2024073008050548000_2024.07.26.605328v1.16","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00468-0"},{"key":"2024073008050548000_2024.07.26.605328v1.17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2458-21.2022"},{"key":"2024073008050548000_2024.07.26.605328v1.18","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8994-2_10"},{"key":"2024073008050548000_2024.07.26.605328v1.19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-20-09005.2002"},{"key":"2024073008050548000_2024.07.26.605328v1.20","doi-asserted-by":"publisher","DOI":"10.1101\/2023.12.04.569933"},{"key":"2024073008050548000_2024.07.26.605328v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.09.021"},{"key":"2024073008050548000_2024.07.26.605328v1.22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg739"},{"key":"2024073008050548000_2024.07.26.605328v1.23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000112"},{"key":"2024073008050548000_2024.07.26.605328v1.24","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12010"},{"key":"2024073008050548000_2024.07.26.605328v1.25","doi-asserted-by":"publisher","DOI":"10.1038\/srep34220"},{"key":"2024073008050548000_2024.07.26.605328v1.26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100076"},{"key":"2024073008050548000_2024.07.26.605328v1.27","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91352-F"},{"key":"2024073008050548000_2024.07.26.605328v1.28","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq054"},{"key":"2024073008050548000_2024.07.26.605328v1.29","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu305"},{"key":"2024073008050548000_2024.07.26.605328v1.30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00981"},{"key":"2024073008050548000_2024.07.26.605328v1.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-19120-0"},{"key":"2024073008050548000_2024.07.26.605328v1.32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030161"},{"key":"2024073008050548000_2024.07.26.605328v1.33","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"2024073008050548000_2024.07.26.605328v1.34","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1027"},{"key":"2024073008050548000_2024.07.26.605328v1.35","doi-asserted-by":"publisher","DOI":"10.1021\/pr5006636"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2024.07.26.605328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:46:42Z","timestamp":1768459602000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2024.07.26.605328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":35,"URL":"https:\/\/doi.org\/10.1101\/2024.07.26.605328","relation":{},"subject":[],"published":{"date-parts":[[2024,7,26]]},"subtype":"preprint"}}