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While peripheral hearing loss is well understood, central hearing loss\u2014 age-related changes in the central auditory pathways resulting in a listener\u2019s inability to process sound correctly \u2014remains poorly understood. In this study, we focus on the pathway from the cochlear nucleus to the medial nucleus of the trapezoid body (MNTB), which depends on heavily myelinated axons for microsecond-level temporal precision required for sound localization.<\/jats:p>\n                <jats:p>Using a combination of auditory brainstem response recordings (ABR), advanced light and electron microscopy, and behavioral testing with prepulse inhibition of the acoustic startle response (PPI) we identified a correlation between oligodendrocyte loss, abnormal myelination in MNTB afferents, altered ABR wave III morphology indicating MNTB dysfunction, and deficits in spatial hearing behaviors in aging Mongolian gerbils.<\/jats:p>\n                <jats:p>These findings provide a mechanistic explanation of how demyelination contributes to age-related dysfunction in the auditory brainstem\u2019s sound localization 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