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However, under starvation, wasting, or cachexia, the body can eventually catabolize these stable adipocytes through unknown mechanisms. To study this, we developed a mouse model of brain-evoked depletion of all fat, including cBMAT, independent of food intake. Genetic, surgical, and chemical approaches demonstrated that depletion of stable fat required adipose triglyceride lipase-dependent lipolysis but was independent of local nerves, the sympathetic nervous system, and catecholamines. Instead, concurrent hypoglycemia and hypoinsulinemia activated a potent catabolic state by suppressing lipid storage and increasing catecholamine-independent lipolysis via downregulation of cell-autonomous lipolytic inhibitors\n                  <jats:italic>Acvr1c, G0s2, and Npr3<\/jats:italic>\n                  . This was also sufficient to delipidate classical adipose depots. Overall, this work defines unique adaptations of stable adipocytes to resist lipolysis in healthy states while isolating a potent\n                  <jats:italic>in vivo<\/jats:italic>\n                  neurosystemic pathway by which the body can rapidly catabolize all adipose tissues.\n                <\/jats:p>","DOI":"10.1101\/2024.07.30.605812","type":"posted-content","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T13:50:32Z","timestamp":1722433832000},"source":"Crossref","is-referenced-by-count":1,"title":["Central activation of catecholamine-independent lipolysis drives the end-stage catabolism of all adipose tissues"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-0147","authenticated-orcid":false,"given":"Xiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurag","family":"Majumdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3196-1803","authenticated-orcid":false,"given":"Brian","family":"Kleiboeker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristann L","family":"Magee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian S","family":"Learman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-9862","authenticated-orcid":false,"given":"Irfan J","family":"Lodhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6907-7960","authenticated-orcid":false,"given":"Ormond A","family":"MacDougald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-3816","authenticated-orcid":false,"given":"Erica L","family":"Scheller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024080421150436000_2024.07.30.605812v1.1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.plefa.2005.04.010","article-title":"The adipose organ. 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