{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:48:57Z","timestamp":1788320937542,"version":"build-2803163510"},"posted":{"date-parts":[[2024,8,7]]},"group-title":"Immunology","reference-count":61,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Outbreaks of\n                  <jats:italic>Bordetella pertussis<\/jats:italic>\n                  (BP), the causative agent of whooping cough, continue despite broad vaccination coverage and have been increasing since vaccination switched from whole-BP (wP) to acellular BP (aP) vaccines. wP vaccination has been associated with more durable protective immunity and an induced Th1 polarized memory T cell response. Here, a multi-omics approach was applied to profile the immune response of 30 wP and 31 aP-primed individuals and identify correlates of T cell polarization before and after Tdap booster vaccination. We found that transcriptional changes indicating an interferon response on day 1 post-booster along with elevated plasma concentrations of IFN-\u03b3 and interferon-induced chemokines that peaked at day 1-3 post-booster correlated best with the Th1 polarization of the vaccine-induced memory T cell response on day 28. Our studies suggest that wP-primed individuals maintain their Th1 polarization through this early memory interferon response. This suggests that stimulating the interferon pathway during vaccination could be an effective strategy to elicit a predominant Th1 response in aP-primed individuals that protects better against infection.\n                <\/jats:p>","DOI":"10.1101\/2024.08.05.606623","type":"posted-content","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:55:14Z","timestamp":1723060514000},"source":"Crossref","is-referenced-by-count":1,"title":["Th1 polarization in\n                  <i>Bordetella pertussis<\/i>\n                  vaccine responses is maintained through a positive feedback loop"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9676-9249","authenticated-orcid":false,"given":"Lisa","family":"Willemsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1071-2744","authenticated-orcid":false,"given":"Pramod","family":"Shinde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Soldevila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minori","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Orfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-5272","authenticated-orcid":false,"given":"Ricardo","family":"da Silva Antunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8457-6693","authenticated-orcid":false,"given":"Bjoern","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024102102400660000_2024.08.05.606623v2.1","doi-asserted-by":"crossref","unstructured":"Noble BA , Jiudice SS , Jones JD , Timbrook TT . Reemergence of Bordetella parapertussis, United States, 2019-2023. Emerg Infect Dis. 2024;30(5):1058-60.","DOI":"10.3201\/eid3005.231278"},{"key":"2024102102400660000_2024.08.05.606623v2.2","doi-asserted-by":"crossref","unstructured":"Smout E , Mellon D , Rae M . Whooping cough rises sharply in UK and Europe. BMJ. 2024;385:q736.","DOI":"10.1136\/bmj.q736"},{"issue":"12","key":"2024102102400660000_2024.08.05.606623v2.3","first-page":"S310-S20","article-title":"Pertussis (Whooping Cough)","volume":"224","year":"2021","journal-title":"J Infect Dis"},{"key":"2024102102400660000_2024.08.05.606623v2.4","unstructured":"(CDC) CfDCaP. Whooping Cough (Pertussis) Vaccination 2022 [updated September 6, 2022. 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