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However, the ability of CD4\n                  <jats:sup>+<\/jats:sup>\n                  T cells to suppress\n                  <jats:italic>Mtb<\/jats:italic>\n                  growth cannot be fully explained by IFN-\u03b3 or other known T cell products. In this study, we show that CD4\n                  <jats:sup>+<\/jats:sup>\n                  T cell-derived IFN-\u03b3 promoted the recruitment of monocyte-derived macrophages (MDMs) to the lungs of\n                  <jats:italic>Mtb<\/jats:italic>\n                  -infected mice. Although the recruited MDMs became quickly and preferentially infected with\n                  <jats:italic>Mtb<\/jats:italic>\n                  , CD4\n                  <jats:sup>+<\/jats:sup>\n                  T cells rapidly disinfected the MDMs. Clearance of\n                  <jats:italic>Mtb<\/jats:italic>\n                  from MDMs was not explained by IFN-\u03b3, but rather by MHCII-mediated cognate interactions with CD4\n                  <jats:sup>+<\/jats:sup>\n                  T cells. These interactions promoted MDM expression of glycolysis genes essential for\n                  <jats:italic>Mtb<\/jats:italic>\n                  control. Thus, by recruiting MDMs, CD4\n                  <jats:sup>+<\/jats:sup>\n                  T cells initiate a cycle of bacterial phagocytosis,\n                  <jats:italic>Mtb<\/jats:italic>\n                  antigen presentation and disinfection in an attempt to clear the bacteria from the lungs.\n                <\/jats:p>","DOI":"10.1101\/2024.08.22.609198","type":"posted-content","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T15:05:32Z","timestamp":1724425532000},"source":"Crossref","is-referenced-by-count":3,"title":["CD4\n                  <sup>+<\/sup>\n                  T cells recruit, then engage macrophages in cognate interactions to clear\n                  <i>Mycobacterium tuberculosis<\/i>\n                  from the lungs"],"prefix":"10.64898","author":[{"given":"Samuel H","family":"Becker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine E","family":"Ronayne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-6546","authenticated-orcid":false,"given":"Tyler D","family":"Bold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc K","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"issue":"1","key":"2024082709450663000_2024.08.22.609198v1.1","doi-asserted-by":"crossref","first-page":"16076","DOI":"10.1038\/nrdp.2016.76","article-title":"Tuberculosis","volume":"2","year":"2016","journal-title":"Nature Reviews Disease Primers"},{"key":"2024082709450663000_2024.08.22.609198v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2014.09.008"},{"key":"2024082709450663000_2024.08.22.609198v1.3","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832d3b6d"},{"key":"2024082709450663000_2024.08.22.609198v1.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106063242307"},{"issue":"9","key":"2024082709450663000_2024.08.22.609198v1.5","first-page":"5407","article-title":"Mice Deficient in CD4 T Cells Have Only Transiently Diminished Levels of IFN-\u03b3","volume":"162","year":"1999","journal-title":"Yet Succumb to Tuberculosis. 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