{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:02:05Z","timestamp":1768568525960,"version":"3.49.0"},"posted":{"date-parts":[[2024,9,3]]},"group-title":"Neurology","reference-count":60,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>\n                    Autosomal Dominant Alzheimer\u2019s Disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (\n                    <jats:italic>PSEN1)<\/jats:italic>\n                    E280A carriers\u2019 mutation has allowed us to observe incipient tau tangles accumulation as early as 6 years prior to symptom onset.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>\n                    Resting-state functional Magnetic Resonance Imaging (fMRI) and Positron-Emission Tomography (PET) scans were acquired in a group of\n                    <jats:italic>PSEN1<\/jats:italic>\n                    carriers (n=32) and non-carrier family members (n=35). We applied Connectome-based Predictive Modeling (CPM) to examine the relationship between the participant\u2019s functional connectome and their respective tau\/amyloid-\u03b2 levels and cognitive scores (word list recall).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>CPM models strongly predicted tau concentrations and cognitive scores within the carrier group. The connectivity patterns between the temporal cortex, default mode network, and other memory networks were the most informative of tau burden.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>These results indicate that resting-state fMRI methods can complement PET methods in early detection and monitoring of disease progression in ADAD.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2024.09.01.24312913","type":"posted-content","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T13:40:45Z","timestamp":1725370845000},"source":"Crossref","is-referenced-by-count":1,"title":["Connectome-based predictive modeling of brain pathology and cognition in Autosomal Dominant Alzheimer\u2019s Disease"],"prefix":"10.64898","author":[{"given":"Vaibhav","family":"Tripathi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Fox-Fuller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Malotaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Baena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikole Bonillas","family":"Felix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Aguillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Lopera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C","family":"Somers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakeel T.","family":"Quiroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"issue":"2","key":"2024090500401022000_2024.09.01.24312913v1.1","first-page":"112","volume":"6","year":"2020","journal-title":"Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer\u2019s Disease: A Comprehensive Review of the Colombian Kindred"},{"issue":"8","key":"2024090500401022000_2024.09.01.24312913v1.2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1001\/jamaneurol.2015.1099","article-title":"Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study","volume":"72","year":"2015","journal-title":"JAMA Neurol"},{"key":"2024090500401022000_2024.09.01.24312913v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70323-9"},{"issue":"5","key":"2024090500401022000_2024.09.01.24312913v1.4","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jamaneurol.2017.4907","article-title":"Association between amyloid and tau accumulation in young adults with autosomal dominant Alzheimer disease","volume":"75","year":"2018","journal-title":"JAMA Neurol"},{"issue":"1","key":"2024090500401022000_2024.09.01.24312913v1.5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13195-020-00765-5","article-title":"Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer\u2019s disease: findings from the Colombia-Boston (COLBOS) biomarker study","volume":"13","year":"2021","journal-title":"Alzheimers Res. 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