{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:03:39Z","timestamp":1792249419378,"version":"4.4.0"},"posted":{"date-parts":[[2024,9,5]]},"group-title":"Neuroscience","reference-count":49,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Retinal degenerative diseases of photoreceptors are a leading cause of blindness with no effective treatment. Retinal prostheses aim to restore sight by stimulating residual retinal cells. Here, we present a photoacoustic retinal stimulation technology. We designed a polydimethylsiloxane and carbon-based flexible film that converts near-infrared laser pulses into a localized acoustic field with 56-\u00b5m lateral resolution, allowing precise stimulation of mechanosensitive retinal cells. This photoacoustic stimulation robustly and locally modulated retinal ganglion cell activity in both wild-type and degenerated\n                  <jats:italic>ex vivo<\/jats:italic>\n                  rat retinae. In animals subretinally implanted with a millimeter-sized photoacoustic film, pulsed laser stimulation generated neural modulation along the visual pathway to the superior colliculus, as measured by functional ultrasound imaging. The biosafety of the film was confirmed by the absence of short-term adverse effects , while local thermal increases were measured below 1 \u00b0C. These findings demonstrate the potential of photoacoustic stimulation for high-acuity visual restoration in blind patients.\n                <\/jats:p>","DOI":"10.1101\/2024.09.03.611068","type":"posted-content","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T20:00:29Z","timestamp":1725566429000},"source":"Crossref","is-referenced-by-count":4,"title":["A flexible photoacoustic retinal prosthesis"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8340-5524","authenticated-orcid":false,"given":"Audrey","family":"Leong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-0722","authenticated-orcid":false,"given":"Yueming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9886-0011","authenticated-orcid":false,"given":"Thijs R.","family":"Ruikes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Voillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-0127","authenticated-orcid":false,"given":"Yuhao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0239-0068","authenticated-orcid":false,"given":"Guo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Bradic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Facon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-3699","authenticated-orcid":false,"given":"Chakrya-Anna","family":"Chhuon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corentin","family":"Joffrois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3558-925X","authenticated-orcid":false,"given":"Gilles","family":"Tessier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Cornebois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6515-8421","authenticated-orcid":false,"given":"Julie","family":"D\u00e9gardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Damien","family":"Louise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-6683","authenticated-orcid":false,"given":"Ji-Xin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9454-847X","authenticated-orcid":false,"given":"Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Moulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-5145","authenticated-orcid":false,"given":"Serge","family":"Picaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025081723000765000_2024.09.03.611068v3.1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-314422"},{"key":"2025081723000765000_2024.09.03.611068v3.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.06.049"},{"key":"2025081723000765000_2024.09.03.611068v3.3","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.3390\/s23135782","article-title":"Retinal Prostheses: Engineering and Clinical Perspectives for Vision Restoration","volume":"23","year":"2023","journal-title":"Sensors"},{"key":"2025081723000765000_2024.09.03.611068v3.4","doi-asserted-by":"crossref","unstructured":"Muqit, M. 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