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We compared the robustness of a neural circuit to changes in their intrinsic versus synaptic conductances. To address this, we performed a sensitivity analysis on a population of conductance-based models of the pyloric network from the crustacean stomatogastric ganglion (STG). The model network consists of three neurons with nine currents: a sodium current (Na), three potassium currents (Kd, KCa, A-type), two calcium currents (CaS and CaT), a hyperpolarization-activated current (H), a non-voltage-gated leak current (leak), and a neuromodulatory current (MI). The model cells are connected by seven synapses of two types, glutamatergic and cholinergic. We produced one hundred models of the pyloric network that displayed similar activities with values of maximal conductances distributed over wide ranges. We evaluated the robustness of each model to changes in their maximal conductances. We found that individual models have different sensitivities to changes in their maximal conductances, both in their intrinsic and synaptic conductances. As expected the models become less robust as the extent of the changes increase. Despite quantitative differences in their robustness, we found that in all cases, the model networks are more sensitive to the perturbation of their intrinsic conductances than their synaptic conductances.<\/jats:p>","DOI":"10.1101\/2024.09.03.611139","type":"posted-content","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T19:05:15Z","timestamp":1725563115000},"source":"Crossref","is-referenced-by-count":0,"title":["Rhythmic circuit function is more robust to changes in synaptic than intrinsic conductances"],"prefix":"10.64898","author":[{"given":"Zachary","family":"Fournier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-2855","authenticated-orcid":false,"given":"Leandro M.","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9632-5448","authenticated-orcid":false,"given":"Eve","family":"Marder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025020711151142000_2024.09.03.611139v2.1","doi-asserted-by":"publisher","DOI":"10.1038\/81453"},{"key":"2025020711151142000_2024.09.03.611139v2.2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42722"},{"key":"2025020711151142000_2024.09.03.611139v2.3","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55470"},{"key":"2025020711151142000_2024.09.03.611139v2.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.04.027"},{"key":"2025020711151142000_2024.09.03.611139v2.5","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011992"},{"key":"2025020711151142000_2024.09.03.611139v2.6","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201100185"},{"key":"2025020711151142000_2024.09.03.611139v2.7","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00004.2006"},{"key":"2025020711151142000_2024.09.03.611139v2.8","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.67.2.332"},{"key":"2025020711151142000_2024.09.03.611139v2.9","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90007-U"},{"key":"2025020711151142000_2024.09.03.611139v2.10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.31.060407.125639"},{"key":"2025020711151142000_2024.09.03.611139v2.11","doi-asserted-by":"crossref","unstructured":"Crasto, C. 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