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Using\n                  <jats:italic>in vivo<\/jats:italic>\n                  diffusion MRI and data-driven connectivity, we identify a topographic organization between the ZI and neocortex. Specifically, our methods identify a rostral-caudal gradient predominantly connecting the frontopolar and ventral prefrontal cortices with the rostral ZI, and the primary sensorimotor cortices with the caudal ZI. Moreover, we demonstrate how clustering and gradient approaches build complementary evidence including facilitating the mapping of a central region of the ZI, connected with the dorsal prefrontal cortex. These results were shown to be replicable across multiple datasets and at the individual subject level, building evidence for the important role of the ZI in mediating frontal lobe-associated tasks, ranging from motor to cognitive to emotional control. Finally, we consider the impact of this topographic organization on the refinement of neuromodulatory targets. These results pave the way for an increasingly detailed understanding of ZI substructures, and considerations for\n                  <jats:italic>in vivo<\/jats:italic>\n                  targeting of the ZI for neuromodulation.\n                <\/jats:p>","DOI":"10.1101\/2024.09.05.610266","type":"posted-content","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T14:40:21Z","timestamp":1725979221000},"source":"Crossref","is-referenced-by-count":1,"title":["Mapping the topographic organization of the human zona incerta using diffusion MRI"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8543-2467","authenticated-orcid":false,"given":"Roy AM","family":"Haast","sequence":"first","affiliation":[{"name":"Robarts Research Institute, Western University, London, Ontario Canada"},{"name":"Aix Marseille Univ, CNRS, CRMBM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, CEMEREM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7074-6348","authenticated-orcid":false,"given":"Jason","family":"Kai","sequence":"additional","affiliation":[{"name":"Robarts Research Institute, Western University, London, Ontario Canada"},{"name":"Department of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Taha","sequence":"additional","affiliation":[{"name":"Robarts Research Institute, Western University, London, Ontario Canada"},{"name":"School of Biomedical Engineering, Western University, London, Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violet","family":"Liu","sequence":"additional","affiliation":[{"name":"Robarts Research Institute, Western University, London, Ontario Canada"},{"name":"Graduate Program in Neuroscience, Western University, London, 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