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PCs are classically seen as stereotypical computational units, yet mouse PCs are morphologically diverse and those with multi-branched structure can receive non-canonical climbing fiber (CF) multi-innervation that confers independent compartment-specific signaling. While otherwise uncharacterized, human PCs are universally multi-branched. Do they exceed allometry to achieve enhanced integrative capacities relative to mouse PCs? To answer this, we used several comparative histology techniques in adult human and mouse to analyze cellular morphology, parallel fiber (PF) and CF input arrangement, and regional PC demographics. Human PCs are substantially larger than previously described; they exceed allometric constraint by cortical thickness and are the largest neuron in the brain with 6-7cm total dendritic length. Unlike mouse, human PC dendrites ramify horizontally to form a multi-compartment motif that we show can receive multiple CFs. Human spines are denser (6.9 vs 4.9 spines\/\u03bcm), larger (\u223c0.36 vs 0.29\u03bcm), and include an unreported \u2018spine cluster\u2019 structure\u2014features that may be congruent with enhanced PF association and amplification as human-specific adaptations. By extrapolation, human PCs may receive 500,000 to 1 million synaptic inputs compared with 30-40,000 in mouse. Collectively, human PC morphology and input arrangement is quantitatively and qualitatively distinct from rodent. Multi-branched PCs are more prevalent in posterior and lateral cerebellum, co-varying with functional boundaries, supporting the hypothesis that this morphological motif permits expanded input multiplexing and may subserve task-dependent needs for input association.<\/jats:p>","DOI":"10.1101\/2024.09.09.612113","type":"posted-content","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T04:55:22Z","timestamp":1725944122000},"source":"Crossref","is-referenced-by-count":0,"title":["Non-allometric expansion and enhanced compartmentalization of Purkinje cell dendrites in the human cerebellum"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-1921","authenticated-orcid":false,"given":"Silas E.","family":"Busch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hansel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025022214200516000_2024.09.09.612113v3.1","doi-asserted-by":"publisher","DOI":"10.1016\/0025-5564(71)90051-4"},{"key":"2025022214200516000_2024.09.09.612113v3.2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008820"},{"key":"2025022214200516000_2024.09.09.612113v3.3","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90380-9"},{"key":"2025022214200516000_2024.09.09.612113v3.4","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi1024"},{"key":"2025022214200516000_2024.09.09.612113v3.5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016163"},{"key":"2025022214200516000_2024.09.09.612113v3.6","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24206"},{"key":"2025022214200516000_2024.09.09.612113v3.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.011"},{"key":"2025022214200516000_2024.09.09.612113v3.8","first-page":"23","article-title":"Spatial synaptic integration in Purkinje cell dendrites","volume":"89","year":"1995","journal-title":"The Journal of Physiology"},{"key":"2025022214200516000_2024.09.09.612113v3.9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3211-18.2019"},{"key":"2025022214200516000_2024.09.09.612113v3.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.05.025"},{"key":"2025022214200516000_2024.09.09.612113v3.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07233-7"},{"key":"2025022214200516000_2024.09.09.612113v3.12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1719-20.2020"},{"key":"2025022214200516000_2024.09.09.612113v3.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110756"},{"key":"2025022214200516000_2024.09.09.612113v3.14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48373-3"},{"key":"2025022214200516000_2024.09.09.612113v3.15","unstructured":"Golgi, C. 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