{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:36:42Z","timestamp":1790185002830,"version":"4.1.0"},"posted":{"date-parts":[[2024,9,16]]},"group-title":"Developmental Biology","reference-count":27,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Normal placental development and angiogenesis are crucial for fetal growth and maternal health during pregnancy. However, molecular regulation of placental angiogenesis has been difficult to study due to a lack of specific genetic tools that isolate the placenta from the embryo and yolk sac. To address this gap in knowledge we recently developed\n                  <jats:italic>Hoxa13<\/jats:italic>\n                  <jats:sup>\n                    <jats:italic>Cre<\/jats:italic>\n                  <\/jats:sup>\n                  mice in which Cre is expressed in allantois-derived cells, including placental endothelial and stromal cells. Mice lacking the transcriptional regulators Yes-associated protein (YAP) and PDZ-binding motif (TAZ) in allantois-derived cells exhibit embryonic lethality at midgestation with compromised placental vasculature. snRNA-seq analysis revealed transcriptional changes in placental stromal cells and endothelial cells. YAP\/TAZ mutants exhibited significantly reduced placental stromal cells prior to the endothelial architectural change, highlighting the role of these cells in placental vascular growth. These results reveal a central role for YAP\/TAZ signaling during placental vascular growth and implicate\n                  <jats:italic>Hoxa13<\/jats:italic>\n                  -derived placental stromal cells as a critical component of placental vascularization.\n                <\/jats:p>","DOI":"10.1101\/2024.09.15.613151","type":"posted-content","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T12:05:16Z","timestamp":1726488316000},"source":"Crossref","is-referenced-by-count":2,"title":["YAP\/TAZ signaling in allantois-derived cells is required for placental vascularization"],"prefix":"10.64898","author":[{"given":"Siqi","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Triloshan","family":"Thillaikumaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin 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