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There are no approved treatments for CC, which may relate to discordance between pre-clinical models and human CC. To address the need for clinically relevant models of lung CC, we generated inducible, lung epithelial cell specific\n                  <jats:italic>\n                    Kras\n                    <jats:sup>G12D\/+<\/jats:sup>\n                  <\/jats:italic>\n                  (\n                  <jats:italic>G12D<\/jats:italic>\n                  ) mice.\n                  <jats:italic>G12D<\/jats:italic>\n                  mice develop CC over a protracted time course and phenocopy tissue and tumor, cellular, mutational, transcriptomic, and metabolic characteristics of human lung CC.\n                  <jats:italic>G12D<\/jats:italic>\n                  mice demonstrate early loss of adipose, a phenotype that was apparent across numerous models of CC and translates to patients with lung cancer. Tumor-released factors promote adipocyte lipolysis, a driver of adipose wasting in CC, and adipose wasting was inversely related to tumor burden. Thus,\n                  <jats:italic>G12D<\/jats:italic>\n                  mice model key features of human lung CC and highlight a role for early tumor metabolic reprogramming of adipose tissue in CC.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Graphical Abstract<\/jats:title>\n                  <jats:fig id=\"ufig1\" position=\"float\" orientation=\"portrait\" fig-type=\"figure\">\n                    <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"615385v3_ufig1\" position=\"float\" orientation=\"portrait\"\/>\n                  <\/jats:fig>\n                <\/jats:sec>","DOI":"10.1101\/2024.09.27.615385","type":"posted-content","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T08:25:13Z","timestamp":1727684713000},"source":"Crossref","is-referenced-by-count":1,"title":["Early adipose tissue wasting in a novel preclinical model of human lung cancer cachexia"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-9441","authenticated-orcid":false,"given":"Deena B.","family":"Snoke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2451-3180","authenticated-orcid":false,"given":"Jos L.","family":"van der Velden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma R.","family":"Bellafleur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-1574","authenticated-orcid":false,"given":"Jacob S.","family":"Dearborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3222-970X","authenticated-orcid":false,"given":"Sean M.","family":"Lenahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra E.","family":"Beal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Aboushousha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skyler C. 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