{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T17:28:18Z","timestamp":1770571698818,"version":"3.49.0"},"posted":{"date-parts":[[2024,10,7]]},"group-title":"Neuroscience","reference-count":110,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,11,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>Understanding the neurophysiological changes that occur during loss and recovery of consciousness is a fundamental aim in neuroscience and has marked clinical relevance. Here, we utilize multimodal magnetic resonance neuroimaging to investigate changes in regional network connectivity and neurovascular dynamics as the brain transitions from wakefulness to dexmedetomidine-induced unconsciousness, and finally into early-stage recovery of consciousness. We observed widespread decreases in functional connectivity strength across the whole brain, and targeted increases in structure-function coupling (SFC) across select networks\u2014 especially the cerebellum\u2014as individuals transitioned from wakefulness to hypnosis. We also observed robust decreases in cerebral blood flow (CBF) across the whole brain\u2014especially within the brainstem, thalamus, and cerebellum. Moreover, hypnosis was characterized by significant increases in the amplitude of low-frequency fluctuations (ALFF) of the resting-state blood oxygen level-dependent signal, localized within visual and somatomotor regions. Critically, when transitioning from hypnosis to the early stages of recovery, functional connectivity strength and SFC\u2014but not CBF\u2014started reverting towards their awake levels, even before behavioral arousal. By further testing for a relationship between connectivity and neurovascular alterations, we observed that during wakefulness, brain regions with higher ALFF displayed lower functional connectivity with the rest of the brain. During hypnosis, brain regions with higher ALFF displayed weaker coupling between structural and functional connectivity. Correspondingly, brain regions with stronger functional connectivity strength during wakefulness showed greater reductions in CBF with the onset of hypnosis. Earlier recovery of consciousness was associated with higher baseline (awake) levels of functional connectivity strength, CBF, and ALFF, as well as female sex. Across our findings, we also highlight the role of the cerebellum as a recurrent marker of connectivity and neurovascular changes between states of consciousness. Collectively, these results demonstrate that induction of, and emergence from dexmedetomidine-induced unconsciousness are characterized by widespread changes in connectivity and neurovascular dynamics.<\/jats:p>","DOI":"10.1101\/2024.10.04.616650","type":"posted-content","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:25:15Z","timestamp":1728303915000},"source":"Crossref","is-referenced-by-count":0,"title":["Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7287-9227","authenticated-orcid":false,"given":"Panagiotis","family":"Fotiadis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"McKinstry-Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Cieslak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey T.","family":"Duda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore D.","family":"Satterthwaite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell T.","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Proekt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max B.","family":"Kelz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Detre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani S.","family":"Bassett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024111506301681000_2024.10.04.616650v2.1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0107"},{"key":"2024111506301681000_2024.10.04.616650v2.2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4962-11.2012"},{"key":"2024111506301681000_2024.10.04.616650v2.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1904710"},{"key":"2024111506301681000_2024.10.04.616650v2.4","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.94750"},{"key":"2024111506301681000_2024.10.04.616650v2.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01537.x"},{"key":"2024111506301681000_2024.10.04.616650v2.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.10.005"},{"key":"2024111506301681000_2024.10.04.616650v2.7","doi-asserted-by":"publisher","DOI":"10.1097\/Aln.0000000000003567"},{"key":"2024111506301681000_2024.10.04.616650v2.8","doi-asserted-by":"publisher","DOI":"10.1093\/bjaed\/mkv047"},{"key":"2024111506301681000_2024.10.04.616650v2.9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153200"},{"key":"2024111506301681000_2024.10.04.616650v2.10","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3957"},{"key":"2024111506301681000_2024.10.04.616650v2.11","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.054544"},{"key":"2024111506301681000_2024.10.04.616650v2.12","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04499"},{"key":"2024111506301681000_2024.10.04.616650v2.13","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200302000-00024"},{"key":"2024111506301681000_2024.10.04.616650v2.14","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001509"},{"key":"2024111506301681000_2024.10.04.616650v2.15","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex257"},{"key":"2024111506301681000_2024.10.04.616650v2.16","doi-asserted-by":"crossref","unstructured":"Baller, E. B. et al. Developmental coupling of cerebral blood flow and fMRI fluctuations in youth. Cell Rep. 38, 110576 (2022).","DOI":"10.1016\/j.celrep.2022.110576"},{"key":"2024111506301681000_2024.10.04.616650v2.17","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.8989"},{"key":"2024111506301681000_2024.10.04.616650v2.18","doi-asserted-by":"crossref","unstructured":"Chiacchiaretta, P. , Cerritelli, F. , Bubbico, G. , Perrucci, M. G. & Ferretti, A . Reduced Dynamic Coupling Between Spontaneous BOLD-CBF Fluctuations in Older Adults: A Dual-Echo pCASL Study. Front. Aging Neurosci. 10, 115 (2018).","DOI":"10.3389\/fnagi.2018.00115"},{"key":"2024111506301681000_2024.10.04.616650v2.19","doi-asserted-by":"crossref","unstructured":"Archila-Mel\u00e9ndez, M. E. , Sorg, C. & Preibisch, C . Modeling the impact of neurovascular coupling impairments on BOLD-based functional connectivity at rest. NeuroImage 218, 116871 (2020).","DOI":"10.1016\/j.neuroimage.2020.116871"},{"key":"2024111506301681000_2024.10.04.616650v2.20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163431"},{"key":"2024111506301681000_2024.10.04.616650v2.21","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000419"},{"key":"2024111506301681000_2024.10.04.616650v2.22","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31829103f5"},{"key":"2024111506301681000_2024.10.04.616650v2.23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210907109"},{"key":"2024111506301681000_2024.10.04.616650v2.24","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.3.283"},{"key":"2024111506301681000_2024.10.04.616650v2.25","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000841"},{"key":"2024111506301681000_2024.10.04.616650v2.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2016.03.005"},{"key":"2024111506301681000_2024.10.04.616650v2.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.03.076"},{"key":"2024111506301681000_2024.10.04.616650v2.28","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003668"},{"key":"2024111506301681000_2024.10.04.616650v2.29","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001759"},{"key":"2024111506301681000_2024.10.04.616650v2.30","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax5440"},{"key":"2024111506301681000_2024.10.04.616650v2.31","first-page":"7","article-title":"Large-Scale Brain Dynamics in Disorders of Consciousness","volume":"0","year":"2014","journal-title":"Curr. Opin. Neurobiol"},{"key":"2024111506301681000_2024.10.04.616650v2.32","doi-asserted-by":"crossref","unstructured":"Young, G. B . The EEG in Coma. J. Clin. Neurophysiol. 17, 473 (2000).","DOI":"10.1097\/00004691-200009000-00006"},{"key":"2024111506301681000_2024.10.04.616650v2.33","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1910-19.2019"},{"key":"2024111506301681000_2024.10.04.616650v2.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.05.025"},{"key":"2024111506301681000_2024.10.04.616650v2.35","first-page":"S16","article-title":"Delta Wave Power: An Independent Sleep Phenotype or Epiphenomenon?","volume":"7","year":"2011","journal-title":"J. Clin. Sleep Med. JCSM Off. Publ. Am. Acad. Sleep Med"},{"key":"2024111506301681000_2024.10.04.616650v2.36","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-024-00846-6"},{"key":"2024111506301681000_2024.10.04.616650v2.37","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"2024111506301681000_2024.10.04.616650v2.38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608282113"},{"key":"2024111506301681000_2024.10.04.616650v2.39","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2021.06.016"},{"key":"2024111506301681000_2024.10.04.616650v2.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.02.028"},{"key":"2024111506301681000_2024.10.04.616650v2.41","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15615339"},{"key":"2024111506301681000_2024.10.04.616650v2.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.04.012"},{"key":"2024111506301681000_2024.10.04.616650v2.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41686-9"},{"key":"2024111506301681000_2024.10.04.616650v2.44","doi-asserted-by":"crossref","unstructured":"Demertzi, A. et al. Human consciousness is supported by dynamic complex patterns of brain signal coordination. Sci. Adv. 5, eaat7603 (2019).","DOI":"10.1126\/sciadv.aat7603"},{"key":"2024111506301681000_2024.10.04.616650v2.45","doi-asserted-by":"crossref","unstructured":"Perl, Y. S. et al. Low-dimensional organization of global brain states of reduced consciousness. Cell Rep. 42, 112491 (2023).","DOI":"10.1016\/j.celrep.2023.112491"},{"key":"2024111506301681000_2024.10.04.616650v2.46","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04819-w"},{"key":"2024111506301681000_2024.10.04.616650v2.47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418031112"},{"key":"2024111506301681000_2024.10.04.616650v2.48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46382-w"},{"key":"2024111506301681000_2024.10.04.616650v2.49","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05726-w"},{"key":"2024111506301681000_2024.10.04.616650v2.50","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1162-0"},{"key":"2024111506301681000_2024.10.04.616650v2.51","doi-asserted-by":"crossref","unstructured":"Dolui, S. et al. Reliability of arterial spin labeling derived cerebral blood flow in periventricular white matter. Neuroimage Rep. 1, 100063 (2021).","DOI":"10.1016\/j.ynirp.2021.100063"},{"key":"2024111506301681000_2024.10.04.616650v2.52","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.3.633"},{"key":"2024111506301681000_2024.10.04.616650v2.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.080"},{"key":"2024111506301681000_2024.10.04.616650v2.54","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200210000-00048"},{"key":"2024111506301681000_2024.10.04.616650v2.55","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000299576.00302.4c"},{"key":"2024111506301681000_2024.10.04.616650v2.56","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13571"},{"key":"2024111506301681000_2024.10.04.616650v2.57","doi-asserted-by":"crossref","unstructured":"Mikkelsen, M. L. G. et al. The effect of dexmedetomidine on cerebral perfusion and oxygenation in healthy piglets with normal and lowered blood pressure anaesthetized with propofol-remifentanil total intravenous anaesthesia. Acta Vet. Scand. 59, 27 (2017).","DOI":"10.1186\/s13028-017-0293-0"},{"key":"2024111506301681000_2024.10.04.616650v2.58","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181862a33"},{"key":"2024111506301681000_2024.10.04.616650v2.59","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.115"},{"key":"2024111506301681000_2024.10.04.616650v2.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.03.016"},{"key":"2024111506301681000_2024.10.04.616650v2.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2017.09.004"},{"key":"2024111506301681000_2024.10.04.616650v2.62","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-021-00983-5"},{"key":"2024111506301681000_2024.10.04.616650v2.63","doi-asserted-by":"crossref","unstructured":"Kyrou, A. et al. Test-retest reliability of resting-state cerebral blood flow quantification using pulsed Arterial Spin Labeling (PASL) over 3 weeks vs 8 weeks in healthy controls. Psychiatry Res. Neuroimaging 341, 111823 (2024).","DOI":"10.1016\/j.pscychresns.2024.111823"},{"key":"2024111506301681000_2024.10.04.616650v2.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.09.038"},{"key":"2024111506301681000_2024.10.04.616650v2.65","doi-asserted-by":"crossref","unstructured":"Vedaei, F. , Alizadeh, M. , Romo, V. , Mohamed, F. B. & Wu, C . The effect of general anesthesia on the test\u2013retest reliability of resting-state fMRI metrics and optimization of scan length. Front. Neurosci. 16, (2022).","DOI":"10.3389\/fnins.2022.937172"},{"key":"2024111506301681000_2024.10.04.616650v2.66","doi-asserted-by":"crossref","unstructured":"Wang, P. et al. Amplitude of low-frequency fluctuation (ALFF) may be associated with cognitive impairment in schizophrenia: a correlation study. BMC Psychiatry 19, 30 (2019).","DOI":"10.1186\/s12888-018-1992-4"},{"key":"2024111506301681000_2024.10.04.616650v2.67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2016732119"},{"key":"2024111506301681000_2024.10.04.616650v2.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2006.04.018"},{"key":"2024111506301681000_2024.10.04.616650v2.69","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20428"},{"key":"2024111506301681000_2024.10.04.616650v2.70","doi-asserted-by":"crossref","unstructured":"Bohr, T. et al. The glymphatic system: Current understanding and modeling. iScience 25, 104987 (2022).","DOI":"10.1016\/j.isci.2022.104987"},{"key":"2024111506301681000_2024.10.04.616650v2.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.09.007"},{"key":"2024111506301681000_2024.10.04.616650v2.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.05.005"},{"key":"2024111506301681000_2024.10.04.616650v2.73","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001888"},{"key":"2024111506301681000_2024.10.04.616650v2.74","doi-asserted-by":"crossref","unstructured":"Wang, S. et al. Dexmedetomidine improves the circulatory dysfunction of the glymphatic system induced by sevoflurane through the PI3K\/AKT\/\u0394FosB\/AQP4 pathway in young mice. Cell Death Dis. 15, 448 (2024).","DOI":"10.1038\/s41419-024-06845-w"},{"key":"2024111506301681000_2024.10.04.616650v2.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.12.043"},{"key":"2024111506301681000_2024.10.04.616650v2.76","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-014111"},{"key":"2024111506301681000_2024.10.04.616650v2.77","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.23"},{"key":"2024111506301681000_2024.10.04.616650v2.78","first-page":"210","volume":"22","year":"1936","journal-title":"The Magnetic Properties and Structure of Hemoglobin, Oxyhemoglobin and Carbonmonoxyhemoglobin. Proc. Natl. Acad. Sci"},{"key":"2024111506301681000_2024.10.04.616650v2.79","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18791070"},{"key":"2024111506301681000_2024.10.04.616650v2.80","doi-asserted-by":"crossref","unstructured":"Deng, S. et al. Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults. NeuroImage 250, 118923 (2022).","DOI":"10.1016\/j.neuroimage.2022.118923"},{"key":"2024111506301681000_2024.10.04.616650v2.81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2312913120"},{"key":"2024111506301681000_2024.10.04.616650v2.82","first-page":"e217\u2013e224","volume":"130","year":"2023","journal-title":"Connected consciousness after tracheal intubation in young adults: an international multicentre cohort study. BJA Br. J. Anaesth"},{"key":"2024111506301681000_2024.10.04.616650v2.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2023.06.042"},{"key":"2024111506301681000_2024.10.04.616650v2.84","first-page":"e3619","article-title":"Sex Differences in the Morphine-Sparing Effects of Intraoperative Dexmedetomidine in Patient-Controlled Analgesia Following General Anesthesia: A Consort-Prospective, Randomized","volume":"95","year":"2016","journal-title":"Controlled Clinical Trial. Medicine (Baltimore"},{"key":"2024111506301681000_2024.10.04.616650v2.85","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5062-08.2009"},{"key":"2024111506301681000_2024.10.04.616650v2.86","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu132"},{"key":"2024111506301681000_2024.10.04.616650v2.87","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.025"},{"key":"2024111506301681000_2024.10.04.616650v2.88","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"2024111506301681000_2024.10.04.616650v2.89","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.11.020"},{"key":"2024111506301681000_2024.10.04.616650v2.90","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1256"},{"key":"2024111506301681000_2024.10.04.616650v2.91","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"2024111506301681000_2024.10.04.616650v2.92","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.027"},{"key":"2024111506301681000_2024.10.04.616650v2.93","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"2024111506301681000_2024.10.04.616650v2.94","doi-asserted-by":"crossref","unstructured":"Tournier, J.-D. et al. MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation. NeuroImage 202, 116137 (2019).","DOI":"10.1016\/j.neuroimage.2019.116137"},{"key":"2024111506301681000_2024.10.04.616650v2.95","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.06.092"},{"key":"2024111506301681000_2024.10.04.616650v2.96","unstructured":"Statistical Parametric Mapping: The Analysis of Functional Brain Images. (Elsevier, 2011)."},{"key":"2024111506301681000_2024.10.04.616650v2.97","doi-asserted-by":"crossref","unstructured":"Chen, S. et al. Global Functional Connectivity at Rest Is Associated with Attention: An Arterial Spin Labeling Study. Brain Sci. 13, 228 (2023).","DOI":"10.3390\/brainsci13020228"},{"key":"2024111506301681000_2024.10.04.616650v2.98","doi-asserted-by":"crossref","unstructured":"Mahadevan, A. S. , Tooley, U. A. , Bertolero, M. A. , Mackey, A. P. & Bassett, D. S . Evaluating the sensitivity of functional connectivity measures to motion artifact in resting-state fMRI data. NeuroImage 241, 118408 (2021).","DOI":"10.1016\/j.neuroimage.2021.118408"},{"key":"2024111506301681000_2024.10.04.616650v2.99","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24600"},{"key":"2024111506301681000_2024.10.04.616650v2.100","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"2024111506301681000_2024.10.04.616650v2.101","unstructured":"Nieto-Castanon, A. Handbook of fcMRI Methods in CONN. (Hilbert Press, Boston, MA, 2020)."},{"key":"2024111506301681000_2024.10.04.616650v2.102","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.01.054"},{"key":"2024111506301681000_2024.10.04.616650v2.103","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25197"},{"key":"2024111506301681000_2024.10.04.616650v2.104","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25577"},{"key":"2024111506301681000_2024.10.04.616650v2.105","doi-asserted-by":"publisher","DOI":"10.1111\/insp.12026"},{"key":"2024111506301681000_2024.10.04.616650v2.106","doi-asserted-by":"publisher","DOI":"10.1017\/pan.2018.12"},{"key":"2024111506301681000_2024.10.04.616650v2.107","first-page":"1","article-title":"Quantitative evaluation of gender bias in astronomical publications from citation counts","volume":"1","year":"2017","journal-title":"Nat. Astron"},{"key":"2024111506301681000_2024.10.04.616650v2.108","doi-asserted-by":"publisher","DOI":"10.1017\/S0020818313000209"},{"key":"2024111506301681000_2024.10.04.616650v2.109","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0658-y"},{"key":"2024111506301681000_2024.10.04.616650v2.110","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2024.10.04.616650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:13:14Z","timestamp":1768461194000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2024.10.04.616650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":110,"URL":"https:\/\/doi.org\/10.1101\/2024.10.04.616650","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1038\/s42003-025-08577-9","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2024,10,7]]},"subtype":"preprint"}}