{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:21:01Z","timestamp":1768569661920,"version":"3.49.0"},"posted":{"date-parts":[[2024,10,8]]},"group-title":"Addiction Medicine","reference-count":90,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,10,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study investigated the genetic and epigenetic mechanisms underlying the comorbidity patterns of five substance dependence diagnoses (SDs; alcohol, AD; cannabis, CaD; cocaine, CoD; opioid, OD; tobacco, TD).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A latent class analysis (LCA) was performed on 31,197 individuals (average age 42\u00b111 years; 49% females) from six cohorts to identify comorbid DSM-IV SD patterns. In subsets of this sample, we tested SD-latent classes with respect to polygenic burden of psychiatric and behavioral traits and epigenome-wide changes in three population groups.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    An LCA identified four latent classes related to SD comorbidities: AD+TD, CoD+TD, AD+CoD+OD+TD (i.e., polysubstance use, PSU), and TD. In the epigenome-wide association analysis,\n                    <jats:italic>SPATA4<\/jats:italic>\n                    cg02833127 was associated with CoD+TD, AD+TD, and PSU latent classes. AD+TD latent class was also associated with CpG sites located on\n                    <jats:italic>ARID1B<\/jats:italic>\n                    ,\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    ,\n                    <jats:italic>SERTAD4,<\/jats:italic>\n                    and\n                    <jats:italic>SIN3B<\/jats:italic>\n                    , while additional epigenome-wide significant associations with CoD+TD latent class were observed in\n                    <jats:italic>ANO6<\/jats:italic>\n                    and\n                    <jats:italic>MOV10<\/jats:italic>\n                    genes. PSU-latent class was also associated with a differentially methylated region in\n                    <jats:italic>LDB1<\/jats:italic>\n                    . We also observed shared polygenic score (PGS) associations for PSU, AD+TD, and CoD+TD latent classes (i.e., attention-deficit hyperactivity disorder, anxiety, educational attainment, and schizophrenia PGS). In contrast, TD-latent class was exclusively associated with posttraumatic stress disorder-PGS. Other specific associations were observed for PSU-latent class (subjective wellbeing-PGS and neuroticism-PGS) and AD+TD-latent class (bipolar disorder-PGS).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We identified shared and unique genetic and epigenetic mechanisms underlying SD comorbidity patterns. These findings highlight the importance of modeling the co-occurrence of SD diagnoses when investigating the molecular basis of addiction-related traits.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2024.10.08.24315111","type":"posted-content","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T21:15:17Z","timestamp":1728422117000},"source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3943-0895","authenticated-orcid":false,"given":"Gita A.","family":"Pathak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Pietrzak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AnnMarie","family":"Lacobelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassie","family":"Overstreet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank R.","family":"Wendt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-6080","authenticated-orcid":false,"given":"Joseph D.","family":"Deak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Friligkou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaira","family":"Nunez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janitza L.","family":"Montalvo-Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-9569","authenticated-orcid":false,"given":"Daniel F.","family":"Levey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry R.","family":"Kranzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4067-1859","authenticated-orcid":false,"given":"Joel","family":"Gelernter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0745-6046","authenticated-orcid":false,"given":"Renato","family":"Polimanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024101100201723000_2024.10.08.24315111v1.1","unstructured":"Substance Use & Substance Use Disorders. https:\/\/www.nc.cdc.gov\/travel\/yellowbook\/2024\/additional-considerations\/substance-use, 2024, Accessed Date Accessed 2024 Accessed."},{"key":"2024101100201723000_2024.10.08.24315111v1.2","unstructured":"Abuse NIoD. Common Comorbidities with Substance Use Disorders Research Report. NCBI: Bethesda (MD), 2020."},{"key":"2024101100201723000_2024.10.08.24315111v1.3","unstructured":"Owens PL , Heslin KC , Fingar KR , Weiss AJ . Co-occurrence of Physical Health Conditions and Mental Health and Substance Use Conditions Among Adult Inpatient Stays, 2010 Versus 2014. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs: Rockville (MD), 2006."},{"issue":"2","key":"2024101100201723000_2024.10.08.24315111v1.4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/acer.14528","article-title":"Associations of Alcohol Consumption With Epigenome-Wide DNA Methylation and Epigenetic Age Acceleration: Individual-Level and Co-twin Comparison Analyses","volume":"45","year":"2021","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"2024101100201723000_2024.10.08.24315111v1.5","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1038\/s41598-019-41110-7","article-title":"Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European-American Women","volume":"9","year":"2019","journal-title":"Sci Rep"},{"key":"2024101100201723000_2024.10.08.24315111v1.6","doi-asserted-by":"crossref","first-page":"1075250","DOI":"10.3389\/fpsyt.2023.1075250","article-title":"DNA methylation in cocaine use disorder-An epigenome-wide approach in the human prefrontal cortex","volume":"14","year":"2023","journal-title":"Front Psychiatry"},{"key":"2024101100201723000_2024.10.08.24315111v1.7","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0734-4"},{"issue":"6","key":"2024101100201723000_2024.10.08.24315111v1.8","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.biopsych.2022.08.010","article-title":"Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample","volume":"93","year":"2023","journal-title":"Biol Psychiatry"},{"issue":"13","key":"2024101100201723000_2024.10.08.24315111v1.9","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1017\/S0033291721000969","article-title":"Genetics of substance use disorders: a review","volume":"51","year":"2021","journal-title":"Psychol Med"},{"key":"2024101100201723000_2024.10.08.24315111v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-021-00377-1"},{"key":"2024101100201723000_2024.10.08.24315111v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.145"},{"key":"2024101100201723000_2024.10.08.24315111v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.08.034"},{"key":"2024101100201723000_2024.10.08.24315111v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.08.025"},{"key":"2024101100201723000_2024.10.08.24315111v1.14","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.99"},{"issue":"5","key":"2024101100201723000_2024.10.08.24315111v1.15","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1001\/jamapsychiatry.2016.0036","article-title":"Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks","volume":"73","year":"2016","journal-title":"JAMA Psychiatry"},{"key":"2024101100201723000_2024.10.08.24315111v1.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2012.03922.x"},{"issue":"3","key":"2024101100201723000_2024.10.08.24315111v1.17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1001\/jamapsychiatry.2013.282","article-title":"ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure","volume":"70","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"2024101100201723000_2024.10.08.24315111v1.18","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl441"},{"key":"2024101100201723000_2024.10.08.24315111v1.19","doi-asserted-by":"publisher","DOI":"10.1375\/twin.13.4.359"},{"issue":"10","key":"2024101100201723000_2024.10.08.24315111v1.20","first-page":"1","article-title":"poLCA: An R Package for Polytomous Variable Latent Class Analysis","volume":"42","year":"2011","journal-title":"Journal of Statistical Software"},{"issue":"1","key":"2024101100201723000_2024.10.08.24315111v1.21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/10705511.2011.532732","article-title":"Conducting Confirmatory Latent Class Analysis Using Mplus","volume":"18","year":"2011","journal-title":"Structural Equation Modeling: A Multidisciplinary Journal"},{"issue":"1","key":"2024101100201723000_2024.10.08.24315111v1.22","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40246-023-00487-3","article-title":"Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program","volume":"17","year":"2023","journal-title":"Hum Genomics"},{"key":"2024101100201723000_2024.10.08.24315111v1.23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq559"},{"key":"2024101100201723000_2024.10.08.24315111v1.24","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3656"},{"key":"2024101100201723000_2024.10.08.24315111v1.25","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts680"},{"key":"2024101100201723000_2024.10.08.24315111v1.26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034"},{"key":"2024101100201723000_2024.10.08.24315111v1.27","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-86"},{"key":"2024101100201723000_2024.10.08.24315111v1.28","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2019-0206"},{"key":"2024101100201723000_2024.10.08.24315111v1.29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"2024101100201723000_2024.10.08.24315111v1.30","doi-asserted-by":"crossref","unstructured":"Turner SD . qqman: an R package for visualizing GWAS results using Q-Q and manhattan plots. Journal of Open Source Software 2018; 3.","DOI":"10.21105\/joss.00731"},{"key":"2024101100201723000_2024.10.08.24315111v1.31","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-288"},{"key":"2024101100201723000_2024.10.08.24315111v1.32","doi-asserted-by":"crossref","unstructured":"Suderman M , Staley JR , French R , Arathimos R , Simpkin A , Tilling K. dmrff: identifying differentially methylated regions efficiently with power and control. bioRxiv 2018: 508556.","DOI":"10.1101\/508556"},{"key":"2024101100201723000_2024.10.08.24315111v1.33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.12688\/wellcomeopenres.17598.2","article-title":"The EWAS Catalog: a database of epigenome-wide association studies","volume":"7","year":"2022","journal-title":"Wellcome Open Res"},{"issue":"8","key":"2024101100201723000_2024.10.08.24315111v1.34","doi-asserted-by":"crossref","first-page":"e1187","DOI":"10.1038\/tp.2017.171","article-title":"BECon: a tool for interpreting DNA methylation findings from blood in the context of brain","volume":"7","year":"2017","journal-title":"Translational psychiatry"},{"key":"2024101100201723000_2024.10.08.24315111v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/S41588-022-01285-8"},{"key":"2024101100201723000_2024.10.08.24315111v1.36","doi-asserted-by":"crossref","unstructured":"Friligkou E , L\u00f8khammer S , Cabrera-Mendoza B , Shen J , He J , Deiana G et al. Gene Discovery and Biological Insights into Anxiety Disorders from a Multi-Ancestry Genome-wide Association Study of >1.2 Million Participants. medRxiv 2024: 2024.2002.2014.24302836.","DOI":"10.1101\/2024.02.14.24302836"},{"key":"2024101100201723000_2024.10.08.24315111v1.37","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0344-8"},{"key":"2024101100201723000_2024.10.08.24315111v1.38","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00857-4"},{"key":"2024101100201723000_2024.10.08.24315111v1.39","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02352-1"},{"key":"2024101100201723000_2024.10.08.24315111v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/s41588--01016-z"},{"key":"2024101100201723000_2024.10.08.24315111v1.41","doi-asserted-by":"crossref","first-page":"108692","DOI":"10.1016\/j.biopsycho.2023.108692","article-title":"Genetic and neural bases of the neuroticism general factor","volume":"184","year":"2023","journal-title":"Biol Psychol"},{"issue":"5","key":"2024101100201723000_2024.10.08.24315111v1.42","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41588-024-01707-9","article-title":"Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder","volume":"56","year":"2024","journal-title":"Nat Genet"},{"key":"2024101100201723000_2024.10.08.24315111v1.43","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-022-04434-5"},{"key":"2024101100201723000_2024.10.08.24315111v1.44","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3552"},{"issue":"1","key":"2024101100201723000_2024.10.08.24315111v1.45","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1038\/s41467-019-09718-5","article-title":"Polygenic prediction via Bayesian regression and continuous shrinkage priors","volume":"10","year":"2019","journal-title":"Nature Communications"},{"issue":"4","key":"2024101100201723000_2024.10.08.24315111v1.46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: a practical tutorial","volume":"22","year":"2019","journal-title":"Evid Based Ment Health"},{"issue":"10","key":"2024101100201723000_2024.10.08.24315111v1.47","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1111\/add.16290","article-title":"Why do we focus on the exception and not the rule? Examining the prevalence of mono-versus polysubstance use in the general population","volume":"118","year":"2023","journal-title":"Addiction"},{"issue":"10","key":"2024101100201723000_2024.10.08.24315111v1.48","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/s41386-021-01209-w","article-title":"The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates","volume":"47","year":"2022","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"2024101100201723000_2024.10.08.24315111v1.49","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s44220-023-00034-y","article-title":"Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders","volume":"1","year":"2023","journal-title":"Nat Ment Health"},{"key":"2024101100201723000_2024.10.08.24315111v1.50","doi-asserted-by":"crossref","first-page":"108018","DOI":"10.1016\/j.drugalcdep.2020.108018","article-title":"A latent class analysis of heavy substance use in Young adulthood and impacts on physical, cognitive, and mental health outcomes in middle age","volume":"212","year":"2020","journal-title":"Drug Alcohol Depend"},{"issue":"12","key":"2024101100201723000_2024.10.08.24315111v1.51","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/gps.5605","article-title":"The latent class structure of substance use in US adults 50 years and older","volume":"36","year":"2021","journal-title":"Int J Geriatr Psychiatry"},{"key":"2024101100201723000_2024.10.08.24315111v1.52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01630.x"},{"issue":"1","key":"2024101100201723000_2024.10.08.24315111v1.53","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/add.14761","article-title":"The changing patterns and correlates of population-level polysubstance use in Australian youth: a multi-group latent class analysis of nationally representative samples spanning 12 years","volume":"115","year":"2020","journal-title":"Addiction"},{"issue":"2","key":"2024101100201723000_2024.10.08.24315111v1.54","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/dar.13375","article-title":"Polysubstance use classes and health outcomes among women attending specialist substance use treatment services","volume":"41","year":"2022","journal-title":"Drug Alcohol Rev"},{"key":"2024101100201723000_2024.10.08.24315111v1.55","doi-asserted-by":"publisher","DOI":"10.1093\/HMG\/DDAA280"},{"issue":"1","key":"2024101100201723000_2024.10.08.24315111v1.56","doi-asserted-by":"crossref","first-page":"e13282","DOI":"10.1111\/acel.13282","article-title":"SPATA4 improves aging-induced metabolic dysfunction through promotion of preadipocyte differentiation and adipose tissue expansion","volume":"20","year":"2021","journal-title":"Aging Cell"},{"key":"2024101100201723000_2024.10.08.24315111v1.57","doi-asserted-by":"publisher","DOI":"10.1186\/S13072-019-0287-4\/FIGURES\/6"},{"key":"2024101100201723000_2024.10.08.24315111v1.58","doi-asserted-by":"publisher","DOI":"10.1101\/gr.180273.114"},{"issue":"1","key":"2024101100201723000_2024.10.08.24315111v1.59","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13293-021-00381-4","article-title":"A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta","volume":"12","year":"2021","journal-title":"Biol Sex Differ"},{"key":"2024101100201723000_2024.10.08.24315111v1.60","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19791-w"},{"key":"2024101100201723000_2024.10.08.24315111v1.61","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0558-0"},{"issue":"2","key":"2024101100201723000_2024.10.08.24315111v1.62","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3233\/JAD-220293","article-title":"Genome-Wide Association Study of Incident Dementia in a Community-Based Sample of Older Subjects","volume":"88","year":"2022","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"2024101100201723000_2024.10.08.24315111v1.63","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41398-021-01263-4","article-title":"Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer\u2019s disease","volume":"11","author":"Genotype Tissue Expression c","year":"2021","journal-title":"Transl Psychiatry"},{"key":"2024101100201723000_2024.10.08.24315111v1.64","doi-asserted-by":"crossref","first-page":"1179011","DOI":"10.3389\/fnins.2023.1179011","article-title":"Notch signaling as a master regulator of adult neurogenesis","volume":"17","year":"2023","journal-title":"Front Neurosci"},{"issue":"10","key":"2024101100201723000_2024.10.08.24315111v1.65","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1038\/s41380-022-01662-z","article-title":"Medial prefrontal cortex Notch1 signalling mediates methamphetamine-induced psychosis via Hes1-dependent suppression of GABA(B1) receptor expression","volume":"27","year":"2022","journal-title":"Mol Psychiatry"},{"key":"2024101100201723000_2024.10.08.24315111v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.03.017"},{"issue":"1","key":"2024101100201723000_2024.10.08.24315111v1.67","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1038\/s41598-021-82974-y","article-title":"Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex","volume":"11","year":"2021","journal-title":"Sci Rep"},{"issue":"9","key":"2024101100201723000_2024.10.08.24315111v1.68","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.7150\/jca.91955","article-title":"ARID1B Deficiency Leads to Impaired DNA Damage Response and Activated cGAS-STING Pathway in Non-Small Cell Lung Cancer","volume":"15","year":"2024","journal-title":"J Cancer"},{"key":"2024101100201723000_2024.10.08.24315111v1.69","doi-asserted-by":"crossref","unstructured":"Carnes MU , Quach BC , Zhou L , Han S , Tao R , Mandal M et al. Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci. medRxiv 2023.","DOI":"10.1101\/2023.09.18.23295431"},{"key":"2024101100201723000_2024.10.08.24315111v1.70","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08160-w"},{"issue":"5","key":"2024101100201723000_2024.10.08.24315111v1.71","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1089\/omi.2023.0028","article-title":"Gene Set Based Integrated Methylome and Transcriptome Analysis Reveals Potential Molecular Mechanisms Linking Cigarette Smoking and Related Diseases","volume":"27","year":"2023","journal-title":"OMICS"},{"issue":"1","key":"2024101100201723000_2024.10.08.24315111v1.72","first-page":"69","article-title":"Epigenetic control of gene expression in the alcoholic brain","volume":"35","year":"2013","journal-title":"Alcohol Res"},{"key":"2024101100201723000_2024.10.08.24315111v1.73","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12855"},{"issue":"2","key":"2024101100201723000_2024.10.08.24315111v1.74","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/mp.2016.192","article-title":"A DNA methylation biomarker of alcohol consumption","volume":"23","year":"2018","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2024101100201723000_2024.10.08.24315111v1.75","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12915-017-0387-1","article-title":"Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain","volume":"15","year":"2017","journal-title":"BMC Biol"},{"key":"2024101100201723000_2024.10.08.24315111v1.76","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18367-y"},{"key":"2024101100201723000_2024.10.08.24315111v1.77","unstructured":"Grasby KL , Jahanshad N , Painter JN , Colodro-Conde L , Bralten J , Hibar DP et al. The genetic architecture of the human cerebral cortex. Science 2020; 367(6484)."},{"key":"2024101100201723000_2024.10.08.24315111v1.78","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add2870"},{"key":"2024101100201723000_2024.10.08.24315111v1.79","doi-asserted-by":"publisher","DOI":"10.1113\/JP275175"},{"key":"2024101100201723000_2024.10.08.24315111v1.80","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2019-0066"},{"key":"2024101100201723000_2024.10.08.24315111v1.81","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001506"},{"key":"2024101100201723000_2024.10.08.24315111v1.82","doi-asserted-by":"crossref","unstructured":"Kinare V , Pal S , Tole S . LDB1 Is Required for the Early Development of the Dorsal Telencephalon and the Thalamus. eNeuro 2019; 6(1).","DOI":"10.1523\/ENEURO.0356-18.2019"},{"key":"2024101100201723000_2024.10.08.24315111v1.83","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0845-0"},{"issue":"4","key":"2024101100201723000_2024.10.08.24315111v1.84","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.bpsgos.2023.01.007","article-title":"Transcriptional Profile of Exercise-Induced Protection Against Relapse to Cocaine Seeking in a Rat Model","volume":"3","year":"2023","journal-title":"Biol Psychiatry Glob Open Sci"},{"key":"2024101100201723000_2024.10.08.24315111v1.85","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32760"},{"key":"2024101100201723000_2024.10.08.24315111v1.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.12.010"},{"issue":"9-10","key":"2024101100201723000_2024.10.08.24315111v1.87","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1111\/ejn.15223","article-title":"Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction","volume":"55","year":"2022","journal-title":"Eur J Neurosci"},{"key":"2024101100201723000_2024.10.08.24315111v1.88","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2021.102035"},{"key":"2024101100201723000_2024.10.08.24315111v1.89","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26249"},{"key":"2024101100201723000_2024.10.08.24315111v1.90","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.drugalcdep.2015.07.015","article-title":"Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers","volume":"155","year":"2015","journal-title":"Drug Alcohol Depend"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2024.10.08.24315111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:14:18Z","timestamp":1768508058000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2024.10.08.24315111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,8]]},"references-count":90,"URL":"https:\/\/doi.org\/10.1101\/2024.10.08.24315111","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1038\/s41380-025-03031-y","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2024,10,8]]},"subtype":"preprint"}}