{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:28:01Z","timestamp":1783441681952,"version":"3.54.6"},"posted":{"date-parts":[[2024,10,12]]},"group-title":"Neuroscience","reference-count":109,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,3,27]]},"abstract":"<jats:p>Despite the cerebellum\u2019s crucial role in brain functions, its early development, particularly in relation to the cerebrum, remains poorly understood. Here, we examine cerebellocortical connectivity using over 1,000 high-quality resting-state functional MRI scans of children from birth to 60 months. By mapping cerebellar topography with fine temporal detail for the first time, we show the hierarchical organization of cerebellocortical functional connectivity from infancy. We observe dynamic shifts in cerebellar network gradients, which become more focal with age while generally maintaining stable anchor points similar to adults, highlighting the cerebellum\u2019s evolving yet stable role in functional integration during early development. Our findings provide the first evidence of cerebellar connections to higher-order networks at birth, which generally strengthen with age, emphasizing the cerebellum\u2019s early role in cognitive processing beyond sensory and motor functions. Our study provides insights into early cerebellocortical interactions, reveals functional asymmetry and sex-specific patterns in cerebellar development, and lays the groundwork for future research on cerebellum-related disorders in children.<\/jats:p>","DOI":"10.1101\/2024.10.12.617938","type":"posted-content","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T23:55:21Z","timestamp":1728777321000},"source":"Crossref","is-referenced-by-count":1,"title":["The Growing Little Brain: Cerebellar Functional Development from Cradle to School"],"prefix":"10.64898","author":[{"given":"Wenjiao","family":"Lyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim-Han","family":"Thung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoi Minh","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1489-2102","authenticated-orcid":false,"given":"Pew-Thian","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025032911451991000_2024.10.12.617938v2.1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-016-0815-8"},{"key":"2025032911451991000_2024.10.12.617938v2.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.03.011"},{"key":"2025032911451991000_2024.10.12.617938v2.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2009.06.009"},{"key":"2025032911451991000_2024.10.12.617938v2.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.04.021"},{"key":"2025032911451991000_2024.10.12.617938v2.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.08.056"},{"key":"2025032911451991000_2024.10.12.617938v2.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2019.04.023"},{"key":"2025032911451991000_2024.10.12.617938v2.7","first-page":"265","volume-title":"Handbook of Clinical Neurology","volume":"173","year":"2010"},{"key":"2025032911451991000_2024.10.12.617938v2.8","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809338067"},{"key":"2025032911451991000_2024.10.12.617938v2.9","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181e1d032"},{"key":"2025032911451991000_2024.10.12.617938v2.10","doi-asserted-by":"publisher","DOI":"10.1037\/0096-1523.14.4.610"},{"key":"2025032911451991000_2024.10.12.617938v2.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-835X.1997.tb00736.x"},{"key":"2025032911451991000_2024.10.12.617938v2.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2011.01595.x"},{"key":"2025032911451991000_2024.10.12.617938v2.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2010.00981.x"},{"key":"2025032911451991000_2024.10.12.617938v2.14","doi-asserted-by":"publisher","DOI":"10.5432\/ijshs.2.50"},{"key":"2025032911451991000_2024.10.12.617938v2.15","doi-asserted-by":"publisher","DOI":"10.1542\/pir.31-7-267"},{"key":"2025032911451991000_2024.10.12.617938v2.16","doi-asserted-by":"crossref","unstructured":"Tomasello, M. Language development. The Wiley-Blackwell handbook of childhood cognitive development 239\u2013257 (2011). URL https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/9781444325485#page=249.","DOI":"10.1002\/9781444325485.ch9"},{"key":"2025032911451991000_2024.10.12.617938v2.17","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2018.1"},{"key":"2025032911451991000_2024.10.12.617938v2.18","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-65774-4_5"},{"key":"2025032911451991000_2024.10.12.617938v2.19","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp157"},{"key":"2025032911451991000_2024.10.12.617938v2.20","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"2025032911451991000_2024.10.12.617938v2.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.04.011"},{"key":"2025032911451991000_2024.10.12.617938v2.22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1868-09.2009"},{"key":"2025032911451991000_2024.10.12.617938v2.23","doi-asserted-by":"crossref","unstructured":"Guell, X. , Gabrieli, J. D. & Schmahmann, J. D . Triple representation of language, working memory, social and emotion processing in the cerebellum: convergent evidence from task and seed-based resting-state fMRI analyses in a single large cohort. NeuroImage 172 (2018). URL https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105381191830082X.","DOI":"10.1101\/254110"},{"key":"2025032911451991000_2024.10.12.617938v2.24","doi-asserted-by":"publisher","DOI":"10.7554\/elife.36652"},{"key":"2025032911451991000_2024.10.12.617938v2.25","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-019-01083-9"},{"key":"2025032911451991000_2024.10.12.617938v2.26","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00561.2020"},{"key":"2025032911451991000_2024.10.12.617938v2.27","doi-asserted-by":"crossref","unstructured":"Kipping, J. A. , Tuan, T. A. , Fortier, M. V. & Qiu, A . Asynchronous development of cerebellar, cerebello-cortical, and cortico-cortical functional networks in infancy, childhood, and adulthood. Cerebral Cortex 5170\u20135184 (2016). URL http:\/\/cercor.oxfordjournals.org\/cgi\/doi\/10.1093\/cercor\/bhw298.","DOI":"10.1093\/cercor\/bhw298"},{"key":"2025032911451991000_2024.10.12.617938v2.28","doi-asserted-by":"publisher","DOI":"10.1111\/1467-8624.00117"},{"key":"2025032911451991000_2024.10.12.617938v2.29","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21058"},{"key":"2025032911451991000_2024.10.12.617938v2.30","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00100"},{"key":"2025032911451991000_2024.10.12.617938v2.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.01.008"},{"key":"2025032911451991000_2024.10.12.617938v2.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.03.024"},{"key":"2025032911451991000_2024.10.12.617938v2.33","doi-asserted-by":"crossref","unstructured":"Ramos, T. C. , Balardin, J. B. , Sato, J. R. & Fujita, A. Abnormal cortico-cerebellar functional connectivity in autism spectrum disorder. Frontiers in Systems Neuroscience 12 (2019). URL https:\/\/www.frontiersin.org\/articles\/10.3389\/fnsys.2018.00074.","DOI":"10.3389\/fnsys.2018.00074"},{"key":"2025032911451991000_2024.10.12.617938v2.34","doi-asserted-by":"crossref","unstructured":"Adamaszek, M. , Manto, M. & Schutter, D. J. L. G. (eds.) The Emotional Cerebellum, vol. 1378 of Advances in Experimental Medicine and Biology (Springer International Publishing, 2022). URL https:\/\/link.springer.com\/10.1007\/978-3-030-99550-8.","DOI":"10.1007\/978-3-030-99550-8"},{"key":"2025032911451991000_2024.10.12.617938v2.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.03.049"},{"key":"2025032911451991000_2024.10.12.617938v2.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.05.056"},{"key":"2025032911451991000_2024.10.12.617938v2.37","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0459"},{"key":"2025032911451991000_2024.10.12.617938v2.38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133402"},{"key":"2025032911451991000_2024.10.12.617938v2.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.04.012"},{"key":"2025032911451991000_2024.10.12.617938v2.40","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00339.2011"},{"key":"2025032911451991000_2024.10.12.617938v2.41","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0436-x"},{"key":"2025032911451991000_2024.10.12.617938v2.42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210028"},{"key":"2025032911451991000_2024.10.12.617938v2.43","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90463.2008"},{"key":"2025032911451991000_2024.10.12.617938v2.44","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3069-13.2014"},{"key":"2025032911451991000_2024.10.12.617938v2.45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608282113"},{"key":"2025032911451991000_2024.10.12.617938v2.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.07.016"},{"key":"2025032911451991000_2024.10.12.617938v2.47","doi-asserted-by":"crossref","unstructured":"Nettekoven, C. , et al. A hierarchical atlas of the human cerebellum for functional precision mapping. Nature Communications 15 (2024). URL https:\/\/www.nature.com\/articles\/s41467-024-52371-w.","DOI":"10.1038\/s41467-024-52371-w"},{"key":"2025032911451991000_2024.10.12.617938v2.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116960"},{"key":"2025032911451991000_2024.10.12.617938v2.49","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-021-01342-8"},{"key":"2025032911451991000_2024.10.12.617938v2.50","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0262-0"},{"key":"2025032911451991000_2024.10.12.617938v2.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.09.029"},{"key":"2025032911451991000_2024.10.12.617938v2.52","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-008-0031-2"},{"key":"2025032911451991000_2024.10.12.617938v2.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.07.031"},{"key":"2025032911451991000_2024.10.12.617938v2.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.08.016"},{"key":"2025032911451991000_2024.10.12.617938v2.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112281"},{"key":"2025032911451991000_2024.10.12.617938v2.56","doi-asserted-by":"crossref","unstructured":"E, K., Chen, S. A. , Ho, M. R. & Desmond, J. E. A meta-analysis of cerebellar contributions to higher cognition from PET and fMRI studies. Human Brain Mapping 35 (2012). URL https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3866223\/.","DOI":"10.1002\/hbm.22194"},{"key":"2025032911451991000_2024.10.12.617938v2.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.10.01"},{"key":"2025032911451991000_2024.10.12.617938v2.58","doi-asserted-by":"publisher","DOI":"10.1162\/089976698300017124"},{"key":"2025032911451991000_2024.10.12.617938v2.59","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00106.2011"},{"key":"2025032911451991000_2024.10.12.617938v2.60","doi-asserted-by":"publisher","DOI":"10.1159\/000113822"},{"key":"2025032911451991000_2024.10.12.617938v2.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.009"},{"key":"2025032911451991000_2024.10.12.617938v2.62","doi-asserted-by":"crossref","unstructured":"Sasaki, K. Cerebro-cerebellar interactions and organization of a fast and stable hand movement: Cerebellar participation in voluntary movement and motor learning. In Cerebellar Functions, 70\u201385 (Springer, 1985).","DOI":"10.1007\/978-3-642-69980-1_6"},{"key":"2025032911451991000_2024.10.12.617938v2.63","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(94)00168-L"},{"key":"2025032911451991000_2024.10.12.617938v2.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.08.051"},{"key":"2025032911451991000_2024.10.12.617938v2.65","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa398"},{"key":"2025032911451991000_2024.10.12.617938v2.66","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq071"},{"key":"2025032911451991000_2024.10.12.617938v2.67","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1296-8"},{"key":"2025032911451991000_2024.10.12.617938v2.68","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62078-9"},{"key":"2025032911451991000_2024.10.12.617938v2.69","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-014-0597-9"},{"key":"2025032911451991000_2024.10.12.617938v2.70","doi-asserted-by":"crossref","unstructured":"Hortensius, L. M. , et al. Neurodevelopmental consequences of preterm isolated cerebellar hemorrhage: A systematic review. Pediatrics 142 (2018). URL https:\/\/publications.aap.org\/pediatrics\/article\/142\/5\/e20180609\/38536\/Neurodevelopmental-Consequences-of-Preterm.","DOI":"10.1542\/peds.2018-0609"},{"key":"2025032911451991000_2024.10.12.617938v2.71","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-devpsych-121318-084841"},{"key":"2025032911451991000_2024.10.12.617938v2.72","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-55412-y"},{"key":"2025032911451991000_2024.10.12.617938v2.73","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35397-w"},{"key":"2025032911451991000_2024.10.12.617938v2.74","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2021.06.016"},{"key":"2025032911451991000_2024.10.12.617938v2.75","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44087-0"},{"key":"2025032911451991000_2024.10.12.617938v2.76","doi-asserted-by":"crossref","unstructured":"Luo, A. C. , et al. Functional connectivity development along the sensorimotor-association axis enhances the cortical hierarchy. Nature Communications 15 (2024). URL https:\/\/www.nature.com\/articles\/s41467-024-47748-w.","DOI":"10.1038\/s41467-024-47748-w"},{"key":"2025032911451991000_2024.10.12.617938v2.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113770"},{"key":"2025032911451991000_2024.10.12.617938v2.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2017.11.002"},{"key":"2025032911451991000_2024.10.12.617938v2.79","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2022.01.002"},{"key":"2025032911451991000_2024.10.12.617938v2.80","doi-asserted-by":"crossref","unstructured":"Taylor, H. P. , et al. Functional hierarchy of the human neocortex from cradle to grave (2024). URL https:\/\/www.biorxiv.org\/content\/10.1101\/2024.06.14.599109v1.","DOI":"10.1101\/2024.06.14.599109"},{"key":"2025032911451991000_2024.10.12.617938v2.81","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162201001232"},{"key":"2025032911451991000_2024.10.12.617938v2.82","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.775308"},{"key":"2025032911451991000_2024.10.12.617938v2.83","doi-asserted-by":"crossref","unstructured":"Zahn-Waxler, C. , Crick, N. R. , Shirtcliff, E. A. & Woods, K. E. The origins and development of psychopathology in females and males. In Developmental Psychopathology, 76\u2013138 (John Wiley & Sons, Ltd, 2015). URL https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/9780470939383.ch4.","DOI":"10.1002\/9780470939383.ch4"},{"key":"2025032911451991000_2024.10.12.617938v2.84","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22850"},{"key":"2025032911451991000_2024.10.12.617938v2.85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2009.00933.x"},{"key":"2025032911451991000_2024.10.12.617938v2.86","doi-asserted-by":"publisher","DOI":"10.1080\/01650250143000463"},{"key":"2025032911451991000_2024.10.12.617938v2.87","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02222-9"},{"key":"2025032911451991000_2024.10.12.617938v2.88","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.07.004"},{"key":"2025032911451991000_2024.10.12.617938v2.89","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(02)91132-8"},{"key":"2025032911451991000_2024.10.12.617938v2.90","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00336-7"},{"key":"2025032911451991000_2024.10.12.617938v2.91","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"2025032911451991000_2024.10.12.617938v2.92","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.06.060"},{"key":"2025032911451991000_2024.10.12.617938v2.93","doi-asserted-by":"publisher","DOI":"10.1038\/nature18933"},{"key":"2025032911451991000_2024.10.12.617938v2.94","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.064"},{"key":"2025032911451991000_2024.10.12.617938v2.95","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.12.073"},{"key":"2025032911451991000_2024.10.12.617938v2.96","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(09)70884-5"},{"key":"2025032911451991000_2024.10.12.617938v2.97","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.033"},{"key":"2025032911451991000_2024.10.12.617938v2.98","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-01008-z"},{"key":"2025032911451991000_2024.10.12.617938v2.99","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.127"},{"key":"2025032911451991000_2024.10.12.617938v2.100","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"2025032911451991000_2024.10.12.617938v2.101","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"2025032911451991000_2024.10.12.617938v2.102","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(09)71514-9"},{"key":"2025032911451991000_2024.10.12.617938v2.103","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"2025032911451991000_2024.10.12.617938v2.104","first-page":"463704","article-title":"Intrinsic frequencies of the resting-state fMRI signal: the frequency dependence of functional connectivity and the effect of mode mixing","volume":"13","year":"2019","journal-title":"Frontiers in Neuroscience"},{"key":"2025032911451991000_2024.10.12.617938v2.105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/cem.1122","article-title":"Resolving the sign ambiguity in the singular value decomposition","volume":"22","year":"2008","journal-title":"Journal of Chemometrics: A Journal of the Chemometrics Society"},{"key":"2025032911451991000_2024.10.12.617938v2.106","unstructured":"Wood, S. & Scheipl, F . gamm4: Generalized additive mixed models using \u2018mgcv\u2019 and \u2018lme4\u2019 (2017). URL https:\/\/CRAN.R-project.org\/package=gamm4. R package version 0.2-6."},{"key":"2025032911451991000_2024.10.12.617938v2.107","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.09.078"},{"key":"2025032911451991000_2024.10.12.617938v2.108","unstructured":"Mullen, E. M. et al. Mullen scales of early learning (AGS Circle Pines, MN, 1995)."},{"key":"2025032911451991000_2024.10.12.617938v2.109","doi-asserted-by":"crossref","unstructured":"Wickham, H. ggplot2: Elegant Graphics for Data Analysis (Springer-Verlag New York, 2016). URL https:\/\/ggplot2.tidyverse.org.","DOI":"10.1007\/978-3-319-24277-4_9"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2024.10.12.617938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:14:44Z","timestamp":1768461284000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2024.10.12.617938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,12]]},"references-count":109,"URL":"https:\/\/doi.org\/10.1101\/2024.10.12.617938","relation":{},"subject":[],"published":{"date-parts":[[2024,10,12]]},"subtype":"preprint"}}