{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:23:47Z","timestamp":1785198227501,"version":"3.55.0"},"posted":{"date-parts":[[2024,10,14]]},"group-title":"Epidemiology","reference-count":49,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>\n                    History of\n                    <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                    infection has previously been associated with epithelial ovarian cancer (EOC) in observational studies. We conducted a two-sample univariable Mendelian randomisation (MR) study to examine whether genetically predicted seropositivity to the\n                    <jats:italic>C. trachomatis<\/jats:italic>\n                    major outer membrane protein (momp) D is causally associated with EOC.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>MR analyses employed genetic associations derived from UK Biobank as proxies for momp D seropositivity in 25 509 EOC cases and 40 941 controls that participated in the Ovarian Cancer Association Consortium. Findings were replicated using a GWAS meta-analyses of global biobanks including the UK Biobank, FinnGen and BioBank Japan.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Genetically predicted momp D seropositivity was associated with overall and high-grade serous EOC risk in inverse-variance weighted (IVW) and MR-Egger univariable MR analysis (odds ratio (OR) 1.06; 95% confidence interval (CI) 1.02\u20141.10, and OR 1.08; 95%CI 1.01\u20141.16, respectively). Replication yielded similar results for overall EOC (OR 1.11; 95%CI 1.01\u20141.22).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>\n                    This MR study supports a causative link between\n                    <jats:italic>C. trachomatis<\/jats:italic>\n                    infection and overall and high-grade serous EOC.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2024.10.13.24315417","type":"posted-content","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T13:15:16Z","timestamp":1728911716000},"source":"Crossref","is-referenced-by-count":2,"title":["Appraisal of the causal effect of\n                  <i>Chlamydia trachomatis<\/i>\n                  infection on epithelial ovarian cancer risk: a two-sample Mendelian randomisation study"],"prefix":"10.64898","author":[{"given":"Sarah L.","family":"Perrott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2314-1426","authenticated-orcid":false,"given":"Siddhartha P.","family":"Kar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024101607500493000_2024.10.13.24315417v1.1","unstructured":"1. 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Global, regional, and national burden of ovarian cancer and the attributable risk factors in all 194 countries and territories during 2007-2017: A systematic analysis of the Global Burden of Disease Study 2017 (2021).","DOI":"10.1111\/jog.15019"},{"key":"2024101607500493000_2024.10.13.24315417v1.7","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.tranon.2018.02.008","article-title":"Chlamydia trachomatis, Chlamydial Heat Shock Protein 60 and Anti-Chlamydial Antibodies in Women with Epithelial Ovarian Tumors Translational Oncology","volume":"11","year":"2018","journal-title":"Transl Oncol"},{"key":"2024101607500493000_2024.10.13.24315417v1.8","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e328348a6e7"},{"key":"2024101607500493000_2024.10.13.24315417v1.9","doi-asserted-by":"crossref","unstructured":"Kyo, S. , Ishikawa, N. , Nakamura, K. & Nakayama, K . The fallopian tube as origin of ovarian cancer: Change of diagnostic and preventive strategies. 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