{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:05:41Z","timestamp":1789088741853,"version":"build-2803163510"},"posted":{"date-parts":[[2024,10,22]]},"group-title":"Microbiology","reference-count":188,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,10,29]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>\n                  <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                  is the most common cause of fungal meningitis and the top-ranked W.H.O. priority fungal pathogen. Only distantly related to model fungi,\n                  <jats:italic>C. neoformans<\/jats:italic>\n                  is also a powerful experimental system for exploring conserved eukaryotic mechanisms lost from specialist model yeast lineages. To decipher its biology globally, we constructed 4328 gene deletions and measured\u2014with exceptional precision--the fitness of each mutant under 141 diverse growth-limiting\n                  <jats:italic>in vitro<\/jats:italic>\n                  conditions and during murine infection. We defined functional modules by clustering genes based on their phenotypic signatures. In-depth studies leveraged these data in two ways. First, we defined and investigated new components of key signaling pathways, which revealed animal-like pathways\/components not predicted from studies of model yeasts. Second, we identified environmental adaptation mechanisms repurposed to promote mammalian virulence by\n                  <jats:italic>C. neoformans<\/jats:italic>\n                  , which lacks a known animal reservoir. Our work provides an unprecedented resource for deciphering a deadly human pathogen.\n                <\/jats:p>","DOI":"10.1101\/2024.10.22.619677","type":"posted-content","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T23:20:15Z","timestamp":1729639215000},"source":"Crossref","is-referenced-by-count":12,"title":["Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology"],"prefix":"10.64898","author":[{"given":"Michael J.","family":"Boucher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjita","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi B.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manning Y.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Ciranni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Condon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Langen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Goddard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ippolito","family":"Caradonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexi I.","family":"Goranov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Homer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassaman","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Petnic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgann C.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Susa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito Paolo","family":"Pastore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balyn W.","family":"Zaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7400-6657","authenticated-orcid":false,"given":"Hiten D.","family":"Madhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024110206550499000_2024.10.22.619677v2.1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(22)00499-6"},{"key":"2024110206550499000_2024.10.22.619677v2.2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(23)00692-8"},{"key":"2024110206550499000_2024.10.22.619677v2.3","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"2024110206550499000_2024.10.22.619677v2.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00861-x"},{"key":"2024110206550499000_2024.10.22.619677v2.5","unstructured":"WHO\/UCN\/HHS\/SIA\/2023.05 (2024). South Africa HIV Country Profile 2023."},{"key":"2024110206550499000_2024.10.22.619677v2.6","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002095"},{"key":"2024110206550499000_2024.10.22.619677v2.7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.60.080805.142102"},{"key":"2024110206550499000_2024.10.22.619677v2.8","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2015.6"},{"key":"2024110206550499000_2024.10.22.619677v2.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.167"},{"key":"2024110206550499000_2024.10.22.619677v2.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2023.10.011"},{"key":"2024110206550499000_2024.10.22.619677v2.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbr.2010.03.001"},{"key":"2024110206550499000_2024.10.22.619677v2.12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1003"},{"key":"2024110206550499000_2024.10.22.619677v2.13","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyae035"},{"key":"2024110206550499000_2024.10.22.619677v2.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.12.012"},{"key":"2024110206550499000_2024.10.22.619677v2.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.039"},{"key":"2024110206550499000_2024.10.22.619677v2.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.01.046"},{"key":"2024110206550499000_2024.10.22.619677v2.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-023-01000-z"},{"key":"2024110206550499000_2024.10.22.619677v2.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.09.004"},{"key":"2024110206550499000_2024.10.22.619677v2.19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091317"},{"key":"2024110206550499000_2024.10.22.619677v2.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.031"},{"key":"2024110206550499000_2024.10.22.619677v2.21","doi-asserted-by":"publisher","DOI":"10.1038\/nature05649"},{"key":"2024110206550499000_2024.10.22.619677v2.22","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth1098"},{"key":"2024110206550499000_2024.10.22.619677v2.23","doi-asserted-by":"publisher","DOI":"10.4161\/cib.7501"},{"key":"2024110206550499000_2024.10.22.619677v2.24","doi-asserted-by":"publisher","DOI":"10.1126\/science.1180823"},{"key":"2024110206550499000_2024.10.22.619677v2.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.028"},{"key":"2024110206550499000_2024.10.22.619677v2.26","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0370-6"},{"key":"2024110206550499000_2024.10.22.619677v2.27","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01052-9"},{"key":"2024110206550499000_2024.10.22.619677v2.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.11.007"},{"key":"2024110206550499000_2024.10.22.619677v2.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.06.008"},{"key":"2024110206550499000_2024.10.22.619677v2.30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49844-3"},{"key":"2024110206550499000_2024.10.22.619677v2.31","doi-asserted-by":"publisher","DOI":"10.1038\/ng.605"},{"key":"2024110206550499000_2024.10.22.619677v2.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.046"},{"key":"2024110206550499000_2024.10.22.619677v2.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.044"},{"key":"2024110206550499000_2024.10.22.619677v2.34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18028-0"},{"key":"2024110206550499000_2024.10.22.619677v2.35","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7757"},{"key":"2024110206550499000_2024.10.22.619677v2.36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15329-2"},{"key":"2024110206550499000_2024.10.22.619677v2.37","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12766"},{"key":"2024110206550499000_2024.10.22.619677v2.38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.25.12008"},{"key":"2024110206550499000_2024.10.22.619677v2.39","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.9.4831-4841.2003"},{"key":"2024110206550499000_2024.10.22.619677v2.40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000283"},{"key":"2024110206550499000_2024.10.22.619677v2.41","doi-asserted-by":"publisher","DOI":"10.1101\/2024.07.28.605507"},{"key":"2024110206550499000_2024.10.22.619677v2.42","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2223-2227.2004"},{"key":"2024110206550499000_2024.10.22.619677v2.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13890-z"},{"key":"2024110206550499000_2024.10.22.619677v2.44","doi-asserted-by":"publisher","DOI":"10.3109\/10408418709104447"},{"key":"2024110206550499000_2024.10.22.619677v2.45","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.6.4101"},{"key":"2024110206550499000_2024.10.22.619677v2.46","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00189-08"},{"key":"2024110206550499000_2024.10.22.619677v2.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2008.10.003"},{"key":"2024110206550499000_2024.10.22.619677v2.48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001209"},{"key":"2024110206550499000_2024.10.22.619677v2.49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05676.x"},{"key":"2024110206550499000_2024.10.22.619677v2.50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030022"},{"key":"2024110206550499000_2024.10.22.619677v2.51","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.19.7044-7054.2003"},{"key":"2024110206550499000_2024.10.22.619677v2.52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06895.x"},{"key":"2024110206550499000_2024.10.22.619677v2.53","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00207-09"},{"key":"2024110206550499000_2024.10.22.619677v2.54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002374"},{"key":"2024110206550499000_2024.10.22.619677v2.55","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.23.3206"},{"key":"2024110206550499000_2024.10.22.619677v2.56","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.9.3179-3191.2001"},{"key":"2024110206550499000_2024.10.22.619677v2.57","doi-asserted-by":"publisher","DOI":"10.1128\/EC.1.1.75-84.2002"},{"key":"2024110206550499000_2024.10.22.619677v2.58","doi-asserted-by":"publisher","DOI":"10.1128\/EC.3.6.1476-1491.2004"},{"key":"2024110206550499000_2024.10.22.619677v2.59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602768200"},{"key":"2024110206550499000_2024.10.22.619677v2.60","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00109-14"},{"key":"2024110206550499000_2024.10.22.619677v2.61","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00398-06"},{"key":"2024110206550499000_2024.10.22.619677v2.62","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00290-13"},{"key":"2024110206550499000_2024.10.22.619677v2.63","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.046"},{"key":"2024110206550499000_2024.10.22.619677v2.64","doi-asserted-by":"publisher","DOI":"10.1007\/s40588-023-00195-5"},{"key":"2024110206550499000_2024.10.22.619677v2.65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005159"},{"key":"2024110206550499000_2024.10.22.619677v2.66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005159"},{"key":"2024110206550499000_2024.10.22.619677v2.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2008.03.006"},{"key":"2024110206550499000_2024.10.22.619677v2.68","doi-asserted-by":"publisher","DOI":"10.1007\/s40588-023-00195-5"},{"key":"2024110206550499000_2024.10.22.619677v2.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2014.09.005"},{"key":"2024110206550499000_2024.10.22.619677v2.70","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvn030"},{"key":"2024110206550499000_2024.10.22.619677v2.71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07822.x"},{"key":"2024110206550499000_2024.10.22.619677v2.72","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.84515"},{"key":"2024110206550499000_2024.10.22.619677v2.73","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80292-5"},{"key":"2024110206550499000_2024.10.22.619677v2.74","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-9525(03)00052-0"},{"key":"2024110206550499000_2024.10.22.619677v2.75","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81960-1"},{"key":"2024110206550499000_2024.10.22.619677v2.76","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyab180"},{"key":"2024110206550499000_2024.10.22.619677v2.77","doi-asserted-by":"publisher","DOI":"10.1101\/2021.10.04.463034"},{"key":"2024110206550499000_2024.10.22.619677v2.78","doi-asserted-by":"publisher","DOI":"10.1002\/pro.19"},{"key":"2024110206550499000_2024.10.22.619677v2.79","doi-asserted-by":"publisher","DOI":"10.1021\/ja108943n"},{"key":"2024110206550499000_2024.10.22.619677v2.80","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b10984"},{"key":"2024110206550499000_2024.10.22.619677v2.81","doi-asserted-by":"publisher","DOI":"10.1101\/2024.04.17.590000"},{"key":"2024110206550499000_2024.10.22.619677v2.82","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00014.2022"},{"key":"2024110206550499000_2024.10.22.619677v2.83","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mss182"},{"key":"2024110206550499000_2024.10.22.619677v2.84","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00015"},{"key":"2024110206550499000_2024.10.22.619677v2.85","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.10.2343"},{"key":"2024110206550499000_2024.10.22.619677v2.86","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205037200"},{"key":"2024110206550499000_2024.10.22.619677v2.87","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.03246.x"},{"key":"2024110206550499000_2024.10.22.619677v2.88","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.09.058"},{"key":"2024110206550499000_2024.10.22.619677v2.89","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-010-0673-6"},{"key":"2024110206550499000_2024.10.22.619677v2.90","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(93)90069-Y"},{"key":"2024110206550499000_2024.10.22.619677v2.91","doi-asserted-by":"publisher","DOI":"10.1007\/BF02737887"},{"key":"2024110206550499000_2024.10.22.619677v2.92","doi-asserted-by":"publisher","DOI":"10.1038\/352803a0"},{"key":"2024110206550499000_2024.10.22.619677v2.93","doi-asserted-by":"publisher","DOI":"10.1038\/357695a0"},{"key":"2024110206550499000_2024.10.22.619677v2.94","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-0987-9_17"},{"key":"2024110206550499000_2024.10.22.619677v2.95","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000703"},{"key":"2024110206550499000_2024.10.22.619677v2.96","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.24.3445"},{"key":"2024110206550499000_2024.10.22.619677v2.97","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.24.3432"},{"key":"2024110206550499000_2024.10.22.619677v2.98","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051403"},{"key":"2024110206550499000_2024.10.22.619677v2.99","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2013.024"},{"key":"2024110206550499000_2024.10.22.619677v2.100","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005873"},{"key":"2024110206550499000_2024.10.22.619677v2.101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006667"},{"key":"2024110206550499000_2024.10.22.619677v2.102","doi-asserted-by":"publisher","DOI":"10.3390\/jof9020252"},{"key":"2024110206550499000_2024.10.22.619677v2.103","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00158-06"},{"key":"2024110206550499000_2024.10.22.619677v2.104","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.10.2576"},{"key":"2024110206550499000_2024.10.22.619677v2.105","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/159.4.1527"},{"key":"2024110206550499000_2024.10.22.619677v2.106","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01773-0"},{"key":"2024110206550499000_2024.10.22.619677v2.107","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01049-22"},{"key":"2024110206550499000_2024.10.22.619677v2.108","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231573"},{"key":"2024110206550499000_2024.10.22.619677v2.109","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3251"},{"key":"2024110206550499000_2024.10.22.619677v2.110","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0140-1"},{"key":"2024110206550499000_2024.10.22.619677v2.111","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0362-1"},{"key":"2024110206550499000_2024.10.22.619677v2.112","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0324-7"},{"key":"2024110206550499000_2024.10.22.619677v2.113","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0340-7"},{"key":"2024110206550499000_2024.10.22.619677v2.114","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-024-01381-9"},{"key":"2024110206550499000_2024.10.22.619677v2.115","doi-asserted-by":"publisher","DOI":"10.1126\/science.3291120"},{"key":"2024110206550499000_2024.10.22.619677v2.116","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.5.1882"},{"key":"2024110206550499000_2024.10.22.619677v2.117","doi-asserted-by":"publisher","DOI":"10.1007\/BF00266239"},{"key":"2024110206550499000_2024.10.22.619677v2.118","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.10.043"},{"key":"2024110206550499000_2024.10.22.619677v2.119","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2006.02.007"},{"key":"2024110206550499000_2024.10.22.619677v2.120","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15879-5"},{"key":"2024110206550499000_2024.10.22.619677v2.121","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2021.04.002"},{"key":"2024110206550499000_2024.10.22.619677v2.122","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2022.102198"},{"key":"2024110206550499000_2024.10.22.619677v2.123","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.012"},{"key":"2024110206550499000_2024.10.22.619677v2.124","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000200"},{"key":"2024110206550499000_2024.10.22.619677v2.125","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00089-06"},{"key":"2024110206550499000_2024.10.22.619677v2.126","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00120-07"},{"key":"2024110206550499000_2024.10.22.619677v2.127","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-63"},{"key":"2024110206550499000_2024.10.22.619677v2.128","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E13-12-0729"},{"key":"2024110206550499000_2024.10.22.619677v2.129","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.09.003"},{"key":"2024110206550499000_2024.10.22.619677v2.130","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.01.007"},{"key":"2024110206550499000_2024.10.22.619677v2.131","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.52337"},{"key":"2024110206550499000_2024.10.22.619677v2.132","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00089-06"},{"key":"2024110206550499000_2024.10.22.619677v2.133","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00120-07"},{"key":"2024110206550499000_2024.10.22.619677v2.134","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01087-13"},{"key":"2024110206550499000_2024.10.22.619677v2.135","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02313-21"},{"key":"2024110206550499000_2024.10.22.619677v2.136","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.02.003"},{"key":"2024110206550499000_2024.10.22.619677v2.137","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.001"},{"key":"2024110206550499000_2024.10.22.619677v2.138","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12480"},{"key":"2024110206550499000_2024.10.22.619677v2.139","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040695"},{"key":"2024110206550499000_2024.10.22.619677v2.140","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.00644-21"},{"key":"2024110206550499000_2024.10.22.619677v2.141","doi-asserted-by":"publisher","DOI":"10.3389\/ffunb.2021.821946"},{"key":"2024110206550499000_2024.10.22.619677v2.142","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03780.x"},{"key":"2024110206550499000_2024.10.22.619677v2.143","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05551.x"},{"key":"2024110206550499000_2024.10.22.619677v2.144","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2319707121"},{"key":"2024110206550499000_2024.10.22.619677v2.145","doi-asserted-by":"publisher","DOI":"10.3389\/ffunb.2022.1061841"},{"key":"2024110206550499000_2024.10.22.619677v2.146","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03780.x"},{"key":"2024110206550499000_2024.10.22.619677v2.147","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2023.10.011"},{"key":"2024110206550499000_2024.10.22.619677v2.148","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2006.00198.x"},{"key":"2024110206550499000_2024.10.22.619677v2.149","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01649-14"},{"key":"2024110206550499000_2024.10.22.619677v2.150","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-015-0532-3"},{"key":"2024110206550499000_2024.10.22.619677v2.151","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006051"},{"key":"2024110206550499000_2024.10.22.619677v2.152","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20220124"},{"key":"2024110206550499000_2024.10.22.619677v2.153","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2014.05.011"},{"key":"2024110206550499000_2024.10.22.619677v2.154","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01537-17"},{"key":"2024110206550499000_2024.10.22.619677v2.155","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21965-y"},{"key":"2024110206550499000_2024.10.22.619677v2.156","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02135-18"},{"key":"2024110206550499000_2024.10.22.619677v2.157","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000815"},{"key":"2024110206550499000_2024.10.22.619677v2.158","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.119.302290"},{"key":"2024110206550499000_2024.10.22.619677v2.159","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02682-19"},{"key":"2024110206550499000_2024.10.22.619677v2.160","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00719-20"},{"key":"2024110206550499000_2024.10.22.619677v2.161","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01920-20"},{"key":"2024110206550499000_2024.10.22.619677v2.162","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00761-20"},{"key":"2024110206550499000_2024.10.22.619677v2.163","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msaa324"},{"key":"2024110206550499000_2024.10.22.619677v2.164","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008871"},{"key":"2024110206550499000_2024.10.22.619677v2.165","doi-asserted-by":"publisher","DOI":"10.3389\/ffunb.2021.640678"},{"key":"2024110206550499000_2024.10.22.619677v2.166","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.08.017"},{"key":"2024110206550499000_2024.10.22.619677v2.167","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00134-22"},{"key":"2024110206550499000_2024.10.22.619677v2.168","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01904-23"},{"key":"2024110206550499000_2024.10.22.619677v2.169","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00196-23"},{"key":"2024110206550499000_2024.10.22.619677v2.170","doi-asserted-by":"publisher","DOI":"10.3390\/jof9060672"},{"key":"2024110206550499000_2024.10.22.619677v2.171","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03078-23"},{"key":"2024110206550499000_2024.10.22.619677v2.172","doi-asserted-by":"publisher","DOI":"10.1038\/nature00935"},{"key":"2024110206550499000_2024.10.22.619677v2.173","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1628"},{"key":"2024110206550499000_2024.10.22.619677v2.174","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-040-9_13"},{"key":"2024110206550499000_2024.10.22.619677v2.175","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1832"},{"key":"2024110206550499000_2024.10.22.619677v2.176","doi-asserted-by":"publisher","DOI":"10.1534\/g3.117.300357"},{"key":"2024110206550499000_2024.10.22.619677v2.177","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(10)70033-1"},{"key":"2024110206550499000_2024.10.22.619677v2.178","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"2024110206550499000_2024.10.22.619677v2.179","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"2024110206550499000_2024.10.22.619677v2.180","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0843-6"},{"key":"2024110206550499000_2024.10.22.619677v2.181","doi-asserted-by":"publisher","DOI":"10.1101\/gr.209601.116"},{"key":"2024110206550499000_2024.10.22.619677v2.182","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"2024110206550499000_2024.10.22.619677v2.183","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxw041"},{"key":"2024110206550499000_2024.10.22.619677v2.184","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth078"},{"key":"2024110206550499000_2024.10.22.619677v2.185","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth349"},{"key":"2024110206550499000_2024.10.22.619677v2.186","doi-asserted-by":"publisher","DOI":"10.3390\/jof4010039"},{"key":"2024110206550499000_2024.10.22.619677v2.187","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"2024110206550499000_2024.10.22.619677v2.188","doi-asserted-by":"publisher","DOI":"10.1002\/cpmc.94"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2024.10.22.619677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:18:58Z","timestamp":1768461538000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2024.10.22.619677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":188,"URL":"https:\/\/doi.org\/10.1101\/2024.10.22.619677","relation":{},"subject":[],"published":{"date-parts":[[2024,10,22]]},"subtype":"preprint"}}