{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:18:19Z","timestamp":1768519099959,"version":"3.49.0"},"posted":{"date-parts":[[2024,10,29]]},"group-title":"Microbiology","reference-count":99,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,10,29]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>\n                  <jats:italic>Candida albicans<\/jats:italic>\n                  is a leading cause of life-threatening invasive infections with up to 40% mortality rates in hospitalized individuals despite antifungal therapy. Patients with chronic liver disease are at an increased risk of candidemia, but the mechanisms underlying this susceptibility are incompletely defined. One consequence of chronic liver disease is attenuated ability to produce hepcidin and maintain organismal control of iron homeostasis. To address the biology underlying this critical clinical problem, we demonstrate the mechanistic link between hepcidin insufficiency and candida infection using genetic and inducible hepcidin knockout mice. Hepcidin deficiency led to unrestrained fungal growth and increased transition to the invasive hypha morphology with exposed 1,3, \u03b2-glucan that exacerbated kidney injury, independent of the fungal pore-forming toxin candidalysin in immunocompetent mice. Of translational relevance, the therapeutic administration of PR-73, a hepcidin mimetic, improved the outcomes of infection. Thus, we identify hepcidin deficiency as a novel host susceptibility factor against\n                  <jats:italic>C. albicans<\/jats:italic>\n                  and hepcidin mimetics as a potential intervention.\n                <\/jats:p>","DOI":"10.1101\/2024.10.29.620511","type":"posted-content","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T23:06:30Z","timestamp":1730243190000},"source":"Crossref","is-referenced-by-count":3,"title":["Essential role of Hepcidin in host resistance to disseminated 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